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Central and Effector memory T cells
Investigators:
Katja Müller and Hanspeter Pircher
Based on expression of CD62L and the chemokine receptor CCR7, memory T cells have been divided into two main subsets: central memory T cells (TCM) expressing both CD62L and CCR7 and effector memory cells (TEM) lacking CD62L/CCR7 cell surface expression. In this project, we are studying the biology of central and effector memory T cells using the murine model of lymphocytic choriomeningitis virus (LCMV) infection and transgenic mice expressing a LCMV specific T cell receptor.
References:
Unsoeld, H., Mueller, K., Schleicher, U., Bogdan, C., Zwirner, J., Voehringer, D., and Pircher, H. 2007. Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections. Int. Immunol. 19:1281
Unsoeld, H. and H. Pircher. 2005. Complex memory T cell phenotypes revealed by co-expression of CD62L and CCR7. J. Virology 79: 4510
Unsoeld, H., D. Voehringer, S. Krautwald, and H. Pircher. 2004. Constitutive expression of CCR7 directs effector CD8 T cells into the splenic white pulp and impairs functional activity. J Immunol 173:3013.
Unsoeld, H., S.Krautwald, D. Voehringer, U. Kunzendorf and H. Pircher. 2002. CCR7+ and CCR7- memory T cells do not differ in immediate effector cell function. Cutting edge: J Immunol. 169:638
