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CCI Incubator Fellows
Dr. Yakup Tanriver, Walter-Hitzig Fellow 3/2010-2/2012
1994-2001 Medical studies, Humboldt-University, Berlin, Germany
2002 Doctoral thesis on “Influence of hypertension and the renin angiotensin aldosteron system on chronic allograft dysfunction”
2002-2005 Clinical training at the Charite Campus Virchow, Nephrology and Medical Intensive Care Berlin, Germany (Professor U. Frei)
2005-2008 Postdoctoral research fellow in the lab of Robert Lechler, Kings College, London working on exploitation of naturally occurring regulatory T cells to induce longterm allograft survival, antibody mediated targeting of splenic dendritic cells with alloantigen derived peptides and induction and activation of regulatory T cells in vivo and the influence of costimulation molecules.
2009 Senior resident University Hospital Freiburg, Medical Clinic IV Nephrology und General Medicine Freiburg, (Professor G. Walz)
2010 CCI Incubator fellowship Type II to work on “The role of NKG2D on T cells during allograft recognition and rejection” in Andreas Diefenbach's group
2012 Research fellow, Dept. Nephrology, Medical Clinic IV Nephrology und General Medicine Freiburg
Most Important Publications
Tanriver Y, Ratnasothy K, Lombardi G, Lechler RI. Targeting MHC class I monomers to dendritic cells inhibits the indirect pathway of allorecognition and the production of IgG alloantibodies leading to long-term allograft survival. J Immunol. 2010:184:1757-64
Tanriver Y, Martín-Fontecha A, Ratnasothy K, Lombardi G, Lechler RI. Superantigen activated regulatory T cells inhibit the migration of innate immune cells and the differentiation of naïve T cells. J Immunol. 2009 183(5):2946-56.
Tsang J*, Tanriver Y*, Jiang S, Leung E, Ratnasothy K, Lombardi G, Lechler RI. Indefinite mouse heart allograft survival in recipient treated with CD4+CD25+ regulatory T cells with indirect allospecificity and short term immunosuppression. Transpl Immunol. 2009 Sep;21(4):203-9. *Joint first authorship
Tsang J, Tanriver Y, Jiang S, Leung E, Ratnasothy K, Lombardi G, Lechler RI. Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favours transplantation tolerance in mice. J Clin Invest. 2008:118(11):3619-28.
Tsang J, Jiang S, Tanriver Y, Leung E, Lombardi G, Lechler RI. In-vitro generation and characterisation of murine CD4+CD25+ regulatory T cells with indirect allospecificity. Int Immunopharmacol. 2006 Dec 20;6(13-14):1883-8.
Schindler R, Tullius SG, Tanriver Y, Noack K, Qun Y, Jürgensen JS, Frei U. Hypertension increases expression of growth factors and MHC II in chronic allograft nephropathy. Kidney Int. 2003 Jun;63(6):2302-8.
Schindler R, Tanriver Y, Frei U. Hypertension and allograft nephropathy--cause, consequence, or both? Nephrol Dial Transplant. 2000 Jan;15(1):8-10.
