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PD Dr. med. A. Hoetzel
Schriftenverzeichnis, PD Dr. Alexander Hötzel zurück >
Originalarbeiten
Hoetzel A, Schmidt R, Vallbracht S, Goebel U, Dolinay T, Kim HP, Ifedigbo E, Ryter SW, Choi AMK, Carbon monoxide prevents ventilator induced lung injury via caveolin-1 Care Med 2009; 37:1708-15., Schmidt R, Vallbracht S, Goebel U, Dolinay T, Kim HP, Ifedigbo E, Ryter -1. Crit Care Med 2009; 37:1708-15.
Schwer CI, Guerrero AM, Humar M, Roesslein M, Goebel U, Stoll P, Geiger KK, Pannen BH, Hoetzel A, Schmidt R. Heme oxygenase-1 inhibits the proliferation of pancreatic stellate cells by repression of the ERK1/2 pathway. J Pharmacol Exp Ther 2008; 327:863-71
Hoetzel A, Dolinay T, Vallbracht S, Zhang Y, Kim HP, Ifedigbo E, Alber S, Kaynar AM, Schmidt R, Ryter SW, Choi AMK. Carbon monoxide protects against ventilator-induced lung injury via PPAR-and inhibition of Egr-1. Am J Resp Crit Care Med 2008; 177:1223-32.
Dolinay T, Wu W, Kaminski N, Ifedigbo E, Kaynar AM, Szilasi M, Watkins SC, Ryter SW, Hoetzel A, Choi AM. Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. PloS ONE 2008; 13:e1601.
Hoetzel A, Welle A, Schmidt R, Loop T, Humar M, Ryter SW, Geiger KK, Choi AM, Pannen BHJ. Nitric oxide-Deficiency Regulates Hepatic Heme Oxygenase–1. Nitric oxide 2008; 18:61-9.
Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Heimrich B, Roesslein M, Schmidt R, Schwer C, Hoetzel A, Loop T, Pahl HL, Geiger KK, Pannen BH. Repression of T-cell function by thionamides is mediated by inhibition of the AP-1/NFAT pathway and is associated with a common structure. Mol Pharmacol 2007; 72:1647-54.
Humar M, Loop T, Schmidt R, Hoetzel A, Roesslein M, Andriopoulos N, Pahl HL, Geiger KK, Pannen BHJ. The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun. Int J Biochem Cell Biol 2007. 39:2278-88.
Schmidt R, Tritschler E, Hoetzel A, Loop T, Humar M, Halverscheid L, Geiger KK, Pannen BHJ.Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury. Ann Surg 2007. 245:931-42.
Schmidt R, Baechle T, Hoetzel A, Loop T, Humar M, Roesslein M, Geiger KK, Pannen BH. Dihydralazine treatment limits liver injury after hemorrhagic shock in rats. Crit Care Med 2006 34:815-22.
Hoetzel A, Leitz D, Schmidt R, Tritschler E, Bauer I, Loop T, Humar M, Geiger KK, Pannen BH. Mechanism of hepatic heme oxygenase-1 induction by isoflurane. Anesthesiology 2006. 104:101-9.
Loop T, Dovi-Akue D, Frick M, Roesslein M, Egger L, Humar M, Hoetzel A, Schmidt R, Borner C, Pahl HL, Geiger KK, Pannen BH. Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro. Anesthesiology 2005. 102:1147-57.
Schmidt R, Hoetzel A, Baechle T, Loop T, Humar M, Bauer M, Pahl HL, Geiger KK, Pannen BHJ. Isoflurane pretreatment lowers portal venous resistance by increasing hepatic heme oxygenase activity in the rat liver in vivo. J Hepatol 2004. 4:706-13.
Loop T, Bross T, Humar M, Hoetzel A, Schmidt R, Pahl HL, Geiger KK, Pannen BHJ. Dobutamine inhibits phorbol-myristate-acetate (PMA)-induced activation of nuclear factor-kappaB in human T-lymphocytes in vitro. Anesth Analg 2004. 99:1508-15.
Humar M, Andriopoulos N, Pischke SE, Loop T, Schmidt R, Hoetzel A, Roesslein M, Pahl HL, Geiger KK, Pannen BHJ. Inhibition of AP-1 by barbiturates is mediated by differential effects on MAP-kinases and the small G proteins Ras and Rac-1. J Pharmacol Exp Ther 2004. 311:1232-40.
Loop T, Scheiermann P, Doviakue D, Musshoff F, Humar M, Roesslein M, Hoetzel A, Schmidt R, Madea B, Geiger KK, Pahl HL, Pannen BHJ. Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro: potential role of the p38-stress kinase pathway. Anesthesiology 2004. 101:710-21.
Humar M, Pischke SE, Loop T, Hoetzel A, Schmidt R, Klaas C, Pahl HL, Geiger KK, Pannen BHJ. Barbiturates directly inhibit the calmodulin/calcineurin complex: a novel mechanism of inhibition of nuclear factor of activated T cells. Mol Pharmacol 2004; 65:350-61.
Loop T; Humar M, Pischke S, Hoetzel A, Schmidt R, Pahl HL, Geiger KK, Pannen BHJ. Thiopental inhibits tumor necrosis factor -induced activation of nuclear factor B through suppression of IB kinase activity. Anesthesiology 2003; 99:360-7.
Hoetzel A, Geiger S, Loop T, Welle A, Schmidt R, Humar M, Pahl HL, Geiger KK, Pannen BHJ. Differential effects of volatile anesthetics on hepatic heme oxygenase-1 expression in the rat. Anesthesiology 2002; 97: 1318-21.
Loop T, Liu Z, Humar M, Hoetzel A, Benzing A, Pahl HL, Geiger KK, Pannen BHJ. Thiopental inhibits the activation of nuclear factor-kappaB. Anesthesiology 2001; 96: 1202-13.
Pannen BHJ, Schroll S, Loop T, Bauer M, Hoetzel A, Geiger KK. Hemorrhagic shock primes the hepatic portal circulation for the vasoconstrictive effects of endothelin-1. Am J Physiol Heart Circ Physiol. 2001; 281:H1075-84.
Hoetzel A, Vagts DA, Loop T, Humar M, Bauer M, Pahl HL, Geiger KK, Pannen BHJ. Effect of nitric oxide on shock-induced hepatic heme oxygenase-1 expression in the rat. Hepatology 2001; 33:925-37.
Masterman D, DeSalles A, Baloh RW, Frysinger R, Foti D, Behnke E, Cabatan Awang C, Hoetzel A, Intemann PM, Fairbanks L., Bronstein JM. Motor, cognitive, and behavioral performance following unilateral ventroposterior pallidotomy for Parkinson disease. Arch Neurol 1998; 55:1201-08.
Übersichtsarbeiten
Hoetzel A, Dolinay T, Schmidt R, Choi AMK, Ryter SW. Carbon monoxide in sepsis. Antioxid Redox Signal 2007; 9:2013-26
Ryter SW, Kim HP, Hoetzel A, Park JW, Nakahira K, Wang X, Choi AM. Mechanisms of cell death in oxidative stress. Antioxid Redox Signal 2007. 9: 49-89.
Hoetzel A, Schmidt R. Carbon monoxide - poison or potential therapeutic? [German]. Anaesthesist 2006. 55: 1068-79.
Hoetzel A and Geiger K. Stress proteins: basics and implications for anaesthesia & intensive care medicine [German]. Anästhesiologie & Intensivmedizin 2003. 44: 145-158.
Kasuistiken
Szibor-Kriesen U, Devide A, Hoetzel A, Vagts DA. Unstillbarer Schluckauf beim Patienten in der perioperativen Phase. Anasthesiol Intensivmed Notfallmed Schmerzther 2008; 43:674-676.
Buchbeiträge
Hoetzel A, Vasoaktive Medikamente, In: Benzing A, Pannen BHJ (Hrsg.): Praxishandbuch Anästhesie Spitta Verlag 2006.
Wissenschaftliche Vorträge und Abstrakts
American Thoracic Society, annual meeting 2009, San Diego, USA: “Suspended animation inducer hydrogen sulfide prevents ventilator associated lung injury”.
Antrittsvorlesung, Universität Freiburg 2009: “Kohlenmonoxid: Gift oder potenzielles Therapeutikum”.
Medizinische Fakultät der Universität Freiburg 2009: “Das therapeutische Potenzial der suspended animation”.
American Thoracic Society, annual meeting 2008, Toronto, Canada: “Carbon monoxide prevents ventilator induced lung injury via caveolin-1“.
The 5th International Congress on Heme Oxygenases 2007, Krakau, Polen: “Carbon monoxide exerts anti-inflammatory effects in ventilator induced lung injury via PPARy”.
American Thoracic Society, annual meeting 2007, San Francisco, USA: "Anti-inflammatory effects of carbon monoxide in ventilator induced lung injury".
European Society of Anesthesiology, annual meeting 2007, München: "The protective role of carbon monoxide in ventilator induced lung injury", best abstract competition.
European Society of Anesthesiology, annual meeting 2005, Wien, Österreich: “Differential effects of nitric oxide synthases on heme oxygenase-1 in the normal and stress exposed liver”. EJA 2005; 22: S164.
American society of anesthesiologists, annual meeting 2003, San Francisco, USA: “Mechanism of heme oxygenase-1 induction by volatile anesthetics in the liver”
American society of anesthesiologists, annual meeting 2003, San Francisco, USA: “Heme oxygenase-1 suppression by nitric oxide”.
Heme oxygenase / CO Symposium 28. Sep. – 3. Okt. 2003, Uppsala, Schweden: “Regulation of heme oxygenase by volatile anesthetics in the liver”
Deutscher Anaesthesie Kongress 9.-12. April 2003, München. “Induktion der hepatischen Hämoxygenase Typ 1 durch NO-Blockade in der Ratte“.
Deutscher Anaesthesie Kongress 9.-12. April 2003, München. “Mechanismus der Hämoxygenaseregulation durch Isoflurane in der Leber der Ratte.“
Wissenschaftliche Arbeitstage der DGAI, 14.-15. Feb. 2003, Würzburg. “Mechanismus der Hämoxygenaseregulation durch Isoflurane in der Leber der Ratte“.
2 nd Conference on heme oxygenase (HO/CO), 6.-9. Juni 2002, Catania, Italien. “Blockade of endogenous nitric oxide production induces hepatic heme oxygenase-1 expression”.
Wissenschaftliche Arbeitstage der DGAI, 25.-26. Feb. 2002, Würzburg. “Induktion der Hämoxygenase-1 in der Leber der Ratte durch Hemmung der Stickstoffmonoxid-Synthase“.
Shock Society, 3.-6. Juni 2000, Snowbird, USA. ”Effect of nitric oxide on shock-induced hepatic heme oxygenase-1 expression in the rat”. Shock suppl, A 78. 2001.
