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Function of the NK receptor KLRG1 in mice and humans
Investigators:
Carsten Gründemann, Sabrina Schwarzkopff, Maike Hoffmann and Hanspeter Pircher
Inhibitory NK cell receptors are expressed in variable frequency by memory-phenotype T cells. In humans and mice, the killer cell lectin-like receptor G1 (KLRG1) is expressed by CD4 and CD8 T cells that exhibit a memory cell phenotype and by a large proportion of NK cells but not by monocytes, granulocytes or mast cells. Human KLRG1 is also found in a substantial subset of g/d T cells and, surprisingly, in a large proportion of phenotypically naive CD4 and CD8 T cells in umbilical cord blood.
The goal of this project is to determine the function of KLRG1 in vivo. For this purpose, transgenic mice expressing KLRG1 and KLRG1-deficient mice will be analyzed in different infection models.
References:
Schwartzkopff, S., Grundemann, C., Schweier, O., Rosshart, S., Karjalainen, K. E., Becker, K. F., and Pircher, H. 2007. Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans. J Immunol 179:1022
Gründemann C, M. Bauer, O. Schweier, N. von Oppen, U. Lässing, P. Saudan, K.F. Becker, K. Karp, T. Hanke, M. Bachmann and H. Pircher. 2006. Identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1 (KLRG1) J Immunol.176:1311.
Thimme, R, V. Appay, M. Koschella, E. Panther, E. Roth, A. Hislop, A. Rickinson, S. Rowland-Jones, H. Blum and H. Pircher. 2005. Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. J. Virology 79: 12112
Marcolino, I., G. K. Przybylski, M. Koschella, C. A. Schmidt, D. Voehringer, M. Schlesier, and H. Pircher. 2004. Frequent expression of the natural killer cell receptor KLRG1 in human cord blood T cells: correlation with replicative history. Eur J Immunol 34:2672
