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Dr. rer. nat. M. Humar
Publikationen zurück >
Schwer CI, Mutschler M, Goebel U, Stoll P, Humar M, Hoetzel A, Schmidt R. Carbon monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38 MAPK/ HO-1 signaling. Mol Pharmacol. 2010 Apr;77(4):660-669.
Humar M, Graetz C, Roesslein M, Geiger KK, Pannen BH. Heterocyclic thioureylenes protect from calcium dependent neuronal cell death. Mol Pharmacol. 2009 Mar;75(3):667-676.
Humar M, Maurer M, Azemar M, Groner B. DNA vaccination with a mutated p53 allele induces specific cytolytic T cells and protects against tumor cell growth and the formation of metastasis. J Cancer Res Clin Oncol. 2009 Apr;135(4):567-580.
Schwer CI, Guerrero AM, Humar M, Roesslein M, Goebel U, Stoll P, Geiger KK, Pannen BH, Hoetzel A, Schmidt R. Heme oxygenase-1 inhibits the proliferation of pancreatic stellate cells by repression of the ERK1/2 pathway. J Pharmacol Exp Ther. 2008 Dec;327(3):863-71.
Roesslein M, Frick M, Auwaerter V, Humar M, Goebel U, Schwer C, Geiger KK, Pahl HL, Pannen BH, Loop T. Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells. Anesth Analg. 2008 Apr;106(4):1150-60.
Roesslein M, Schibilsky D, Muller L, Goebel U, Schwer C, Humar M, Schmidt R, Geiger KK, Pahl HL, Pannen BH, Loop T. Thiopental protects human T lymphocytes from apoptosis in vitro via the expression of heat shock protein 70. J Pharmacol Exp Ther. 2008 Apr;325(1):217-225.
Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Roesslein M, Schmidt R, Schwer CI, Loop T, Geiger KK, Pahl HL, Pannen BH. Thionamides inhibit the transcription factor NF-kappaB by suppression of the small GTPase Rac1 and IKKalpha. J Pharmacol Exp Ther. 2008 Mar;324(3):1037-44.
Hoetzel A, Welle A, Schmidt R, Loop T, Humar M, Ryter SW, Geiger KK, Choi AM, Pannen BH. Nitric oxide-deficiency regulates hepatic heme oxygenase-1. Nitric Oxide. 2008 Feb;18(1):61-69.
Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Heimrich B, Roesslein M, Schmidt R, Schwer CI, Hoetzel A, Loop T, Pahl HL, Geiger KK, Pannen BH. Repression of T-cell function by thionamides is mediated by inhibition of the activator protein-1/nuclear factor of activated T-cells pathway and is associated with a common structure. Mol Pharmacol. 2007 Dec;72(6):1647-56.
Humar M, Loop T, Schmidt R, Hoetzel A, Roesslein M, Andriopoulos N, Pahl HL, Geiger KK, Pannen BH. The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun. Int J Biochem Cell Biol. 2007;39(12):2278-88.
Schmidt R, Tritschler E, Hoetzel A, Loop T, Humar M, Halverscheid L, Geiger KK, Pannen BH. Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury. Ann Surg. 2007 Jun;245(6):931-42.
Schmidt R, Baechle T, Hoetzel A, Loop T, Humar M, Roesslein M, Geiger KK, Pannen BH. Dihydralazine treatment limits liver injury after hemorrhagic shock in rats. Crit Care Med. 2006 Mar;34(3):815-22.
Hoetzel A, Leitz D, Schmidt R, Tritschler E, Bauer I, Loop T, Humar M, Geiger KK, Pannen BH. Mechanism of hepatic heme oxygenase-1 induction by isoflurane. Anesthesiology. 2006 Jan;104(1):101-9.
Loop T, Dovi-Akue D, Frick M, Roesslein M, Egger L, Humar M, Hoetzel A, Schmidt R, Borner C, Pahl HL, Geiger KK, Pannen BH. Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro. Anesthesiology. 2005 Jun;102(6):1147-57.
Schmidt R, Hoetzel A, Baechle T, Loop T, Humar M, Bauer M, Pahl HL, Geiger KK, Pannen BH. Isoflurane pretreatment lowers portal venous resistance by increasing hepatic heme oxygenase activity in the rat liver in vivo. J Hepatol. 2004 Nov;41(5):706-13.
Loop T, Bross T, Humar M, Hoetzel A, Schmidt R, Pahl HL, Geiger KK, Pannen BH. Dobutamine inhibits phorbol-myristate-acetate-induced activation of nuclear factor-kappaB in human T lymphocytes in vitro. Anesth Analg. 2004 Nov;99(5):1508-15.
Loop T, Scheiermann P, Doviakue D, Musshoff F, Humar M, Roesslein M, Hoetzel A, Schmidt R, Madea B, Geiger KK, Pahl HL, Pannen BH. Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro: potential role of the p38-stress kinase pathway. Anesthesiology. 2004 Sep;101(3):710-21.
Humar M, Andriopoulos N, Pischke SE, Loop T, Schmidt R, Hoetzel A, Roesslein M, Pahl HL, Geiger KK, Pannen BH. Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. Epub 2004 Jul 19.
Humar M, Pischke SE, Loop T, Hoetzel A, Schmidt R, Klaas C, Pahl HL, Geiger KK, Pannen BH. Barbiturates directly inhibit the calmodulin/calcineurin complex: a novel mechanism of inhibition of nuclear factor of activated T cells. Mol Pharmacol. 2004 Feb;65(2):350-61.
Loop T, Humar M, Pischke S, Hoetzel A, Schmidt R, Pahl HL, Geiger KK, Pannen BH. Thiopental inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappaB through suppression of kappaB kinase activity. Anesthesiology. 2003 Aug;99(2):360-7.
Humar M, García-Piñeres AJ, Castro V, Merfort I. Effect of sesquiterpene lactones on the expression of the activation marker CD69 and of IL-2 in T-lymphocytes in whole blood. Biochem Pharmacol. 2003 May 1;65(9):1551-63.
Hoetzel A, Geiger S, Loop T, Welle A, Schmidt R, Humar M, Pahl HL, Geiger KK, Pannen BH. Differential effects of volatile anesthetics on hepatic heme oxygenase-1 expression in the rat. Anesthesiology. 2002 Nov;97(5):1318-21.
Müller MR, Wiesmüller KH, Jung G, Loop T, Humar M, Pfannes SD, Bessler WG, Mittenbühler K. Lipopeptide adjuvants: monitoring and comparison of P3CSK4- and LPS-induced gene transcription. Int Immunopharmacol. 2002 Jul;2(8):1065-77.
Loop T, Liu Z, Humar M, Hoetzel A, Benzing A, Pahl HL, Geiger KK, J Pannen BH. Thiopental inhibits the activation of nuclear factor kappaB. Anesthesiology. 2002 May;96(5):1202-13.
Hoetzel A, Vagts DA, Loop T, Humar M, Bauer M, Pahl HL, Geiger KK, Pannen BH. Effect of nitric oxide on shock-induced hepatic heme oxygenase-1 expression in the rat. Hepatology. 2001 Apr;33(4):925-37.
vd Esche U, Ayoub M, Pfannes SD, Müller MR, Huber M, Wiesmüller KH, Loop T, Humar M, Fischbach KF, Strünkelnberg M, Hoffmann P, Bessler WG, Mittenbühler K. Immunostimulation by bacterial components: I. Activation Of macrophages and enhancement of genetic immunization by the lipopeptide P3CSK4. Int J Immunopharmacol. 2000 Dec;22(12):1093-102.
Martina Maurer-Gebhardt, Marc Azemar, Uwe Altebschmidt, Matjaz Humar, Bernd Groner. Direction of the recognition specificity of cytotoxic T-cells towards tumor cells by transduced, chimeric T cell receptor genes. In: Methods in Molecular Medicine, Ovarian Cancer, Methods and Protocols. 2000 Ed. By John MS Bartlett, Humana Press, pp749.
Gouilleux F, Moritz D, Humar M, Moriggl R, Berchtold S, Groner B. Prolactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor. Endocrinology. 1995 Dec;136(12):5700-8.
