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Pierre LeVan

Contact: Pierre LeVan University Medical Center Freiburg Department of Radiology Medical Physics Breisacher Str. 60a 79106 Freiburg Personalhaus (PH) 2a Room 01.037 phone: +49 761 270 93730 fax: +49 761 270 38310 pierre.levan@uniklinik-freiburg.de

Research Interests

• Ultra-fast fMRI
• Simultaneous EEG-fMRI

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Projects

• Advanced Brain Imaging 

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Publications

Journal papers

• Zahneisen B, Hugger T, Lee KJ, LeVan P, Reisert M, Lee HL, Assländer J, Zaitsev M, Hennig J
  Single shot concentric shells trajectories for ultra fast fMRI
  Magn Reson Med. (In press)
  
• Hugger T, Zahneisen B, LeVan P, Lee KJ, Lee HL, Zaitsev M, Hennig J
  Fast undersampled functional magnetic resonance imaging using nonlinear regularized parallel image reconstruction
  PLoS One. 2011;6(12):e28822
  
• Pittau F, LeVan P, Moeller F, Gholipour T, Haegelen C, Zelmann R, Dubeau F, Gotman J
  Changes preceding interictal epileptic EEG abnormalities: comparison between EEG/fMRI and intracerebral EEG
  Epilepsia. 2011;52(6):1120-9
  
• Moeller F, LeVan P, Gotman J
  Independent Component Analysis (ICA) of generalized spike wave discharges in fMRI: Comparison with general linear model-based EEG-fMRI
  Hum Brain Mapp. 2011;32(2):209-17
  
• Moeller F, LeVan P, Muhle H, Stephani U, Dubeau F, Siniatchkin M, Gotman J
  Absence seizures: individual patterns revealed by EEG-fMRI
  Epilepsia. 2010;51(10):2000-10
  
• Rathakrishnan R, Moeller F, LeVan P, Dubeau F, Gotman J
  BOLD signal changes preceding negative responses in EEG-fMRI in patients with focal epilepsy
  Epilepsia. 2010;51(9):1837-45
  
• LeVan P, Tyvaert L, Gotman J
  Modulation by EEG features of BOLD responses to interictal epileptiform discharges
  Neuroimage. 2010;50(1):15-26
  
• LeVan P, Tyvaert L, Moeller F, Gotman J
  Independent component analysis reveals dynamic ictal BOLD responses in EEG-fMRI data from focal epilepsy patients
  Neuroimage. 2010;49(1):366-78
  
• Tyvaert L, Chassagnon C, Sadikot AF, LeVan P, Dubeau F, Gotman J
  Thalamic nuclei activity in idiopathic generalized epilepsy: an EEG-fMRI study
  Neurology. 2009;73(23):2018-22.
  
• Moeller M, Tyvaert L, Nguyen DK, LeVan P, Bouthillier A, Kobayashi E, Tampieri D, Dubeau F, Gotman J
  EEG-fMRI: adding to standard evaluations of patients with nonlesional frontal lobe epilepsy
  Neurology. 2009;73(23):2023-30.
  
• Tyvaert L, LeVan P, Dubeau F, Gotman J
  Non-invasive dynamic imaging of seizures in epileptic patients
  Hum Brain Mapp. 2009;30(12):3993-4011.
  
• Yu JM, Tyvaert L, LeVan P, Zelmann R, Dubeau F, Gotman J, Kobayashi E
  EEG spectral changes underlying BOLD responses contralateral to spikes in patients with focal epilepsy
  Epilepsia. 2009;50(7):1804-1809
  
• LeVan P, Gotman J
  Independent component analysis as a model-free approach for the detection of BOLD changes related to epileptic spikes: a simulation study
  Hum Brain Mapp. 2009;30(7):2021-2031
  
• Jacobs J, LeVan P, Moeller F, Boor R, Stephani U, Gotman J, Siniatchkin M
  Hemodynamic changes preceding the interictal EEG spikes in patients with focal epilepsy investigated using simultaneous EEG-fMRI
  Neuroimage. 2009;45(4):1220-31
  
• Jacobs J, LeVan P, Châtillon CE, Olivier A, Dubeau F, Gotman J
  High frequency oscillations in intracranial EEGs mark epileptogenicity rather than lesion type
  Brain. 2009;132(Pt 4):1022-37
  
• Bagshaw AP, Jacobs J, LeVan P, Dubeau F, Gotman J
  Effect of sleep stage on interictal high-frequency oscillations recorded from depth macroelectrodes in patients with focal epilepsy
  Epilepsia. 2009;50(4):617-28
  
• Jacobs J, LeVan P, Olivier A, Andermann F, Dubeau F
  Late onset epilepsy in a surgically-treated Sturge-Weber patient
  Epileptic Disord. 2008;10(4):312-8
  
• Tyvaert L, LeVan P, Grova C, Dubeau F, Gotman J
  Effects of fluctuating physiological rhythms during prolonged EEG-fMRI studies
  Clin Neurophysiol. 2008;119(12):2762-74
  
• Jacobs J, LeVan P, Chander R, Hall J, Dubeau F, Gotman J
  Interictal high-frequency oscillations (80-500 Hz) are an indicator of seizure onset areas independent of spikes in the human epileptic brain
  Epilepsia. 2008;49(11):1893-907
  
• Tyvaert L, Hawco C, Kobayashi E, LeVan P, Dubeau F, Gotman J
  Different structures involved during ictal and interictal epileptic activity in malformations of cortical development: an EEG-fMRI study
  Brain. 2008;131(Pt 8):2042-60
  
• Jacobs J, Rohr A, Moeller F, Boor R, Kobayashi E, LeVan P, Stephani U, Gotman J, Siniatchkin M
  Evaluation of epileptogenic networks in children with tuberous sclerosis complex using EEG-fMRI
  Epilepsia. 2008;49(5):816-25
  
• Jacobs J, Hawco C, Kobayashi E, Boor R, LeVan P, Stephani U, Siniatchkin M, Gotman J
  Variability of the hemodynamic response as a function of age and frequency of epileptic discharge in children with epilepsy
  Neuroimage. 2008;40(2):601-14
  
• Iriarte J, Urrestarazu E, Artieda J, Valencia M, LeVan P, Viteri C, Alegre M
  Independent Component Analysis in the Study of Focal Seizures
  J Clin Neurophysiol. 2006;23(6):551-8
  
• Jirsch JD, Urrestarazu E, LeVan P, Olivier A, Dubeau F, Gotman J
  High frequency oscillations during human focal seizures
  Brain 2006;129(Pt 6):1593-608
  
• Urrestarazu E, Jirsch JD, LeVan P, Hall J, Avoli M, Dubeau F, Gotman J
  High frequency intracerebral EEG activity (100-500Hz) following interictal spikes
  Epilepsia 2006;47(9):1465-76
  
• Urrestarazu E, LeVan P, Gotman J
  Independent component analysis identifies ictal bitemporal activity in intracranial recordings at the time of unilateral discharges
  Clin Neurophysiol 2006;117(3):549-61
  
• LeVan P, Urrestarazu E, Gotman J
  A system for automatic artifact removal in ictal scalp EEG based on independent component analysis and Bayesian classification
  Clin Neurophysiol 2006;117(4):912-27
  

Book chapters

• LeVan P, Gotman J
  Automatic detection of epileptic spikes
  In: Lüders HO, editor. Textbook of Epilepsy Surgery, Informa HealthCare, London, UK, 2008
  
• LeVan P, Gotman J
  Computer-assisted data collection and analysis
  In: Engel J Jr., Pedley TA, Aicardi J, editors. Epilepsy: A Comprehensive Textbook, 2nd edition, Lippincott Williams & Wilkins, Philadelphia, 2007
  

PhD Thesis

• Independent component analysis of simultaneously acquired electroencephalography and functional magnetic resonance imaging in focal epilepsy patients

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CV

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