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CCI Walter-Hitzig (formerly Incubator) Fellows
Dr. Christoph Neumann-Haefelin, Walter-Hitzig Fellow 2009
1996-2003 Medical studies, University of Freiburg
Doctoral thesis in the group of Prof. Dr. M. Müller, Institute of Biochemistry, University of Freiburg on “Protein transport in gram-negative bacteria”
Clinical training at the Department of Medicine, University Hospital Freiburg (Director: Prof. Dr. Dres. h.c. H.E. Blum)
2003-2009 Research Associate in the working group of Dr. R. Thimme, Department of Medicine, University Hospital Freiburg on Immunology in hepatitis C virus infection
2009 CCI Incubator fellowship Type II to work on “Analysis of the protective effect of HLA-B27 in hepatitis C virus infection”
2010 Emmy Noether Fellowship
Most Important Publications
Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper M, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen HR, Kim AY, Lauer GM, Allen TM, Barnes E, Roggendorf M, Blum HE, Thimme R (2010). The protective effect of HLA-B27 in hepatitis C virus infection requires presence of a genotype-specific immunodominant CD8+ T cell epitope. Hepatology 51: 54-62.
Viazov S, Ross SS, Kyuregyan KK, Timm J, Neumann-Haefelin C, Isaeva OV, Popova OE, Dmitriev PN, Thimme R, Michailov MI, Roggendorf M (2010). HCV Recombinants Are Rare Even Among Intravenous Drug Users. J Med Virol, 82:232-238.
Dazert E, Neumann-Haefelin C (equal contribution), Bressanelli S, Fitzmaurice K, Kort J, Timm J, McKiernan S, Kelleher D, Gruener N, Tavis JE, Rosen, HR, Shaw J, Bowness P, Blum HE, Klenerman P, , Bartenschlager R, Thimme R (2009). Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response. J Clin Invest 119: 376-386.
Weseslindtner L, Neumann-Haefelin C, Viazov S, Haberstroh A, Kletzmayr J, Aberle JH, Timm J, Ross SR, Klauser-Braun R, Baumert TF, Roggendorf M, Thimme R, Holzmann H (2009). Acute infection with a single hepatitis C virus strain in dialysis patients: analysis of adaptive immune response and viral variability. J Hepatol 50:693-704.
Neumann-Haefelin C, Timm J, Spangenberg HC, Wischniowski N, Nazarova N, Kersting N, Roggendorf M, Allen TM, Blum HE, Thimme R (2008). Virological and Immunological Determinants of Intrahepatic Virus-Specific CD8+ T-Cell Failure in Chronic Hepatitis C Virus Infection. Hepatology 47: 1824-1836.
Neumann-Haefelin C, Frick DN, Wang JJ, Pybus OG, Salloum S, Narula GS, Eckart A, Biezynski A, Eiermann T, Klenerman P, Viazov S, Roggendorf M, Thimme R, Reiser M, Timm J (2008). Analysis of the evolutionary forces in an immunodominant CD8 epitope in the hepatitis C virus at a population level. J Virol. 82: 3438-3451.
Neumann-Haefelin C, Killinger T, Timm J, Southwood S, McKinney D, Blum HE, Thimme R (2007). Absence of viral escape within a frequently recognized HLA-A26 restricted CD8+ T cell epitope targeting the functionally constrained hepatitis C virus NS5A/5B cleavage site. J Gen Virol. 88: 1986-1991.
Neumann-Haefelin C, McKiernan S, Ward S, Viazov S, Spangenberg HC, Killinger T, Baumert TF, Nazarova N, Sheridan I, Pybus O, von Weizsacker F, Roggendorf M, Kelleher D, Klenerman P, Blum HE, Thimme R (2006). Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution. Hepatology 43: 563-572.
Neumann-Haefelin C, Schäfer U, Muller M, Koch HG (2000). SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein. EMBO J 19: 6419-6426.
