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The main focus of the Advanced Molecular Imaging Research Center is multimodal imaging for pre-clinical and translational research. Our work is dedicated to the fusion of cellular research and clinical projects in development and implementation of novel and advanced techniques for small animal imaging – in particular in vivo magnetic resonance imaging (MRI), small animal PET, CT and optical imaging. Further goals are to provide cutting edge technology and research tools in cooperation with our partners in the University of Freiburg.

Group members

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Current highlights

In Vivo DT-MRI and Fiber Tracking of the Mouse Brain	Method Development for High field MRI	Multimodal Imaging of dendritic cells using - MRI based tracking after cell transplantation

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Projects

projects in execution

• Renal-Cyst-model
• DWI in Ewingsarcoma
• Targeted Contrast Agents
• Phase Contrast and Susceptibility Weighted Imaging in the Rodent Brain
• Manganese Enhanced Imaging
• 1H and X-nuclei specroscopy
• 19F Imaging
• Hyperpolarized 13C MRI and MRS
• Vessel Size Imaging (VSI)
• Method Development
• Development of micro MR coils (EU-NEST project)
• MR Microscopy (EU-NEST project)

completed projects

• Funktionalized nanoparticles for molecular imaging (Funk MoB)
• Funktionalized nanoparticles for plaque imaging (NanoAG)

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Publications

2011

• Ta H. T, Prabhu S, Leitner E, Jia F, von Elverfeldt D, Jackson K E, Heidt T, Nair A K, Pearce H, von Zur Muhlen C, Wang X, Peter K, Hagemeyer C E.
  Enzymatic single-chain antibody tagging: a universal approach to targeted molecular imaging and cell homing in cardiovascular disease
  Circ Res 2011 Aug; 109(4): 365-373

• Weber H, Baxan N, Paul D, Maclaren J, Schmidig D, Mohammadzadeh M, Hennig J, von Elverfeldt D.
  Microcoil-based MRI: Feasibility study and application on cell cultures
  Magn Reson Mater Phy 2011 Jun; 24(3): 137-145

• Hadjidemetriou S, Reichardt W, Hennig J, Buechert M, von Elverfeldt D.
  Analysis of MRI Data Monitoring the Preclinical Treatment of Polycystic Kidney Disease in a Mouse Model
  Magn Reson Mater Phy 2011 Apr; 24(2):109-119

• Weigel J K, Steinmann D, Emerich P, Stahl C A, von Elverfeldt D, Guttmann J.
  High-resolution three-dimensional 19F-magnetic resonance imaging of rat lung in situ: evaluation of airway strain in the perfluorocarbon-filled lung
  Physiol Meas 2011 Feb; 32(2):251-262

• Merz M, Komljenovic D, Zwick S, Semmler W, Bauerle T.
  Sorafenib tosylate and paclitaxel induce anti-angiogenic, anti-tumour and anti-resorptive effects in experimental breast cancer bone metastases
  Eur J Cancer 2011 Jan; 47(2):277-286

• Mohmmadzadeh M, Baxan N, Badilita V, Kratt K, Weber H, Korvink J G, Wallrabe U, Hennig J, von Elverfeldt D.
  Characterization of a 3D MEMS fabricated micro-solenoid at 9.4T
  J Magn Reson 2011 Jan; 208(1):20-26

• Reisert M, Mader I, Anastasopoulos C, Weigel M, Schnell S, Kiselev VG.
  Global fiber reconstruction becomes practical
  NeuroImage 2011 Jan; 54(2):955-962

• Torio-Padron N, Paul D, von Elverfeldt D, Stark G B, Huotari A M.
  Resorption rate assessment of adipose tissue-engineered constructs by intravital magnetic resonance imaging
  J Plast Reconstr Aesthet Surg 2011 Jan; 64(1):117-122

2010

• von zur Muhlen C, Fink A, Salaklang J, Paul D, Neudorfer I, Berti V, Merkle A, Peter K, Bode C, von Elverfeldt D.
  Imaging monocytes with iron oxide nanoparticles targeted towards the monocyte integrin MAC-1 does not result in improved atherosclerotic plaque detection by in vivo MRI.
  Contrast Media and Molecular Imaging 2010 Sep/Okt; 5(5):268-275

• Brix G, Zwick S, Griebel J, Fink C, and Kiessling F.
  Estimation of Tissue Perfusion by Dynamic Contrast-Enhanced Imaging: Simulation-based Evaluation of the Steepest-Slope Method.
  European Radiology in press 2010 Sep.; 20(9):2166-2175

• Harsan L, Paul D, Schnell S, Kreher B, Hennig J, Staiger J, von Elverfeldt D.
  In vivo Diffusion Tensor Magnetif Resonance Imaging and Fiber Tracking of the mouse brain.
  NMR in Biomedicine 2010 Aug; 23(7):884-896

• Palmowski M, Schifferdecker I, Zwick S, Macher-Goeppinger S, Laue H, Haferkamp A, Kauczor H U, Kiessling F, Hallscheidt P.
  Tumor perfusion assessed by dynamic contrast-enhanced MRI correlates to the grading of renal cell carcinoma: initial results
  Eur J Radiol 2010 Jun; 74(3):e176-80-90.

• Badilita V, Kratt K, Baxan N, Mohmmadzadeh M, Burger T, Weber H, Elverfeldt D, Hennig J, Korvink JG, Wallrabe U.
  On-chip three dimensional microcoils for MRI at microscale.
  Lab Chip 2010 Jun; 10(11):1387-90.

• Bauerle T, Merz M, Komljenovic D, Zwick S, Semmler W.
  Drug-induced vessel remodeling in bone metastases as assessed by dynamic contrast enhanced magnetic resonance imaging and vessel size imaging: a longitudinal in vivo study.
  Clin Cancer Res 2010 Jun; 16(12):3215-3225.

• Perman W, Battacharya P, Leupold J, Lin A, Harris K, Norton V, Hoevener J, Ross B.
  Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C labeled compounds using multiple echo 3D bSSFP
  Magnetic Resonance Imaging 2010 May; 28(4):459-465

• Gierthmuehlen M, Freiman T, von Elverfeldt D, and Kaminsky J.
  Microsurgical approach to the spinal canal in rats.
  J Neurosci Methods 2010 May; 188(2):295-301.

• Kuntz J, Dinkel J, Zwick S, Bauerle T, Grasruck M, Kiessling F, Gupta R, Semmler W, Bartling SH.
  Fully automated intrinsic respiratory and cardiac gating for small animal CT.
  Physics in medicine and biology 2010 Apr.; 55(7):2069-2085.

• Lederle W, Linde N, Heusel J, Bzyl J, Woenne EC, Zwick S, Skobe M, Kiessling F, Fusenig NE, Mueller MM.
  Platelet-derived growth factor-B normalizes micromorphology and vessel function in vascular endothelial growth factor-A-induced squamous cell carcinomas.
  The American journal of pathology 2010 Feb.; 176(2):981-994.

• Torio-Padron N, Huotari A, Paul D, von Elverfeldt D, Borges J, Stark B.
  Resorption Rate Adssessment of Adipose Tissue Engineered Constructs by Intravital Magnetic Resonance Imaging.
  Tissue Engineering 2010 Jan; 64(1):117-122

• Weber H, Paul D, von Elverfeldt D, Hennig J, Zaitsev M
  Extended Multi-Flip-Angle approach: a 3D mapping method for inhomogeneous B1-fields.
  Concepts in Magnetic Resonance 2010; 37B(4):203-214

2009

• Paul D, Zaitsev M, Harsan L, Kurutsch A, Splitthoff DN, Hennel F, Choli M, von Elverfeldt D.
  Implementation and Application of PSF-Based EPI Distortion Correction to High Field Animal Imaging.
  Int J Biomed Imaging. 2009:946271. Epub 2009 Dec 31.PMID: 20069119

• Leupold J, Mansson S, Stefan Petersson J, Hennig J, Wieben O.
  Fast multiecho balanced SSFP metabolite mapping of (1)H and hyperpolarized (13)C compounds.
  Magn Reson Mater Phy 2009;22:251-256

• Hadjidemetriou, S., Reichardt, W., Buechert, M., Hennig, J., von Elverfeldt, D.
  Analysis of MR images of mice in preclinical treatment monitoring of polycystic kidney disease.
  Proc. of the 12th International Conference on MICCAI. LNCS. Sep 2009

• Paul D, Zaitsev M.
  Improved SNR in linear reordered 2D bSSFP imaging using variable flip angles.
  Magn Reson Imaging 2009;27(7):933-941

• Reichardt W, Juettner E, Uhl M, von Elverfeldt D, Kontny U. Diffusion weighted Imaging as Predictor of Therapy Response in an Animal Model of Ewing’s-Sarcoma.
  Magn Reson Mater Phy 2009;22:143-149

• Hagemeyer CE, von Zur Muhlen C, von Elverfeldt D, Peter K.
  Single-chain antibodies as diagnostic tools and therapeutic agents.
  Thrombosis and haemostasis 2009;101(6):1012-1019.

• Paul D, Sommer G, Leupold J, Hentschel M, Baumann T, Ludwig U.
  Chemical shift selective fat imaging using transition into driven equilibrium balanced steady-state free precession for quantification of adipose tissue.
  Journal of computer assisted tomography 2009;33(3):475-480.

• Reichardt W, Daniel Romaker, Anne Becker, Martin Buechert, von Elverfeldt D
  Monitoring Kidney and Renal Cyst Volumes applying MR approaches on a Rapamycin treated Mouse Model of ADPKD.
  Magn Reson Mater Phy 2009 June; 22(3): 143-9. Epub 2008 Dec 24

2008

• Reichardt W, Dürr C, von Elverfeldt D, Jüttner E, Gerlach UV, Yamada M, Smith B, Negrin RS, Zeiser R.
  Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation.
  J Immunol. 2008 Oct 1;181(7):4770-9.

• Schurigt U, Sevenich L, Vannier C, Gajda M, Schwinde A, Werner F, Stahl A, von Elverfeldt D, Becker AK, Bogyo M, Peters C, Reinheckel T
  Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MTV-PyMT-transgenic mouse model.
  Biological Chemistry, 2008 Aug; 389: 1067-1074
  

• Shih Y-Y, Büchert M, Chung H-W, Hennig J, von Elverfeldt D.
  Vitamin C estimation with standard 1H spectroscopy using a clinical 3T MR-system: Detectability and Reliability within the human brain.
  Journal of Magnetic Resonance Imaging 2008 Aug;28(2):351-8
  

• von zur Muhlen C*, von Elverfeldt D*, Moeller J, Chodhury R, Paul D, Hagemeyer C, Becker A-K, Neudorfer I, Schwarz M, Bode C, Peter K.
  A magnetic resonance imaging contrast agent targeted towards activated platelets allows in vivo detection of thrombosis and monitoring of thrombolysis.
  Circulation 2008 Jul 15;118(3):258-67
  

• Werner S, Mendoza A, Hilger R, Erlacher M, Reichardt W, Lissat A, Konanz C, Uhl M, Niemeyeer C, Khanna C, Kontny U.
  Preclinical studies of treosulfan demonstrate potent activity in Ewing's sarcoma.
  Cancer Chemotherapy and Pharmacology 2008 Jun;62(1):19-31.

• Fritsch A, Loekermann S, Kern JS, Braun A, Bösl MR, Bley T, Schumann H, von Elverfeldt D, Paul D, Erlacher M, von Rautenfeld DB, Hausser I, Fässler R, Bruckner-Tuderman L.
  A hypomorphic mouse model for dystrophic epidermolysis bullosa reveals disease mechanisms and responds to fibroblast therapy.
  Journal of Clinical Investigation 2008 May;118(5):1669-79
  

• Zhong K, Leupold J, v. Elverfeldt D, Speck O
  The Molecular Basis for Gray and White Matter Contrast in Phase Imaging.
  Neuroimage 2008 May;40(4):1561-6
  

• von zur Muhlen C*, von Elverfeldt D*,Choudhury RP, Ender J, Ahrens I, Schwarz M, Hennig J, Bode C, Peter K.,
  A functionaliszed magnetic resonance contrast agent selectively binds to glycoprotein iib/iiia on activated human platelets under flow conditions and is detectable at clinically relevant field strengths.
  Molecular Imaging 2008 Mar-Apr;7(2):59-67
  

• Spiegelhalder K, Feige B, Paul D, Riemann D, van Elst LT, Seifritz E, Hennig J, Hornyak M.
  Cerebral correlates of muscle tone fluctuations in restless legs syndrome: a pilot study with combined functional magnetic resonance imaging and anterior tibial muscle electromyography.
  Sleep Med. 2008 Jan;9(2):177-183.

• Stalder AF, von Elverfeldt D, Paul D, Hennig J, Markl M.
  Variable Echo Time Imaging and Signal Characteristics of 1-M Gadobutrol Contrast Agent at 1.5 and 3T.
  Magn Reson Med 2008 Jan; 59(1):113-123
  

2007

• Paul D, Frydrychowicz A, Walcher J, Fautz HP, Hennig J, Langer M, Schäfer O.
  Can Homogeneous Preparation Encoding (HoPE) Help Reduce Scan Time in Abdominal MRI? A Clinical Evaluation.
  J Magn Reson Imag 26:442-447.
  

• Hentschel M, Paul D, Moser E, Brink I.
  Moeglichkeiten und Grenzen der modernen Schnittbildverfahren (CT, MRT, PET) in der Molekularen Bildgebung.
  Der Nuklearmediziner 30:31-41.
  

• von Elverfeldt D, Niekisch M, Quaschning T, El Saman A, Kirste G, Kraemer-Guth A, Hennig J.
  Kinetics of PME/Pi in Pig Kidneys during Cold Ischemia
  NMR in Biomedicine 2007 Nov;20(7):652-657
  

• von zur Muehlen C, von Elverfeldt D, Bassler N, Neudorfer I, Steitz B, Petri-Fink A, Hofmann H, Bode C, Peter K.
  Superparamagnetic Iron Oxide Binding and Uptake as Imaged by Magnetic Resonance is Mediated by the Integrin Receptor Mac-1 (CD11b/CD18): Implications on Imaging of Atherosclerotic Plaques
  Atherosclerosis 2007 Jul;193(1):102-11.

2006

• Uhl M., Saueressig U., Kontny U, Reichardt W., V. Buiren, Niemeyer C., Ilyasof K., Koehler G., Langer M.
  Osteosarcoma: Preliminary results of in vivo assessment of tumor necrosis during chemotherapy with diffusion weighted MR-imaging.
  Pediatric Radiology 36(12):1306-11
  

• Paul D, Hennig J, Zaitsev M.
  Intrinsic Fat Suppression in TIDE Balanced Steady-State Free Precession Imaging.
  Magn Reson Med 56:1328-35
  

• Paul D, Markl M, Fautz HP, Hennig J.
  T2-weighted balanced SSFP-imaging (T2-TIDE) using variable flip angles.
  Magn Reson Med 56:82-93
  

2005

• von zur Muehlen C, von Elverfeldt D, Choudhury R, Bode C, Peter K
  A Single-chain Antibody Directed Against Activated Platelets Allows Targeted Magnetic Resonance Imaging of Human Thrombi at Clinically Relevant Field Strengths.“
  AHA 2005, Circulation 112 (17) supplement: 1092

• Reichardt W, Hu-Lowe D, Torres D, Weissleder R, Bogdanov A Jr
  Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma model
  Neoplasia. 2005 Sep;7(9):847-5

• Kim YR, Yudina A, Figueiredo J, Reichardt W, Hu-Lowe D, Petrovsky A, Kang HW, Torres D, Mahmood U, Weissleder R, Bogdanov AA Jr.
  Detection of early antiangiogenic effects in human colon adenocarcinoma xenografts: in vivo inhibitor.
  Cancer Res. 2005 Oct 15;65(20):9253-60 

• Hentschel M, Paul D, Korsten-Reck U, Mix M, Müller F, Merk, S, Brink I, Moser E
  Can body volume be determined by PET?
  Eur J Nucl Med Mol Imaging 32:564-68

2004   

• Niekisch M, von Elverfeldt D, El Saman A, Hennig J, Kirste G.
  Improved Pretransplant Assessment of Renal Quality via 31P-Magnetic Resonance Spectroscopy Employing Chemical Shift Imaging
  Transplantation 2004 77(7):1041-1045

• Fautz HP, Paul D, Scheffler K, Hennig J.
  TRIM: TR Independent Multislice Imaging.
  Magn Reson Med 51:1239-46
  

• Bilecen D, Kaspar A, Küstermann E, Seelig J, Elverfeldt D, Scheffler K.
  Intrahepatic detection of the non-steroidal antirheumatic drug niflumic acid followed by in vivo and in vitro 19F MR spectroscopy in humans
  NMR Biomed. 2003 May;16(3):144-51

* These authors contributed equally

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Former group members

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