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CCI Walter-Hitzig Fellows Type 1
Dr. Sybille Kenzel, Walter-Hitzig Fellow 2/2010-4/2010
2001-2007 Medical school, University of Freiburg, Germany
2/2005 Visiting Junior Scientist, Division of Infectious Diseases, Dept. of Medicine, University of Massachusetts, Worcester, USA
2003-2007 Doctorial thesis, Pediatric Infectious Diseases; Center for Pediatrics and Adolescent Medicine, University of Freiburg, Germany
2007-2010 Residency in the Dept. of Pediatrics, University Hospital Freiburg, Germany
2009-2010 Clinical Fellowship at the Centre of Chronic Immunodeficiency (CCI), Freiburg, Germany
07/2010 to 12/2010 Resident at the Department for Neonatology, Universitätklinikum Magdeburg, Germany.
2011- Postdoctoral Physician Scientist at Institute for Medical Immunology and Berlin-Brandenburg Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Germany
Most Important Publications
Kenzel S, Mancuso G, Malley R, Teti G, Golenbock DT, Henneke P 2006 c-Jun kinase is a critical signaling molecule in a neonatal model of group B streptococcal sepsis. J Immunol 2006 176:3181-8.
Kenzel S, Henneke P 2006 The innate immune system and its relevance to neonatal sepsis. Curr Opin Infect Dis 2006.19:264-70.
Kenzel S, Santos-Sierra S, Deshmukh SD, Moeller I, Ergin B, Fitzgerald KA, Lien E, Akira S, Golenbock DT, Henneke P 2009 Role of Egr-1 in the macrophage response to Group B streptococcus. Infect Immun 2009 Jun;77:2474-81.
Dr. Jan Rohr, Walter-Hitzig Fellow 9/2010-2/2011
1997-2003 Medical school, University of Mainz, Germany
2000-2004 Medical school, University of Heidelberg, Germany
2003 Doctoral thesis “The influence of inflammatory cytokines on hematopoetic progenitor cell derived neonatal dendritic cells and the type of T-cell activation”. Laboratory of Pediatric Immunology and Vaccinology (Prof. Fred Zepp), University of Mainz, Germany
2004-2010 Residency in the Dept. of Pediatrics, University Hospital Freiburg
2010 Fellowship at the Centre of Chronic Immunodeficiency (CCI), Freiburg, Germany
2011 Postdoc Fellowship, Ton Schumacher group, National Cancer Institute, Amsterdam, Netherlands
Most Important Publications
Rohr, J*, Pannicke U*, Döring M, Schmitt-Graeff A, Wiech E, Speckmann C, Müller I, Lang P, Handgretinger R, Fisch P, Schwarz K, Ehl S. Chronic inflammatory bowel disease is a new phenotype of atypical ARTEMIS deficiency. *equal contribution – J Clin Immunol, 2010 30:314-20
Pannicke U, Hönig M, Schulze I, Rohr J, Heinz G, Braun S, Janz I, Rump EM, Seidel MG, Matthes-Martin S, Soerensen J, Albert MH, Belohradsky BH, Schulz A, Ehl S, Friedrich W, Schwarz K. The most frequent DCLRE1C (ARTEMIS) mutations are based on homologous recombination events. Human Mutation – 2010 31:197-207
zur Stadt U, Rohr J, Seifert W, Koch F, Grieve S, Pagel J, Strauß J, Kasper B, Nürnberg G, Becker C, Maul-Pavicic A, Beutel K, Janka G, Griffiths G, Ehl S, Hennies HC. Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11. Am J Hum Genet. 2009 Oct;85(4):482-92.
Rohr JC, Wagner HJ, Lauten M, Wacker HH, Jüttner E, Hanke C, Pohl M, Niemeyer CM. Differentiation of EBV-induced post-transplant Hodgkin lymphoma from Hodgkin-like post-transplant lymphoproliferative disease. Pediatr Transplant. 2008 Jun;12(4):426-31. .
Dr. Kerstin Felgentreff, Walter-Hitzig Fellow 1/2011-3/2011
2001-2007 Medical school, Phillips-University, Marburg, Germany
2004 -2008 Doctoral thesis, Dept. of Pulmonology, Internal Medicine, Phillips-University, Marburg, Germany
2008-2009 Residency in the Dept. of Pediatrics, University Hospital Freiburg, Germany (Professor U. Frei)
2009-2011 Clinical Fellowship at the Centre of Chronic Immunodeficiency (CCI), Freiburg, Germany
2011- Research Fellow in Pediatrics, Children's Hospital Boston, USA
Most Important Publications
Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R. Allergic airway inflammation inhibits pulmonary antibacterial host defense. J Immunol. 2006; 177(3):1833-7.
Felgentreff K, Beisswenger C, Griese M, Gulder T, Bringmann G, Bals R. The antimicrobial peptide cathelicidin interacts with airway mucus. Peptides 2006; 27(12):3100-6.
Felgentreff K, Schupp W, Otten JE, Rückauer KD, Uhl M, Jüttner E, Superti-Furga A, Pohl M. Inspiratory stridor and dysphagia in two newborn infants caused by ectopic thymus tissue. Eur J Pediatr. 2009; 168:1141-1145.
Dr. Susan Farmand, Walter-Hitzig Fellow 7/2011-12/2011
1999-2006 Medical school, University of Freiburg and University of Bonn, Germany
2002-2003 Medical school, University of Perugia, Italy (Erasmus-Programme)
2006 4 month internships at the University of Michigan, USA and at the University of Copenhagen, Denmark
2004-2007 Doctoral thesis, Neurology, Dept. of Neurology, University of Bonn, Germany
2007-2011 Pediatrics Residency in the Centre of Paediatric and Adolescent Medicine, University Hospital Freiburg, Germany
2010-2011 Clinical Fellowship at the Centre of Chronic Immunodeficiency (CCI), Freiburg, Germany
2012- Research Fellowship at the Karolinska Institute, Stockholm, Sweden
Most Important Publications
Farmand S, Henneke P, Hufnagel M, Berner R. Significant decline in the erythromycin resistance of group A streptococcus isolates at a German paediatric tertiary care centre. Eur J Clin Microbiol Infect Dis. 2011 Jul 28. [Epub ahead of print]
Farmand S, Wirth S, Löffler H, Woltering T, Kenzel S, Lainka E, Henneke P.Spontaneous clearance of hepatitis C virus in vertically infected children. Eur J Pediatr. 2011 Jul 7. [Epub ahead of print]
Semmler A, Farmand S, Moskau S, Stoffel-Wagner B, Linnebank M. The G Allele of Transcobalamin 2 c.776C→G Is Associated with an Unfavorable Lipoprotein Profile. Ann Nutr Metab. 2010, 57:112-115.
Linnebank M, Moskau S, Farmand S, Fliessbach K, Kölsch H, Bös M, Grothe C, Becker D, Harbrecht U, Pohl C, Wüllner U, Klockgether T. Homocysteine and carotid intima-media thickness in a german population: lack of clinical relevance. Stroke. 2006 37:2840-2.
Dr. Jens Thiel, Walter-Hitzig Fellow 12/2011-5/2012
1994-2001 Medical school, University of Freiburg, Germany
1999-2002 Doctoral thesis “Influence of immunosuppressive therapy on Hepatitis C virus associated autoimmune phenomena and HCV quasispecies”. Department of Rheumatology and Clinical Immunology (Prof. H.H. Peter), University of Freiburg, Germany
2002-present Residency in the Dept. of Rheumatology, University Hospital Freiburg
2008-present Fellowship at the Centre of Chronic Immunodeficiency (CCI), Freiburg, Germany
Most Important Publications
Thiel J, Kimmig L, Salzer U, Grudzien M, Lebrecht D, Hagena T, Draeger R, Völxen N, Bergbreiter A, Jennings S, Gutenberger S, Aichem A, Illges H, Hannan JP, Kienzler AK, Rizzi M, Eibel H, Peter HH, Warnatz K, Grimbacher B, Rump JA, Schlesier M. Genetic CD21 deficiency is associated with hypogammaglobulinemia. J Allergy Clin Immunol. 2011 Oct 27.
Kreuzaler M, Rauch M, Salzer U, Birmelin J, Rizzi M, Grimbacher B, Plebani A, Lougaris V, Quinti I, Thon V, Litzman J, Schlesier M, Warnatz K, Thiel J, Rolink AG, Eibel H. Soluble BAFF Levels Inversely Correlate with Peripheral B Cell Numbers and the Expression of BAFF Receptors. J Immunol. 2012 Jan 1;188(1):497-503.
Engelhardt KR, McGhee S, Winkler S, Sassi A, Woellner C, Lopez-Herrera G, Chen A, Kim HS, Lloret MG, Schulze I, Ehl S, Thiel J, Pfeifer D, Veelken H, Niehues T, Siepermann K, Weinspach S, Reisli I, Keles S, Genel F, Kutukculer N, Camcioğlu Y, Somer A, Karakoc-Aydiner E, Barlan I, Gennery A, Metin A, Degerliyurt A, Pietrogrande MC, Yeganeh M, Baz Z, Al-Tamemi S, Klein C, Puck JM, Holland SM, McCabe ER, Grimbacher B, Chatila TA. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol. 2009 Dec;124(6):1289-302
Bohn G, Allroth A, Brandes G, Thiel J, Glocker E, Schäffer AA, Rathinam C, Taub N, Teis D, Zeidler C, Dewey RA, Geffers R, Buer J, Huber LA, Welte K, Grimbacher B, Klein C. A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14. Nat Med. 2007 Jan;13(1):38-45. Epub 2006 Dec 31.
Thiel J, Peters T, Mas Marques A, Rösler B, Peter HH, Weiner SM. Kinetics of hepatitis C (HCV) viraemia and quasispecies during treatment of HCV associated cryoglobulinaemia with pulse cyclophosphamide. Ann Rheum Dis. 2002 Sep;61(9):838-41.
