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MR Phase Contrast and Susceptibility Weighted Imaging of the Rodent Brain
We are currently working on developing methods to enhance contrast between brain tissue structures by exploiting the phase MR signal at high-field strength. Magnetic heterogeneity of brain tissue is caused by the venous vascular system (paramagnetic blood deoxyhemoglobin), by different tissue iron concentrations and tissue myelin content. These heterogeneities are the origin of phase contrast and susceptibility weighted imaging (SWI) since they induce an offset in the resonance frequency that can be detected in the signal phase.
In this study SWI was employed to improve contrast between several regions of different magnetic susceptibilities by combining magnitude and phase information. Phase and SWI images revealed, often more clearly than the corresponding magnitude images, the laminar structure of the rat cortex ((a) - red arrow), the hippocampus substructures like the pyramidal cell layer (in CA1 to CA3) and dentate gyrus (DG) (b). Moreover, this method gives a comprehensive insight of the venous brain vascular system (c).
