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Clinical Research (Studies)

The design and assembly of (inter)national patient cohorts is the first step towards clinical and research studies on the improvement of diagnosis and treatment of immunodeficiencies. Not all of these patient cohorts are based within the CCI. Some will be supervised in cooperation with other internal and external facilities in regard to chronic immunodeficiency.

Primary Immunodeficiency Patient Cohorts

CVID   Patients with common variable immunodeficiency
STILPAD Patients with common variable immunodeficiency (CVID) and interstitial lung disease
ICL Patients with idiopathic low CD4 syndrome
ALPS   Patients with chronic, non-malignant lymhoproliferation and autoimmune cytopenia in at least one cell type or patients with either lymhoproliferation or autoimmune cytopenia with an increase in “double negative” T cells
XIAP Patients with X-linked Lymphoproliferative syndrome type-2 (XLP-2)
HLH   Patients with haemophagocytic lymphohistiocytosis or macrophage-activation syndrome
P-CID   Patients with profound combined immunodeficiency
Loeys-Dietz Syndrome Patients with a connective tissue disorder caused by mutations in the transforming growth factor beta receptor I or II (TGFBRI of TGFBRII)

Acquired Immunodeficiency Patient cohorts

Asplenie Patients with asplenia for either anatomical or functional reasons
Spleen-Off Patients with asplenia for either anatomical or functional reasons and OPSI

Pathogen-Defined Cohorts

HIV Patients with HIV infection
NTM-Kids Children with cervical lymphadenopathy with a suspected or confirmed infection with non-tubercular mycobacteria
Staph. aureus Patients with S. aureus bacteriaemia, localised S. aureus infection or mucocutaneous S. aureus-colonisation

Pupulation-based studies

AWIS Incidence of respiratory tract infections in the general population (Link in German)
AWIS-PLUS Comparative study between a high and a low respiratory tract infection-prone group (Link in German)
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