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Translational Research Platforms

B-Cell-Platform

• B 1: Early B cell development in adult onset primary antibody deficiency (PAD)
  Rizzi, Salzer
   
• B 2: Intrinsic defects impeding B cell activation and differentiation in CVID
  Warnatz
   
• B 3: Ig-α in Plasma Cell Survival
  Hobeika
   
• B 4: The role of IL10 signalling for B cells, the importance of IL10 for the T and B cell interaction, and its role in CVID enteropathy
  Grimbacher, Glocker
   
• B 5: Role of chemokine receptors in B cell maturation processes
  Burger
   
• B 6: B Lymphocyte-Specific Modulation of Intracellular Signaling Pathways Using the “Ligand- Sneaking” Strategy: Investigation of NF-κB Signaling in Plasma Cell Development
  Eibel, Voll
   

T-Cell-Platform

• T 1: Establishment of an Analytical Platform: Molecular Analysis of T-Cell Signaling Networks in Patients with Combined Immunodeficiencies
  Ehl, Schamel, Blumenthal
   
• T 2: Molecular and functional analysis of TGF-β receptor mutations in human CD4+ T cells
  Beck
   
• T 3: The role of SHIP and the PI3K pathway in CD3γ-immunodeficiencies
  Schamel
   
• T 4: Correlation of immune phenotype (“immunotype”) and disease development in different mouse models of hemophagocytic lymphohistiocytosis (HLH)
  Aichele
   
• T 5: Phenotype and function of virus-specific CD8+ T cells in patients with T cell deficiencies CCI Platform
  Thimme
   
• T 6: PTC124 as therapy for severe combined immunodeficiency
  Ehl, Schwarz
   

Platform Innate Immune Cells

• IN 1: The role of IL-17-producing innate lymphoid cells and neutrophils for the pathogenesis of the hyper-IgE- syndrome
  Diefenbach, Häcker
   
• IN 2: MyD88 deficiency: Role of myeloid cell networks in susceptibility to Staphylococcus aureus infections
  Henneke, Triantafyllopoulou, Hübner, Prinz
   

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