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Dr. Jan-Bernd Hövener

Contact: Dr. Jan-Bernd Hövener Medical Physics Department of Diagnostic Radiology University Hospital Freiburg Breisacher Str. 60a 79106 Freiburg phone: +49 761 270 93910 fax: +49 761 270 93790 e-mail: jan.hoevener@uniklinik-freiburg.de

Research Interests

• hyperpolarization and parahydrogen
• magnetic resonance spectroscopy, whole brain NAA

Projects

• AMIR: Advanced Molecular Imaging Research Center

Publications

Journal papers

• Hövener J-B, Rigotti D, Amann M, Liu S, Babb J.S, Bachert P, Grossman R.I and Gonen O: “Whole-Brain N acetylaspartate MR Spectroscopic Quantification - Performance Comparison of Metabolite Versus Lipid Nulling”, American Journal of Neuroradiology 29: 1441-1445, 2008.
  
  
• Chekmenev E, Hövener J-B, Norton V.A, Harris K, Batchelder L.S, Bhattacharya P, Ross B.D and Weitekamp D.P: “PASADENA Hyperpolarization of Succinic Acid for MRI and NMR spectroscopy”. Journal of the American Chemical Society 130: 4212 – 4213, 2008. 
   
• Hövener J-B, Chekmenev E, Harris K, Perman W, Robertson L.W, Ross B.D and Bhattacharya P: “PASADENA Hyperpolarization of ¹³C Biomolecules: Equipment Design and Installation”, Magnetic Resonance Materials in Physics, Biology and Medicine 22 (2): 111 – 121, 2009.
   
• Hövener J-B, Chekmenev E, Harris K, Perman W, Tran T, Ross B.D and Bhattacharya P: “Quality Assurance of PASADENA Hyperpolarization for ¹³C Biomolecules”. Magnetic Resonance Materials in Physics, Biology and Medicine 22 (2): 123 – 134, 2009.
   
• Chekmenev E, Chow S, Tofan D, Hövener J-B, et al.: “Development of novel ¹³C hyperpolarized contrast agents for magnetic resonance imaging of atheriosclerotic plaque”. Journal of Magnetic Resonance, submitted 2008.
   
• Xu V, Chan H, Lin A, Sailasuta N, Valencerina S, Tran T, Hovener, J, Ross B.D: MR Spectroscopy in Diagnosis and Neurological Decision-Making. Seminars in Neurology 28 (4), 2008.
  

Conference abstracts (as first author)

• Hövener J-B, Chekmenev E, et al.: “Quality assurance of PASADENA hyperpolarization for ¹³C Biomolecules”. Experimental NMR Conference (ENC) 2008, Asilomar, USA.
   
• Hövener, Jan-Bernd: "Strategies to prolong T1 in hyperpolarized ¹⁵N and ¹³C nuclei”. Proceedings of the 16th Scientific Meeting ISMRM 2008, Toronto, Canada.
   
• Hövener J-B,Chekmenev E, et al.: “Reproducibility and quality assurance in hyperpolarized ¹³C MRI and MRS”. Proceedings of the 15th Scientific Meeting ISMRM 2007, Berlin, Germany.
   
•  Hövener J-B, Lin A, et al.: “Neurospectroscopy will miss the boat – AGAIN: The unmet need for universal standards and a database”. Proceedings of the 15th Scientific Meeting ISMRM 2007, Berlin, Germany.
   
• Hövener J-B, Bachert P: “Experimental approach to determine non-invasively the total content of N-acetyl-L-aspartate (NAA) in the human brain”. Int. Conference of Medical Physics 2005, Nürnberg, Germany, and published in Biomedizinische Technik, 2005: 50 (suppl. vol. 1, part 1): 1178 – 1179.

PhD Thesis

¹³C spin hyperpolarization by PASADENA: Instrumentation, preparation of magnetic tracers, and NMR spectroscopy and imaging in vivo.

Diploma Thesis

Development of a technique to determine noninvasively the total content of N-Acetyl-L-Aspartat in the human brain in vivo.

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