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Development of MR Micro Coils
Dr. Nicoleta Baxan
cand. phys. Katharina Göbel
Development of single and phased array MR microcoils
The focus on MR analysis of mass limited and volume limited samples has led to the downscaling of MR receiver coils, largely enhancing the local signal-to-noise ratio (SNR) but inherently reducing the field of view. Our group is currently developing various types of microcoils (single and arranged in a phased array configuration) in close collaboration with the IMTEK Institute in Freiburg (
http://www.imtek.de/ ).
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Single microcoils |
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References: Badilita V et al, Lab Chip. 2010 Jun 7;10(11):1387-90. Mohammadzadeh M, Baxan N et al, J Magn Reson. 2011;208(1):20-6.
Phased array of microcoils
A classical way to enlarge the FOV in the MR experiment is to arrange multiple receiver coils in a phased array geometry, i.e., replacing a large single coil with multiple smaller coils, sharing an overlap. The here presented phased array of microcoils (d) was fabricated using state of the art wirebonding technology in conjunction with MEMS fabrication techniques in a fully MEMS-compatible process. Seven hexagonally wirebonded microcoils (e) made of 25 μm diameter electrically insulated gold wire, all embedded in SU-8 are forming the array (d, e).
(a) MR image of fish oocytes enabling delineation of polarized nucleus (N) and the animal (AP) and vegetal (VP) poles as shown in the magnified view displayed in (b). The B0 variation is relatively homogenous in the central part of the coil (framed area in Fig. c) with frequency shifts not exceeding 100 Hz
References: Gruschke O, Baxan N et al, Lab on a chip phased-array MR multi-platform analysis system. Lab Chip 2012
