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Original Papers
Arampatzidou, M., Mayer, K., Iolyeva, M.E., Asrat, S.G., Ravichandran, M., Gunther, T., Schule, R., Reinheckel, T., and Brix, K. (2011). Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP. Biol Chem 392, 983-993.	PDF
Bissinger, E.M., Heinke, R., Spannhoff, A., Eberlin, A., Metzger, E., Cura, V., Hassenboehler, P., Cavarelli, J., Schule, R., Bedford, M.T., et al. (2011). Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem 19, 3717-3731.
Gullotti, L., Czerwitzki, J., Kirfel, J., Propping, P., Rahner, N., Steinke, V., Kahl, P., Engel, C., Schule, R., Buettner, R., et al. (2011). FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer. Lab Invest.	PDF
Hauser, A.T., Bissinger, E.M., Metzger, E., Repenning, A., Bauer, U.M., Mai, A., Schule, R., and Jung, M. (2011). Screening Assays for Epigenetic Targets Using Native Histones as Substrates. J Biomol Screen.	PDF
Rafael, M.S., Laize, V., Bensimon-Brito, A., Leite, R.B., Schule, R., and Cancela, M.L. (2011). Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata. Cell Mol Life Sci.	PDF
Schildhaus, H.U., Riegel, R., Hartmann, W., Steiner, S., Wardelmann, E., Merkelbach-Bruse, S., Tanaka, S., Sonobe, H., Schule, R., Buettner, R., et al. (2011). Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors. Hum Pathol 42, 1667-1675.	PDF
Nair, S S, Nair, B C, Cortez, V, Chakravarty, D, Metzger, E, Schüle, R, Brann, D W, Tekmal, R R, Vadlamudi, R K (2010). PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity. EMBO reports 11, 438-44.	PDF
Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N, Müller JM, Greschik H, Kirfel J, Ji S, Kunowska N, Beisenherz-Huss C, Günther T, Buettner R, Schüle R. (2010). Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature 464, 792-6.	PDF
Heyne K, Willnecker V, Schneider J, Conrad M, Raulf N, Schüle R, Roemer K (2010). NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle. Nucleic Acids Res.	PDF
Lim S, Janzer A, Becker A, Zimmer A, Schüle R, Buettner R, Kirfel J (2010). Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis 31, 512-20.	PDF
Schulte, EC, Slawik, H, Schüle, R, Gunther, T, Hüll, M (2009). Alterations in excitotoxicity and prostaglandin metabolism in a transgenic mouse model of Alzheimer's disease. Neurochem Int. 55, 689-96.	PDF
Schulte, JH, Lim, S, Schramm, A, Friedrichs, N, Koster, J, Versteeg, R, Ora, I, Pajtler, K, Klein-Hitpass, L, Kuhfittig-Kulle, S, Metzger, E, Schüle, R, Eggert, A, Buettner, R, Kirfel, J. (2009). Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. Cancer Res. 69, 2065-71.	PDF
Zhao Y, Lang G, Ito S, Bonnet J, Metzger E, Sawatsubashi S, Suzuki E, Le Guezennec X, Stunnenberg HG, Krasnov A, Georgieva SG, Schüle R, Takeyama K, Kato S, Tora L, Devys D. (2008). A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Molecular Cell. 29, 92-101.	PDF
Metzger E, Yin N, Wissmann M, Kunowska N, Fischer K, Friedrichs N, Patnaik D, Higgins JM, Potier N, Scheidtmann KH, Buettner R, Schüle R. (2008). Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nat Cell Biol. 10, 53-60.	PDF
Spira D, Stypmann J, Tobin DJ, Petermann I, Mayer C, Haggemann S, Vasiljeva O, Gunther T, Schule R, Peters C, Reinheckel T. (2007). Cell type-specific functions of the lysosomal protease cathepsin L in the heart. J Biol Chem. J Biol Chem. 282, 37045-37052.	PDF
Spannhoff A, Machmur R, Heinke R, Trojer P, Bauer I, Brosch G, Schule R, Hanefeld W, Sippl W, Jung M. (2007). A novel arginine methyltransferase inhibitor with cellular activity. Bioorg Med Chem Lett. 17, 4150-3.	PDF
Spannhoff A, Heinke R, Bauer I, Trojer P, Metzger E, Gust R, Schule R, Brosch G, Sippl W, Jung M. (2007). Target-based approach to inhibitors of histone arginine methyltransferases. Bioorg J Med Chem. 50, 2319-25.	PDF
Nair SS, Guo Z, Mueller JM, Koochekpour S, Qiu Y, Tekmal RR, Schule R, Kung HJ, Kumar R, Vadlamudi RK. (2007). Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein. Mol Endocrinol. 21, 613-24.	PDF
Wixler V, Hirner S, Muller JM, Gullotti L, Will C, Kirfel J, Gunther T, Schneider H, Bosserhoff A, Schorle H, Park J, Schule R, Buettner R. (2007). Deficiency in the LIM-only protein Fhl2 impairs skin wound healing. J Cell Biol. 177, 163-72.	PDF
Wissmann M, Yin N, Mueller JM, Greschik H, Fodor BD, Jenuwein T, Vogler C, Schneider R, Guenther T, Buettner R, Metzger E, Schuele R (2007). Co-operative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol. 9, 347-353.	PDF
Nair SS, Guo Z, Müller JM, Koochekapour S, Qiu Y, Tekmal RR, Schüle R, Kung HJ, Kumar R, Vadlamundi RK. (2007) PELP1/MNAR enhances androgen receptor functions through LIM-only coactivator FHL2. Mol Endocrinol. 21, 613-624.	PDF
Kahl P, Gullotti L, Heukamp LC, Wolf S, Friedrichs N, Vorreuther R, Solleder G, Bastian PJ, Ellinger J, Metzger E, Schuele R, Buettner R (2006). Androgen Receptor Coactivators Lysine-Specific Histone Demethylase 1 and Four and a Half LIM Domain Protein 2 Predict Risk of Prostate Cancer Recurrence. Cancer Res. 66, 11341-11347.	PDF
Bagheri-Fam S, Barrionuevo F, Dohrmann U, Gunther T, Schule R, Kemler R, Mallo M, Kanzler B, Scherer G. (2006). Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern. Dev. Biol. 291, 382-97.	PDF
Gabriel B, Fischer DC, Orlowska-Volk M, zur Hausen A, Schuele R, Muller JM and Hasenburg A (2006). Expression of the transcriptional coregulator FHL2 in human breast cancer: a clinicopathologic study. J. Soc. Gynecol. Investig. 13, 69-75.	PDF
Hublitz P, Kunowska N, Mayer UP, Muller JM, Heyne K, Yin N, Fritzsche C,Poli C, Miguet L, Schupp IW, van Grunsven LA, Potiers N, van Dorsselaer A,Metzger E, Roemer K, Schuele, R. (2005). NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Genes Dev. 19, 2912-24.	PDF
Metzger E, Wissmann M, Yin N, Muller JM, Schneider R, Peters AH, Gunther T, Buettner R, Schuele, R. (2005). LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription Nature. 437, 436-439.	PDF
Gunther T, Poli C, Muller JM, Catala-Lehnen P, Schinke T, Yin N, Vomstein S, Amling M, Schuele, R. (2005). Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts. EMBO J. 24, 3049-56.	PDF
Bai, S., Kitaura, H., Zhao, H., Chen, J., Muller, J.M., Schuele, R., Darnay, B., Novack, D.V., Ross, F.P. and Teitelbaum. S.L. (2005). FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. J. Clin. Invest. 115, 2742-2751.	PDF
Purcell, N.H., Darwis, D., Bueno, O.F., Muller, J.M., Schuele, R. and Molkentin, J.D. (2004). Extracellular signal-regulated kinase 2 (ERK2) interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes. Mol. Cell. Biol. 24, 1081-1095.	PDF
Gabriel B, Mildenberger S, Weisser CW, Metzger E, Gitsch G, Schuele, R , Mueller JM (2004). Focal adhesion kinase interacts with the transcriptional coactivator FHL2 and both are overexpressed in epithelial ovarian cancer. Anticancer Res. 24, 921-7.	PDF
Samson, T., Smyth, N., Janetzky, S., Wendler, O., Mueller, J.M., Schuele, R., von der Mark, H., von der Mark, K. and Wixler, V. (2004). The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor. J. Biol. Chem. 279, 28641-28652.	PDF
Hagemann, S., Guenther, T., Dennemärker, J., Lohmueller, T., Brömme, D., Schuele, R., Peters, C. and Reinheckel,T. (2004). The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles. Eur. J. Cell. Biol. 83, 775-780.	PDF
Oehler, MK., Greschik, H., Fischer, DC., Tong, X., Schuele, R. and Kieback, DG. (2004). Functional characterization of somatic point mutations of the human estrogen receptor alpha in adenomyosis uteri. Mol. Hum. Reprod. 12, 853-860.	PDF
Philippar U, Schratt G, Dieterich C, Muller JM, Galgoczy P, Engel FB, Keating MT, Gertler F, Schuele, R., Vingron M, Nordheim A. (2004). The SRF Target Gene Fhl2 Antagonizes RhoA/MAL-Dependent Activation of SRF. Mol. Cell. 16, 867-80.	PDF
Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schule R. (2003). All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Nat. Struct. Biol. 10, 820-825.	PDF
Metzger E, Muller JM, Ferrari S, Buettner R, Schuele, R. (2003). A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer. EMBO J. 15, 270-280.	PDF
Du, X., Hublitz, P., Guenther, T., Wilhelm, D., Englert, C. and Schuele, R. (2002). The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation. Biochimica et Biophysica Acta. 1577, 93-101.	PDF
Conceicao, N., Henriques, N.M. , Marc C.P., Ohresser, M.C.P., Hublitz, P., Schuele, R. and Cancela, L.M. (2002). Molecular cloning of the MGP gene from Xenopus laevis: functional analysis of the promoter identifies a calcium sensitive region required for basal activity. Eur. J. Biochem. 269, 1947-1956.	PDF
Mueller, J.M., Metzger, E., Greschik, H., Bosserhoff, A-K., Mercep, L., Buettner, R. and Schuele, R. (2002). The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus. EMBO J. 21, 736-748.	PDF
Stehlin C, Wurtz JM, Steinmetz A, Greiner E, Schuele R., Moras D, Renaud JP. (2001). X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation. EMBO J. 20, 5822-5831.	PDF
Greiner, E., Kirfel, J., Greschik, H., Huang, D., Becker, P., Kapfhammer, J.P. and Schuele, R. (2000). Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor. Proc. Natl. Acad. Sci. USA 97, 7160-7165.	PDF
Mueller, J.M., Isele, U., Metzger, E., Rempel, A., Moser, M., Pscherer, A., Breyer, T., Holubarsch, C., Buettner, R. and Schuele, R. (2000) FHL2, a novel tissue-specific coactivator of the androgen receptor. EMBO J. 19, 359-369.	PDF
Dörflinger, U., Pscherer, A., Moser, M., Ruemmele, P., Schuele, R. and Buettner, R. (1999) Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain. Mol. Cell. Biol. 19, 3736-3747.	PDF
Greschik, H., Wurtz, J.-M., Hublitz, P., Köhler, F., Moras, D. and Schuele, R. (1999) Characterization of the DNA-binding and dimerization properties of the nuclear orphan receptor GCNF. Mol. Cell. Biol. 19, 690-703.	PDF
Pfitzner, E., Kirfel, J., Becker, P., Rolke, A. and Schuele, R. (1998) Physical interaction between retinoic acid receptor and the oncoprotein Myb inbhibits retinoic acid dependent transactivation. Proc. Natl. Acad. Sci. USA 95, 5539-5544.	PDF
Kirfel, J., Kelter, M., Cancela, L.M., Price, P. and Schuele, R. (1997) Identification of a novel negative retinoic acid receptor response element in the promotor of the human matrix Gla protein gene. Proc. Natl. Acad. Sci. USA 94, 2227-2232.	PDF
Pscherer, A., Dörflinger, U., Kirfel, J., Gawlas, K., Rueschoff, J., Buettner, R. and Schuele, R. (1996) The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene. EMBO J. 15, 6680-6690.
Greiner, E., Kirfel, J., Dörflinger, U., Greschik, H., Becker, P., Mercep, A. and Schuele, R. (1996) Functional analysis of retinoid Z receptor b, a brain-specific nuclear orphan receptor. Proc. Natl. Acad. Sci. USA 93, 10105-10110.	PDF
Pfitzner, E., Becker, P., Rolke, A. and Schuele, R. (1995) Functional antagonism between the retinoic acid receptor and the viral transactivator BZLF1 is mediated by protein-protein interactions. Proc. Natl. Acad. Sci. USA 92, 12265-12269.	PDF
Moser, M., Imhof, A., Pscherer, A., Bauer, R., Amselgruber, W., Sinowatz, F., Hofstädter, F., Schuele, R. and Buettner, R. (1995) Cloning and characterization of a second AP-2 transcription factor: AP-2b. Development 121, 2779-2788.	PDF
Rohrer, R., Raulf, F., Bruns, Ch., Hofstädter, F, Buettner, R. and Schuele, R. (1993) Cloning and characterization of a fourth human somatostatin receptor. Proc. Natl. Acad. Sci. USA 90, 4196-4200.	PDF
Schuele, R., Pundi, R., Yang, N., Kliewer, S., Bolado, J., Verma, I.M. and Evans, R.M. (1991) Retinoic acid is a negative regulator of AP-1 responsive genes. Proc. Natl. Acad. Sci. USA 88, 6092-6096.
Yang, N., Schuele, R., Mangelsdorf, D.J. and Evans, R.M. (1991) Characterization of DNA binding and retinoic acid binding properties of retinoic acid receptor. Proc. Natl. Acad. Sci. USA 88, 3559-3563.
Schuele, R., Pundi, R., Kliewer, S., Ransone, L.J., Bolado, J., Yang, N., Verma, I.M. and Evans, R.M. (1990) Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62, 1217-1226.
Schuele, R., Umesono, K., Mangelsdorf, D., Bolado, J., Pike, W.J. and Evans, R.M. (1990). Jun/Fos and receptors for vitamin A and D recognize a common response element in the human osteocalcin gene. Cell 61, 497-504.
Schuele, R. (1988) Hormonal regulation of the rat tryptophan oxygenase gene. Intemann Press, Muenchen.
Schuele, R., Muller, M., Kaltschmidt, Ch. and Renkawitz, R. (1988) Many transcription factors interact synergistically with steroid receptors. Science 242, 1418-1420.
Schuele, R., Muller, M., Otzuka-Murakami, H. and Renkawitz, R. (1988) Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor. Nature 322, 87-90.
Danesch, U., Gloss, B., Schmid, W., Schuetz, G., Schuele, R. and Renkawitz, R. (1987) Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid responsive elements. EMBO J. 6, 625-630.

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