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Bolus-Tracking Perfusion and Vessel Size Imaging in the Brain

Measurements of cerebral blood volume and flow via tracking the first passage of a bolus of exogenous contrast agent (DSC MRI) is a recognized tool in the diagnostics of stroke and intracranial tumors. However, the method still suffers from large interindividual variability, dependence on operator and on data processing algorithms. Empirically, the temporal characteristics of the bolus passage demonstrate a better prognostic value in acute stroke than the blood flow, which in theory is the central physiological quantity. I believe that the minor role of blood flow is a manifestation of the poor quantitation of tissue parameters. The goal of this project is to develop a robust quantitative, operator-independent DSC MRI for the clinical needs. Our current focus is on a reliable measurement of the arterial input function. The results will better delineate the biophysical content of the measurement and will be quantitatively validated using Positron Emission Tomography (PET).

Related publications

• Xu C, Schmidt WU, Villringer K, Brunecker P, Kiselev V, Gall P, Fiebach JB. Vessel size imaging reveals pathological changes of microvessel density and size in acute ischemia. J Cereb Blood Flow Metab. 2011 Apr 6. [Epub ahead of print]
• Gall P, Emerich P, Kjølby BF, Kellner E, Mader I, Kiselev VG. On the design of filters for Fourier and oSVD-based deconvolution in bolus tracking perfusion MRI. Magnetic Resonance Materials in Physics, Biology and Medicine (MAGMA) 23(2010)187-195
• Gall P, Mader I, Kiselev VG. Extraction of the first bolus passage in dynamic susceptibility contrast perfusion measurements. Magnetic Resonance Materials in Physics, Biology and Medicine (MAGMA) 22(2009)241-249.
• Kjølby BF, Mikkelsen IK, Pedersen M, Østergaard L, Kiselev VG. Analysis of partial volume effects on arterial input functions using gradient echo: a simulation study. Magnitec Resonance in Medicine 61(2009)1300-1309.
• Kjølby BF, Østergaard L, Kiselev VG. Theoretical model of intravascular paramagnetic tracers effect on tissue relaxation. Magnetic Resonance in Medicine 56 (2006) 187 - 97.
• Kiselev VG. Transverse relaxation effect of MRI contrast agents: A crucial issue for quantitative measurements of cerebral perfusion. J Magn Reson Imaging 22 (2005) 693–696.
• Kiselev VG, Strecker R, Ziyeh S, Speck O, Hennig J. Magnetic Resonance in Medicine 53 (2005) 553-63. Magnetic Resonance in Medicine 53 (2005) 553-63.
• Kiselev VG. On the theoretical basis of perfusion measurements by dynamic susceptibility contrast MRI. Magn Reson Med. 46 (2001) 1113-22.

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