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Prof. Dr. med. Georg Häcker

1. Originalarbeiten
2. Review articles/Book chapters

1. Originalarbeiten (seit 2004)

1. Vier, J., Gerhard, M., Fürmann, C., Wagner, H and Häcker, G. (2004) Acceleration of CD95-Induced Caspase-8-Activation by Uncoupling of Mitochondrial Oxidative Phosphorylation. Mol. Immunol, 40: 661-670.
2. Fischer, S., Harlander, T., Vier, J. and Häcker, G. (2004) Protection against CD95-induced apoptosis by chlamydial infection at a mitochondrial step. Infect. Immun,72:1107-15.
3. Kirschnek, S., Scheffel, J., Heinzmann, U. and Häcker, G. (2004) Necrosis-like cell death induced by bacteria in mouse macrophages. Eur. J. Immunol. 34:1461-71.
4. Schliep, S., Decker, T., Schneller, F., Wagner, H. and Häcker, G. (2004) Functional Evaluation of the Role of Inhibitor of Apoptosis Proteins in Chronic Lymphocytic Leukemia. Exp. Hematol. 32:556-562.
5. Von Bubnoff, D., Bausinger, H., Matz, H., Koch, S., Häcker, G., Takikawa, O., Bieber, T., Hanau, D. and de la Salle, H. (2004) Human epidermal langerhans cells express the immunoregulatory enzyme indoleamine 2,3-dioxygenase. J. Invest. Dermatol. 123:298-304.
6. Ruckdeschel, K., Pfaffinger, G., Haase, R., Sing, A., Weighard, H., Häcker, G., Holzmann, H. and Heesemann, J. (2004) Signaling of apoptosis through toll-like receptors critically involves Toll/IL-1 receptor domain containing adapter inducing IFN- but not myeloid differentiation factor 88 in bacteria-infected murine macrophages. J. Immunol., 173:3320-3328.
7. Kreuz, S., Siegmund, D., Rumpf, J.J., Samel, D., Leverkus, M., Janssen, O., Häcker, G., Dittrich-Breiholz, O., Kracht, M., Scheurich, P. and Wajant, H. (2004) NFB activation by Fas is mediated through FADD, Caspase-8 and RIP and is inhibited by FLIP. J Cell Biol., 166:369-80.
8. Fischer, S.F., Vier, J., Kirschnek, S., Klos, A., Hess, S., Ying, S. and Häcker, G. (2004) Chlamydia inhibit host cell apoptosis by degradation of pro-apoptotic BH3-only proteins. J Exp Med., 200:905-16.
9. Chaneva, S., Schneider, G., Siegmund, D., Wajant, H., Mages, J. and Häcker, G. (2004) Enhanced Basal AP-1-Activity and Deregulation of Numerous Genes in T Cells Transgenic for a Dominant Interfering Mutant of FADD/MORT1. Eur J Immunol., 34:3006-15.
10. Fischer, S.F., Rehm, M., Bauer, A., Höfling, F., Kirschnek, S., Rutz, M., Bauer, S., Wagner, H. and Häcker, G. (2005) Toll-like receptor 9-signaling can sensitise fibroblasts for apoptosis. Immunol. Letters, 97:115-122.
11. Kirschnek, S., Ying, S., Fischer, S.F., Häcker, H., Villunger, A., Hochrein, H. and Häcker, G. (2005) Phagocytosis-induced apoptosis in macrophages is mediated by up-regulation and activation of the BH3-only protein Bim. J Immunol., 174:671-679.
12. Ying, S., Seiffert, B.M., Häcker, G. and Fischer, S.F. Broad Degradation of Pro-Apoptotic BH3-only Proteins During Infection with Chlamydia trachomatis. Infect. Immun.,73:1399-1403.
13. Fischer, S.F., Ludwig, H., Holzapfel, J., Chen, L., Huang, D.C., Sutter, G. and Häcker, G. (2006) The early proteins E3L and F1L determine the molecular balance of apoptosis inhibition and induction by Modified Vaccinia virus Ankara. Cell Death and Differentiation, 13:109-118.
14. Fischer, S. F., Vier, J., Müller-Thomas, C. and Häcker, G. (2006) Molecular events in the induction of apoptosis by Legionella pneumophila in human cells. Microbe Infect, 8:662-669.
15. Häcker. H., Redecke, V., Blagoev, B., Kratchmarova, I., Wang, G., Kamps, M.P., Saha, S.K., Oganesyan, G., Raz, E., Wagner, H., Häcker, G., Mann, M., Cheng, G. and Karin, M. (2006) Specificity in TLR Signaling: Activation of the Interferon Response Depends on TRAF3. Nature, 439:204-207.
16. Verbeke, P., Stahl, L., Ying, S., Hansen, J., Häcker, G., Darville, T. and Ojcius, D. M. (2006) AKT Phosphorylation and Recruitment of BAD by the Chlamydia Vacuole Correlate With Infection-Induced Resistance to Apoptosis. PLoS Pathogens, e45.
17. Keller, P., Schaumburg, F., Fischer, S., Häcker, G., Groß, U., and Lüder, C.G. (2006) Direct inhibition of cytochrome c-induced caspase activation in vitro by Toxoplasma gondii reveals novel mechanisms of interference with host cell apoptosis. FEMS Microbiol Letters, 258(2):312-319.
18. You, H., Pellegrini, M., Tsuchihara, Y., Yamamoto, K., Häcker, G., Erlacher, M., Villunger, A. and Mak, T. W. (2006) FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med, 203(7):1657-1663.
19. Bauer, A., Villunger, A., Labi, V., Fischer, S.F., Erlacher, M., Strasser, A., Wagner, H., Schmid, R.M. and Häcker, G. (2006) The NF-B regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc Natl Acad Sci USA, 103:10979-84.
20. Ying, S., Fischer, S. F., Conte, D., Paschen, S. A., Ojcius, D. M. and Häcker, G. (2006) Characterization of Host Cell Death Induced by Chlamydia trachomatis. Infect Immun, 74:6057-66
21. Häcker, G., Suttner, K., Harada, H. and Kirschnek, S. (2006) TLR-dependent Bim phosphorylation in macrophages is mediated by ERK and is connected to proteasomal degradation of the protein. Int Immunol, 18:1749-57.
22. Erlacher, M., Labi, V., Manzl, C., Böck, G., Tzankov, A., Häcker, G., Michalak, E., Strasser, A. and Villunger, A. (2006) Bim is the rate-limiting BH3-only protein mediating cell death during lymphocyte development but cooperates with PUMA in cytokine-deprivation and stress-induced apoptosis. J Exp Med, 203:2939-51.
23. Zantl, N., Weirich, G., Hilpert, C., Seiffert, B., Fischer, S.F., Gillissen, B., Daniel, P. T. and Häcker, G. Low expression of the BH3-only protein Bim is a determinant of apoptosis resistance in renal cell carcinoma. Oncogene, May 2007 (Epub ahead of print).
24. Weber, A., Paschen, S. A., Heger, K., Wilfling, F., Frankenberg, T., Bauerschmitt, H., Seiffert, B. M., Kirschnek, S., Wagner, H. and Häcker, G. BimS Induced Apoptosis Requires Mitochondrial Localization but not Interaction with Anti-Apoptotic Bcl-2 Proteins. J Cell Biol. 177(4):625-36 (2007).
25. Bauer, A., Kirschnek, S. and Häcker, G. (2007) Inhibition of apoptosis can be accompanied by increased Bim levels in T lymphocytes and neutrophil granulocytes (Letter) Cell Death and Differentiation, 14(9):1714-6.
26. Ying, S. and Häcker, G. (2007) Apoptosis induced by direct triggering of mitochondrial apoptosis proceeds in the near-absence of some apoptotic markers. Apoptosis, 12(11):2003-11.
27. Fuchs, M., Hermannstädter, C., Haller, F., Häcker, G., Hutzler, P., Höfler, H. and Luber, B. (2008) Caspase-mediated cleavage of tumor-derived mutant E-cadherin during cisplatin-induced apoptosis. Exp Cell Res, 314(1):153-63
28. Ying, S., Christian, J. G., Paschen, S. A. and Häcker, G. (2008) Chlamydia trachomatis can protect host cells against apoptosis in the absence of cellular Inhibitor of Apoptosis Proteins and Mcl-1. Microbes and Infection, 10(1):97-101.
29. Frankenberg, T., Kirschnek, S. and Häcker, G. (2008) Phagocytosis-induced apoptosis of macrophages is linked to uptake, killing and degradation of bacteria. European Journal of Immunology, 38(1):204-15.
30. Rangelova, S., Kirschnek, S., Strasser, A. and Häcker, G. (2008) FADD and the NF-B Member Bcl-3 Regulate Complementary Pathways to T Cell Survival and Proliferation. Immunology 125(4):549-57.
31. Paschen, S., Christian, J. G., Vier, J., Schmidt, F., Walch, A., Ojcius, D. M. and Häcker. G. (2008) Cytopathicity of Chlamydia infection can be largely reproduced by expressing a single chlamydial gene, Chlamydial Protease-like Activity Factor. J Cell Biol, 182(1):117-27
32. Ying S, Pettengill M, Latham ER, Walch A, Ojcius DM, Häcker G. (2008) Premature apoptosis of Chlamydia-infected cells disrupts chlamydial development. J Infect Dis; 198(10):1536-44
33. Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya SS, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S, Meyers R, Häcker G, Neuenhahn M, Busch D, Ruland J, Rothenfusser S, Prinz M, Hornung V, Endres S, Tüting T, Hartmann G. (2008) 5’-triphosphate-siRNA: turning gene silencing and Rig-1 activation against melanoma. Nat Med;14(11):1256-63
34. Weber, A., Kirejczyk, Z., Potthoff, S., Ploner, C. and Häcker, G. (2009) Endogenous Noxa determines the strong pro-apoptotic synergism of the BH3-mimetic ABT-737 with chemotherapeutic agents in human melanoma cells. Transl. Oncology, 2(2):73-83.
35. Lohmann, C., Muschweckh, A., Kirschnek, S., Jennen, L., Wagner, H. and Häcker, G.(2009) Induction of tumor cell apoptosis or necrosis by conditional expression of cell death proteins: analysis of cell death pathways and in vitro immune stimulatory potential. J Immunol., 182(8):4538-46.
36. Koedel, U., Frankenberg, T., Kirschnek, S., Obermaier, B., Häcker, H., Paul., R. and Häcker, G. (2009) Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis. PLoS Pathogens, May;5(5):e1000461.
37. Brenk, M, Scheler, M., Koch, S., Neumann, J., Takikawa, O., Häcker, G., Bieber, T and von Bubnoff, D. (2009) Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+Foxp3+ T regulatory cells J Immunol., 183(1):145-54
38. Besch, R., Poeck, H., Hohenauer, T., Senft, D, Häcker, G., Berking, C., Hornung, V., Endres, S., Ruzicka, T., Rothenfusser, S and Hartmann, G.Proapoptotic signalling by RIG-I and MDA-5 results in tumor-specific apoptosis independent of type I interferons in melanoma. J Clin Invest., in press

2. Review articles/Book chapters

1. Häcker, G. (2004). Fas – activation, development and homeostasis of T cells. In Fas Signaling (edited by Harald Wajant), Eurekah Press.
2. Häcker, G., Kirschnek, S. and Fischer, S.F. (2006) Apoptosis in infectious disease: how bacteria interfere with the apoptotic apparatus. Medical Microbiology and Immunology 195:11-19.
3. Häcker, G., Bauer, A. and Villunger, A. (2006) Apoptosis in Activated T Cells – What Are the Triggers, and What the Signal Transducers? Cell Cycle, 5:2421-4.
4. Ying, S., Pettengill, M., Ojcius, D. M. and Häcker, G. (2007) Host-Cell Survival and Death During Chlamydia Infection. Current Immunology Reviews, 3(1):31-40.
5. Häcker, G. and Weber, A. (2007) BH3-only Proteins Trigger Cytochrome c-Release, But How? Arch Biochem Biophys, 462(2):150-5.
6. Häcker, G. and Paschen, S. A. (2007) Therapeutic targets in the mitochondrial pathway. Expert Opinion in Drug Development, 11(4):515-26.
7. Paschen, S., Weber, A. and Häcker, G (2007) Mitochondrial protein import: a matter of death? Cell Cycle, 6(20):2434-9.
8. Häcker, G. Microbial inhibitors of apoptosis. In Encyclopaedia of Life Sciences. In press.

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