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ICL- Idiopathic CD4 Lymphocytopenia
Summary
Idiopathic CD4 Lymphocytopenia (ICL) was first described by the Center of Disease Control in 1993 as a HIV-negative immunodeficiency characterized by the reduction of CD4 T cells below 300/µl or 20% of T cells. Like in HIV infection patients often manifest with opportunistic infections. Despite numerous case reports, little systematic research of this rare immunodeficiency has been performed in order to elucidate the underlying immunologic condition.
Publications
Walker, U. A., and K. Warnatz. 2006. Idiopathic CD4 lymphocytopenia. Curr. Opin. Rheumatol. 18:389.
Warnatz, K., R. Draeger, M. Schlesier, and H. H. Peter. 2000. Successful IL-2 therapy for relapsing herpes zoster infection in a patient with idiopathic CD4+ T lymphocytopenia. Immunobiology 202:204.
