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Laura-Adela Harsan

Contact: Dr. Laura-Adela Harsan Medical Physics Department of Diagnostic Radiology University Hospital Freiburg Hugstetter Str. 55 79106 Freiburg phone: +49 761 270 9380 fax: +49 761 270 3831 e-mail: laura.harsan@uniklinik-freiburg.de

Research Interests

• DT-MRI of the rodent brain
• Development of therapeutic strategies for white matter disorders
• Molecular Imaging

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Projects

• Sexual Dimorphism in Demyelination and Recovery: In Vivo Brain Magnetic Resonance Imaging of a Mouse Model of Multiple Sclerosis 

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Publications

Journal papers

• L.A. Harsan, J. Steibel, A. Zaremba, R. Sapin, A. Agin, P. Poulet, B. Guignard, N. Parizel, N. Boehm, R. Miller and MS Ghandour.
  Recovery from chronic demyelination by thyroid hormone therapy: myelinogenesis induction and assessment by diffusion tensor magnetic resonance imaging.
  The Journal of Neuroscience 2008 Dec 24;28(52):14189-201.
  
• L.A. Harsan, P. Poulet, B. Guignard, N. Parizel, R.P. Skoff and MS Ghandour.
  Astrocytic Hypertrophy in Dysmyelination Influences the Diffusion Anisotropy of White Matter.
  J Neurosci Res. 2007 Apr;85(5):935-44
  
• L.A. Harsan, P. Poulet, B. Guignard, J. Steibel, N. Parizel, P. Loureiro de Sousa, N. Boehm, D. Grucker and MS Ghandour.
  Brain dysmyelination and recovery assessment by non-invasive in vivo diffusion tensor magnetic resonance imaging.
  J Neurosci Res. 2006 Feb 15;83(3):392-402
  
• L.A. Harsan, W. Jalabi, D. Grucker, MS Ghandour.
  New insights on neuronal alterations in jimpy mutant brain.
  Neurochem Res. 2004 May; 29(5):943-52
  
• G. Driessens*, L. Harsan*,B. Robaye,D. Waroquier,P. Browaeys,X. Giannakopoulos,T. Velu,C. Bruyns.
  Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour.
  British Journal of Cancer, 2003 Aug 18. 89(4): 727-9. * The first two authors equally contributed to this work
  
• G. Driessens*, L. Harsan*,P. Browaeys,X. Giannakopoulos,T. Velu,C. Bruyns.
  Assessment of in vivo chemotherapy-induced DNA damage in a p53-mutated rat tumor by micronuclei assay.
  Ann N Y Acad Sci. 2003 Dec. 1010:775-9. * The first two authors equally contributed to this work.
  
• L.A. Harsan, P. Poulet, B. Guignard, J. Steibel, N. Parizel, P. Loureiro de Sousa, N. Boehm, D. Grucker and MS Ghandour.
  Monitoring brain myelination by diffusion tensor magnetic resonance imaging.
  Biophotonics for Life Sciences and Medicine (Eds M. Faupel et al., Fontis Media Press, 2006) 239-255.
  

Conference abstracts (as first author)

• L.A. Harsan, D. Paul, D. von Elverfeldt, J. Steibel, J. Hennig and MS Ghandour. Mouse Brain Diffusion Tensor Magnetic Resonance Imaging (DT-MRI):Assessment of Demyelination and Recovery. ISMRM Meeting, Toronto, Canada, 3-9 May 2008 (Poster award, 1-st prize, MRI in Drug Research)
• L.A. Harsan, D. Paul, S. Schnell, B. Kreher, J. Hennig and D. von Elverfeldt. In-Vivo White Matter Characterization and Fiber Tracking of the Mouse Brain. WMSG, Pathogenesis and Mechanisms of White Matter Injury, Krakow, Poland, 23-26 Sept. 2008
• L.A. Harsan, D. Paul, D. von Elverfeldt, J. Steibel, J. Hennig and MS Ghandour. Monitoring Demyelination and Recovery:In vivo Mouse Brain Diffusion Tensor Magnetic Resonance Imaging. WMSG, Pathogenesis and Mechanisms of White Matter Injury, Krakow, Poland, 23-26 Sept. 2008
• L.A. Harsan, J. Steibel, P. Poulet, B. Guignard, N. Parizel, D. Grucker, N. Boehm, and MS Ghandour. DT-MRI of Myelination Abnormalities and Recovery: Fine Microstructural Analysis of Brain White Matter.Neurex Annual Meeting, Freiburg 22 June 2007 (lecture prize)
• L.A. Harsan, J. Steibel, A. Agin, P. Poulet, B. Guignard, N. Parizel, D. Grucker, and MS Ghandour. In Vivo DT-MRI Assessment of Thyroid Hormone Induced Remyelination of the Mouse Brain.Franco-Italian Meeting on Multiple Sclerosis,Paris, 23-rd March 2007
• L.A. Harsan, J. Steibel, A. Agin, P. Poulet, B. Guignard, N. Parizel, D. Grucker, and M.S. Ghandour. Diffusion Tensor Magnetic Resonance Imaging Assesment of Brain Remyelination Induced by Thyroid Hormone Based Therapy.36th Annual Meeting of the American Society for Neuroscience Atlanta 14-18 Oct 2006
• L.A. Harsan, P. Poulet, B Guignard, N. Parizel, D. Grucker, R.P. Skoff and M.S. Ghandour. Noninvasive In Vivo Imaging of Myelin Defects and Recovery in a Mouse Model of PMD.European Leukodystrophy Society Meeting, Paris 4-7 Oct 2006.
• L.A. Harsan, A.S. Gonul, P. Poulet, B Guignard, N. Parizel, T. Guiberteau, D. Grucker, R.P. Skoff and M.S. Ghandour. Myelination defects assessed by diffusion tensor magnetic resonance imaging in jimpy mutant brain.35-th Annual Meeting of the American Society for Neuroscience Washington 12-16 Nov 2005
• L.A. Harsan, A.S. Gonul, P. Poulet, B Guignard, N. Parizel, T. Guiberteau, D. Grucker, R.P. Skoff and M.S. Ghandour. Diffusion Tensor Magnetic Resonance Imaging of Hypomyelinated Jimpy Mutant Brain.ESMRMB 2005, Basel 15-18 September 2005-ESMRMB Student Stipend Grant
• L.A. Harsan, P. Poulet, B. Guignard, N. Parizel,P. Loureiro de Sousa, N. Boehm, D. Grucker, and M.S. Ghandour. Monitoring brain myelination by diffusion tensor MRI in a transgenic mouse model.34-th Annual Meeting of the American Society for Neuroscience -San Diego, USA 22-28 oct 2004.
• L.A. Harsan, P. Poulet, B. Guignard, N. Parizel,P. Loureiro de Sousa, N. Boehm, D. Grucker, and M.S. Ghandour. Brain Myelination by Diffusion Tensor Magnetic Resonance Imaging.ARSEP, Paris, 14 dec. 2004 –Best poster award

PhD Thesis

• Brain Myelination Abnormalities and Recovery Assessment by Diffusion Tensor Magnetic Resonance Imaging (DT-MRI). Laboratory of In Vivo Neuroimaging, UMR 7004, School of Medicine, CNRS/Université Louis Pasteur, Strasbourg, France

Diploma Thesis

• Micronuclei as a tool to evaluate tumor damage following radiotheraphy and chemotherapy within a rat model. "Babes-Bolyai" University, Cluj-Napoca, Romania. SOCRATES fellowship at Université Libre de Bruxelles, Belgium.

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