Original Publications, fulltext in members area

• Olk-Batz C, Poetsch AR, Nöllke P, Claus R, Zucknick M, Sandrock I, Witte T, Strahm B, Hasle H, Zecca M, Stary J, Bergstraesser E, De Moerloose B, Trebo M, van den Heuvel-Eibrink MM, Wojcik D, Locatelli F, Plass C, Niemeyer CM, Flotho C.:
  Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia (JMML) with poor outcome.
  Blood. 2011 Mar 15. [Epub ahead of print] (link to journal)
  
  
• Strahm B, Nöllke P, Zecca M, Korthof ET, Bierings M, Furlan I, Sedlacek P, Chybicka A, Schmugge M, Bordon V, Peters C, O'Marcaigh A, de Heredia CD, Bergstraesser E, Moerloose BD, van den Heuvel-Eibrink MM, Starý J, Trebo M, Wojcik D, Niemeyer CM, Locatelli F.:
  Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome in children: results of the EWOG-MDS 98 study.
  Leukemia (2011) 25, 455–462 (link to journal)
  
  
• Madureira AB, Eapen M, Locatelli F, Teira P, Zhang MJ, Davies SM, Picardi A, Woolfrey A, Chan KW, Socié G, Vora A, Bertrand Y, Sales-Bonfim CM, Gluckman E, Niemeyer C, Rocha V:
  Analysis of risk factors influencing outcome in children with myelodysplastic syndrome after unrelated cord blood transplantation.
  Leukemia (2011) 25, 449–454 (link to journal)
  
  
• Göhring G, Michalova K, Beverloo HB, Betts D, Harbott J, Haas OA, Kerndrup G, Sainati L, Bergstraesser E, Hasle H, Stary J, Trebo M, van den Heuvel-Eibrink MM, Zecca M, van Wering ER, Fischer A, Noellke P, Strahm B, Locatelli F, Niemeyer CM, Schlegelberger B.:
  Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome.
  Blood November 11, 2010 vol. 116 no. 19 3766-3769 (link to journal)
  
  
• Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Sakamoto KM, Gorr TA, Mehta P, Schmid I, Kropshofer G, Corbacioglu S, Lang PJ, Klein C, Schlegel PG, Heinzmann A, Schneider M, Starý J, van den Heuvel-Eibrink MM, Hasle H, Locatelli F, Sakai D, Archambeault S, Chen L, Russell RC, Sybingco SS, Ohh M, Braun BS, Flotho C, Loh ML:
  Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.
  Nat Genet. 2010 Sep;42(9):794-800. Epub 2010 Aug 8 (link to journal)
  
  
• Silvia Bresolin, Marco Zecca, Christian Flotho, Luca Trentin, Andrea Zangrando, Laura Sainati, Jan Stary, Barbara de Moerloose, Henrik Hasle, Charlotte M. Niemeyer, Geertruy te Kronnie, Franco Locatelli, and Giuseppe Basso:
  Gene Expression–Based Classification As an Independent Predictor of Clinical Outcome in Juvenile MyelomonocyticLeukemia.
  JCO, 2010 Mar 10.1200/JCO.2009.24.4426 (link to journal)
  
  
• Mignon L. Loh, Debbie S. Sakai, Christian Flotho, Michelle Kang, Manfred Fliegauf, Sophie Archambeault, Charles G. Mullighan, Leslie Chen, Eva Bergstraesser, Carlos E. Bueso-Ramos, Peter D. Emanuel, Henrik Hasle, Jean-Pierre Issa, Marry M. van den Heuvel-Eibrink, Franco Locatelli, Jan Stary´, Monica Trebo, Marcin Wlodarski, Marco Zecca, Kevin M. Shannon, and Charlotte M. Niemeyer:
  Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.
  Blood. 2009 August 27; 114(9):1859-63 (link to journal)
  
  
• Karow A, Flotho C, Schneider M, Fliegauf M, Niemeyer CM:
  Mutations of the Shwachman-Bodian-Diamond syndrome (SBDS) gene in patients presenting with refractory cytopenia - do we have to screen?
  Haematologica. 2009 Nov 30 (link to journal)
  
  
• Furlan I, Batz C, Flotho C, Mohr B, Lübbert M, Suttorp M, Niemeyer CM:
  Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7.
  Blood. 2009 Mar 19;113(12):2867-8 (link to journal)
  
  
• Flotho C, Kratz CP, Bergstraesser E, Hasle H, Stary J, Trebo M, van den Heuvel-Eibrink MM, Wójcik D, Zecca M, Locatelli F, Niemeyer CM:
  Genotype-phenotype correlation in cases of juvenile myelomonocytic leukemia with clonal RAS mutations.
  Blood 111(2): 966-967, 2008 (link to journal)
  
  
• de Vries ACH, Stam RW, Kratz CP, Zenker M, Niemeyer CM, van den Heuvel-Eibrink MM:
  Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia.
  Haematologica 92(11): 1557-1560, 2007 (link to journal)
  
  
• Strahm B, Locatelli F, Bader P, Ehlert K, Kremens B, Zintl F, Führer M, Stachel D, Sykora KW, Sedlacek P, Baumann I, Niemeyer CM:
  Reduced intensity conditioning in unrelated donor transplantation for refractory cytopenia in childhood.
  Bone Marrow Transplant. 2007 Aug;40(4):329-33 (link to journal)
  
  
• Starý J, Baumann I, Creutzig U, Harbott J, Michalova K, Niemeyer C.:
  Getting the numbers straight in pediatric MDS: Distribution of subtypes after exclusion of down syndrome.
  Pediatr Blood Cancer Volume 50, Issue 2, 435-436, 2008 Feb (link to journal)
  
  
• Zecca M, Begamaschi G, Bergsträßer E, Danesino C, De Filippi P, Hasle H, Kratz C, Lisini D, Locatelli F, Pession A, Sainati L, Starý J, Trebo M, van den Heuvel-Eibrink M, Wójcik D, Niemeyer CM:
  V617F JAK2 gene mutation is a rare event in juvenile myelomonocytic leukemia.
  Leukemia 21 (2) : 367-369, 2007 (link to journal)
  
  
• Yoshimi A, Baumann I, Führer M, Bergsträsser E, Göbel U, Sykora KW, Klingebiel T, Gross-Wieltsch U, van den Heuvel-Eibrink M, Fischer A, Nöllke P, Niemeyer CM:
  Immunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia.
  Haematologica. 2007 Mar;92(3):397-400 (link to journal)
  
  
• Hasle H, Alonzo TA, Auvrignon A, Behar C, Chang M, Creutzig U, Fischer A, Forestier E, Fynn A, Haas OA, Harbott J, Harrison CJ, Heerema NA, van den Heuvel-Eibrink MM, Kaspers GJ, Locatelli F, Noellke P, Polychronopoulou S, Ravindranath Y, Razzouk B, Reinhardt D, Savva NN, Stark B, Suciu S, Tsukimoto I, Webb DK, Wojcik D, Woods WG, Zimmermann M, Niemeyer CM, Raimondi SC:
  Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study.
  Blood, Jun 2007; 109: 4641 - 4647 (link to journal)
  
  
• Yoshimi A, Mohamed M, Bierings M, Urban C, Korthof E, Zecca M, Sykora K-W, Duffner U, Trebo M, Matthes´-Martin S, Sedlacek P, Klingebiel T, Lang P, Führer M, Claviez A, Wössmann W, Pession A, Arvidson J, o’Marcaigh AS, van den Heuvel-Eibrink MM, Hasle H, Nöllke P, Locatelli F, Niemeyer CM:
  Second allogeneic hematopoietic stem cell transplantation (HSCT) results in outcome similar to that of first HSCT for patients with juvenile myelomonocytic leukemia.
  Leukemia 21(3): 556-560, 2007 (link to journal)
  
  
• Bergstraesser E, Hasle H, Rogge T, Fischer A, Zimmermann M, Noellke P, Niemeyer CM:
  Treatment of juvenile myelomonocytic leukemia other than hematopoietic stem cell transplantation: a retrospective analysis and definition of response criteria.
  Pediatric Blood & Cancer 49 (5): 629-633, 2007 Oct (link to journal)
  
  
• Ayami Yoshimi, Charlotte M Niemeyer, Viktoria Bohmer, Ulrich Duffner, Brigitte Strahm, Hermann Kreyenberg, Dagmar Dilloo, Felix Zintl, Alexander Claviez, Willi Wössmann, Bernhard Kremens, Wolfgang Holter Dietrich Niethammer, James Beck, Udo Kontny, Peter Nöllke, Thomas Klingebiel, Peter Bader:
  Chimerism analyses and subsequent immunological intervention after stem cell transplantation in patients with juvenile myelomonocytic leukaemia.
  British Journal of Haematology, 2005;129:542-549 (link to journal)
  
  
• Ayami Yoshimi, Peter Bader, Susanne Matthes-Martin, Jan Starý, Peter Sedlacek, Ulrich Duffner, Thomas Klingebiel, Dagmar Dilloo, Wolfgang Holter, Felix Zintl, Bernhard Kremens, Karl-Walter Sykora, Christian Urban, Henrik Hasle, Elisabeth Korthof, Tom Révész, Alexandra Fischer, Peter Nöllke, Franco Locatelli, Charlotte M Niemeyer:
  
  Donor leukocyte infusion after hematopoietic stem cell transplantation in patients with juvenile myelomonocytic leukemia.
  Leukemia, 2005;19:971-977 (link to journal)
  
  
• Henrik Hasle, Irith Baumann, Eva Bergsträsser, Susanna Fenu, Gabriella Kardos, Gitte Kerndrup, Franco Locatelli, Georg Mann, Tim Rogge, Kirk R. Schultz, Jan Starý, Marry van den Heuvel-Eibrink, Jochen Harbott, Peter Nöllke, Charlotte M. Niemeyer:
  The international prognostic scoring system (IPSS) for childhood myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML).
  Leukemia, 2004, 18, pp. 2008-2014 (link to journal)
  
  
• Franco Locatelli, Peter Nöllke, Marco Zecca, Elisabeth Korthof, Edoardo Lanino, Christina Peters, Andrea Pession, Hartmut Kabisch, Cornelio Uderzo, Carmen S Bonfim, Peter Bader, Dagmar Dilloo, Jan Stary, Alexandra Fischer, Tom Revesz, Monika Fuhrer, Henrik Hasle, Monika Trebo, Marry M van den Heuvel-Eibrink, Susanna Fenu, Brigitte Strahm, Giovanna Giorgiani, Mario R Bonora, Ulrich Duffner, and Charlotte M Niemeyer:
  Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial.
  Blood, Sep 2004; 10.1182/blood-2004-05-1944 (link to journal)
  
  
• Gabriela Kardos, Irith Baumann, S. Jane Passmore, Franco Locatelli, Henrik Hasle, Kirk R. Schultz, Jan Starý, Annette Schmitt-Graeff, Alexandra Fischer, Jochen Harbott, Judith M. Chessells, Ian Hann, Susanna Fenu, Angelo Cantú Rajnoldi, Gitte Kerndrup, Elisabeth van Wering, Tim Rogge, Peter Nöllke, Charlotte M. Niemeyer:
  A Refractory Anemia in Childhood: A Retrospective Analysis of 67 Cases with Particular Reference to Monosomy 7.
  Blood, 15 September 2003, Vol. 102, No. 6, pp. 1997-2003 (link to journal)
  
  
• Tartaglia M, Niemeyer CM, Fragale A, Song X, Buechner J, Jung A, Hählen K, Hasle H, Licht JD, Gelb BD:
  Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.
  Nature Genetics, Published online: 28 April 2003, doi:10.1038/ng1156 (link to journal)
  
  
• Hasle H, Niemeyer CM, Chessells JM, Baumann I, Bennett JM, Kerndrup G, Head DR:
  A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases.
  Leukemia 17(2):277-82, 2003 (link to journal)
  
  
• Hasle H, Aricó M, Biondi A, Cantú Rajnoldi A, Creutzig U, Fenu S, Fonatsch C, Haas OA, Harbott J, Kerndrup G, Mann G, Niemeyer CM, Ptoskova H, Ritter J, Slater R, Stary J, Stollmann-Gibbels B, Testi AM, van Wering ER, and Zimmermann M:
  Myelodysplastic syndrome and acute myeloid leukemia associated with complete or partial monosomy 7.
  Leukemia 13(3):376-385, 1999 (link to journal)
  
  
• Donald Pinkel;, Maurizio Aricò, Andrea Biondi, Ching-Hon Pui;, C.M. Niemeyer, S. Fenu, H. Hasle, G. Mann, J. Stary, and E. van Wering:
  Differentiating Juvenile Myelomonocytic Leukemia From Infectious Disease.
  Blood 91(1): 365-367, 1998 (link to journal)
  
  
• Niemeyer CM, Aricó M, Biondi A, Basso G, Cantú Rajnoldi A, Creutzig U, Haas O, Harbott J, Hasle H, Kerndrup G, Locatelli F, Mann G, Stollmann-Gibbels B, van't Veer-Korthof ET, van Wering E, Zimmermann M:
  Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases.
  Blood 89(10):3534-3543, 1997 (link to journal)
  
  
• Locatelli F, Niemeyer C, Angelucci E, Bender-Götze C, Burdach S, Wolfram E, Friedrich W, Hasle H, Hermann J, Jacobsen N, Klingebiel T, Kremens B, Pession A, Peters C, Schmid HJ, Stary J, Suttorp M, Uderzo C, van't Veer-Korthof ET, Vossen J, Zecca M, Zimmermann M:
  Allogeneic bone marrow transplantation for chronic myelomonocytic leukemia in childhood: a report from the European Working Group on Myelodysplastic Syndrome in Childhood (EWOG-MDS).
  J Clin Oncol 15(2):566-573, 1997 (link to journal)