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Antiviral T cells - T cell immunity to infection with respiratory syncytial virus in mice (RSV)
Summary
Respiratory syncytial virus (RSV) causes significant morbidity and mortality in infants, immunocompromised adults and the elderly. The nature and severity of disease vary widely between infected individuals. Viral, host and environmental factors probably all contribute to this variable disease expression. However, it remains unclear, how and to which extent these factors really contribute to disease pathogenesis. Both in humans and in mice, cytotoxic T cells (CTL) have been identified as important mediators of virus control and disease. Infants with congenital T cell deficiencies can not eliminate RSV and depletion of T cells leads to persistent infection in BALB/c mice.
The extent and composition of the CTL response to viruses is determined by the MHC haplotype and the viral T cell epitope configuration. We currently address the question to which extent these factors determine disease susceptibility after RSV infection of mice. For this we have introduced a single amino acid substitution into the RSV sequence that abrogates activation of an otherwise immunodominant CTL population. Furthermore, we follow the observation of different disease susceptibility in C57BL/6 versus BALB/c mice and use MHC congenic mice to analyze the contribution of the MHC to RSV-specific CTL responses and disease.
Cooperation Partners
- Christine Krempl, Institut für Virologie, Universität Würzburg
- Peter Staehli, Abteilung Virologie, Institut für Mikrobiologie und Hygiene, Uniklinik Freiburg
- Dieter Neumann-Haefelin, Abteilung Virologie, Institut für Mikrobiologie und Hygiene, Uniklinik Freiburg
- Peter Collins, NIH, Bethesda, Maryland, USA
Funding
SFB 620, TPA4, Deutsche Forschungsgesellschaft
"Aktivierung, Differenzierung und Migration von Virus-spezifischen CD8+ T-Zellen während pulmonaler Infektion mit Respiratory Syncytial Virus (RSV)"
Publications
For an up-to-date list of publications by Prof. Stephan Ehl please see the PubMed search:
