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T cell immunity against tumors
Investigators:
Katja Müller and Hanspeter Pircher
We have established different tumor models using a defined tumor-associated antigen that allows to study the anti-tumor T cell responses in normal and T cell receptor (TCR) transgenic mice. B16.F10 melanoma cells, 3LL-A9 Lewis lung carcinoma cells or MCA102 fibrosarcoma cells were transfected with a minigene encoding the sequence of residues 33 to 41 (GP33 peptide) of the glycoprotein from lymphocytic choriomeningitis virus (LCMV).
Using these models we are now addressing the following questions:
- can adoptively transferred GP33-specific T cells induce tumor regression ?
- which effector mechanisms are involved ?
- can tumor cells tolerize T cells?
References:
Blohm U., D. Potthoff, A. van der Kogel and H. Pircher. 2006. Solid tumors "melt" from the inside after successful CD8 T cell attack. Eur J Immunol.36:468.
Blohm U., E. Roth, K. Brommer, T. Dumrese, F. Rosenthal, and H. Pircher. 2002. Lack of Effector Cell Function and Altered Tetramer Binding of Tumor-Infiltrating Lymphocytes J Immunol 169:5522
Prevost-Blondel A, Roth E, Rosenthal FM, Pircher H.:Crucial role of TNF-a in CD8 T cell-mediated elimination of 3LL-A9 Lewis lung carcinoma cells in vivo. 2000, J.Immunol. 164:3645-3651
Prevost-Blondel A, Neuenhahn M, Rawiel M,, Pircher H. Differential requirement of perforin in CD8 T cell-mediated immune responses against B16. F10 melanoma cells expressing a viral antigen. 2000, Eur.J.Immunol. 30: 2507-2515
