• Kontakt
• So finden Sie uns
• Klinikumseinrichtungen
• Presse

Publikationen

Originalarbeiten

Volz F, Bock HH, Gierthmuehlen M, Zentner J, Haas CA, Freiman TM (2011) Stereological estimation of hippocampal mossy cells in two mouse models of temporal lobe epilepsy. Epilepsia, 52 (9), 1579-89.  

Häussler U, Bielefeld L, Froriep UP, Wolfart J, Haas CA (2011) Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy. Cereb Cort (in press).  

Pallud J, Häussler U, Langlois M, Hamelin S, Devaux B, Deransart C, Depaulis A. (2011) Dentate gyrus and hilus transection blocks seizure propagation and granule cell dispersion in a mouse model for mesial temporal lobe epilepsy. Hippocampus, 21, 334--343.  

Heinrich C, Lahteinen S, Suzuki F, Laharie, AM, Huber S, Häussler U, Haas CA, Larmet Y, Castren E, Depaulis A (2011) Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy. Neurobiol Dis, 42, 35-47.  

Tinnes S, Schäfer M, Flubacher A, Münzner G, Frotscher M, Haas CA (2011) Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning. FASEB Journal, 25, 1002–1013.  

Gross CM, Flubacher A, Tinnes S, Heyer A, Scheller M, Herpfer I, Berger M, Frotscher M, Lieb K, Haas CA (2011) Early life stress stimulates hippocampal reelin gene expression in a sex-specific manner: Evidence for corticosterone-mediated action. Hippocampus (in press doi: 10.1002/hipo.20907) 

Wagener R, Dávid C, Zhao S, Haas CA, Staiger J (2010) The somatosensory cortex of reeler mutant mice shows absent layering but intact formation and behavioral activation of columnar somatotopic maps. J Neurosci, 30, 15700-09.  

Kowalski J, Geuting M, Sebastian P, Dieni S, Laurens J, Zhao S, Drakew A, Haas CA, Frotscher M, Vida I (2010) Proper layering is important for precisely timed activation of hippocampal mossy cells. Cereb Cort, 20(9), 2043-54. 

Lugert S, Basak O, Knuckles P, Haussler U, Fabel K, Gotz M, Haas CA, Kempermann G, Taylor V, Giachino C (2010) Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and ageing. Cell Stem Cell, 6, 401-2. 

Haas CA, Frotscher M (2010) Reelin deficiency causes granule cell dispersion in epilepsy. Exp Brain Res, 200, Special Issue, 141-149. 

Frotscher M, Chai X, Bock H, Haas CA, Förster E, Zhao S (2009) Role of Reelin in the development and maintenance of cortical lamination. J Neural Transm, 116 (11), 1451-1455. 

Mantovani M, Moser A, Haas CA, Zentner J, Feuerstein TJ (2009) GABA (A) autoreceptors enhance GABA release from human neocortex: towards a mechanism for high-frequency stimulation (HFS) in brain? Naunyn-Schmied Arch Pharmacol, 380, 45–58.  

Müller MC, Osswald M, Tinnes S, Häussler U, Jacobi A, Förster E, Frotscher M, Haas CA (2009) Exogenous reelin prevents granule cell dispersion in experimental epilepsy. Exp Neurol, 216, 390-397. 

Stegen M, Young C, Haas CA, Zentner J, Wolfart J (2009) Increased leak conductance in dentate gyrus granule cells of temporal lobe epilepsy patients with Ammon’s horn sclerosis. Epilepsia, 50, 646-653. 

Young C, Stegen M, Bernard R, Müller M, Bischofberger J, Veh RW, Haas CA, Wolfart J (2009) Upregulation of inward rectifier K+ (Kir2) Channels in dentate gyrus granule cells in temporal lobe epilepsy. J Physiol (London), 587 (17), 4213-4233. 

Najm J, Horn D, Wimplinger I, Golden JA, Chizhikov V, Sudi J, Christian SL, Ullmann R, Kuechler A, Haas CA, Flubacher A, Charnas LA, Uyanik G, Frank U, Klopocki E, Dobyns WB, Kutsche K (2008) Mutations of CASK cause a novel X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum. Nature Genetics, 40, 1065-1067. 

Deller T, Bas Orth C, Del Turco D, Vlachos A, Burbach GJ, Drakew A, Chabanis S, Korte M, Schwegler H, Haas CA, Frotscher M (2007) A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticity. Ann Anat, 189 (1), 5-16. 

Fahrner A, Kann G, Flubacher A, Heinrich C, Freiman TM, Zentner J, Frotscher M, Haas CA (2007) Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients. Exp Neurol, 203 (2), 320-332. 

Deller T, Haas CA, Freiman TM, Phinney A, Jucker M, Frotscher M (2006) Lesion-induced axonal sprouting in the central nervous system. Adv Exp Med, 557, 101-21. 

Heinrich C, Nitta N, Flubacher A, Müller M, Fahrner A, Kirsch M, Freiman T, Suzuki F, Depaulis A, Frotscher M, Haas CA (2006) Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus. J Neurosci, 26, 4701-4713. 

Schwarzacher SW, Vuksic M, Haas CA, Burbach GJ, Sloviter RS, Deller T (2006) Neuronal hyperactivity induces astrocytic expression of neurocan in the adult hippocampus. Glia, 53, 704-714. 

Bas Orth C, Vlachos A, del Turco D, Burbach GJ, Haas CA, Mundel P, Feng G, Frotscher M, Deller T (2005) Lamina-specific distribution of synaptopodin, an actin-associated molecule essential for the spine apparatus, in identified principal cell dendrites of the mouse hippocampus. J Comp Neurol, 487, 227-239. 

Czarnecki K, Haas CA, Bas Ort C, Deller T, Frotscher M (2005) Postnatal development of synaptopodin expression in the rodent hippocampus: Expression by principal cells and interneurons. J. Comp Neurol, 490, 133-144. 

Haas CA (2004) Neuronale Migrationsstörungen und Epilepsie. Neuroforum, 4/04, 256-260. 

Haas CA and Frotscher M (2004) Migration disorders and epilepsy. Brain Damage and Repair, pp. 391-402. (T Herdegen and JM Delgado-Garcia eds) Luwer Academic Publishers. 

Burbach GJ, Hellweg R, Haas CA, del Turco D, Deicke U, Abramowski D, Jucker M, Staufenbiel M, Deller T (2004) Induction of brain-derived neurotrophic factor (BDNF) in plaque-associated glial cells of aged APP23 transgenic mice. J Neurosci, 24, 2421-2430. 

Kulik A, Vida I, Luján R, Haas CA, López-Bendito G, Shigemoto R, Frotscher M (2003) Subcellular localization of metabotropic GABAB receptor subunits GABAB1a/b and GABAB2 in the rat hippocampus. J Neurosci, 23, 11026-11035. 

Frotscher M, Haas CA, Förster E (2003) Reelin controls granule cell migration in the dentate gyrus by acting on the radial glial scaffold. Cereb Cortex, 13, 634 -640. 

Deller T, Haas CA, Deissenrieder K, del Turco D, Coulin C, Gebhardt C, Drakew A, Mundel P, Frotscher M (2002) The laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine bearing neurons. J Comp Neurol, 453, 33-44. 

Haas CA, Dudeck O, Kirsch M, Huszka C, Kann G, Pollak S, Zentner J, Frotscher M (2002) Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. J Neurosci, 22, 5797-5802. 

Streppel M, Azzolin N, Dohm S, Guntinas-Lichius O, Haas CA, Grothe C, Wewers A, Neiss WF, Angelov DN (2002) Focal application of neutralizing antibodies to soluble neurotrophic factors reduces collateral axonal branching after peripheral nerve lesion. Eur J Neurosci, 15, 1327-1342. 

Priller J, Flügel A, Wehner T, Boentert M, Haas CA, Prinz M, Fernández-Klett F, Prass K, Bechmann I, de Boer B, Frotscher M, Kreutzberg GW, Persons DA Dirnagl U (2001) Targeting of gene-modified hematopoietic cells to the central nervous system: use of the green fluorescent protein uncovers microglial engraftment. Nature Med, 7, 1356-1361. 

Haas CA, Hollerbach E, Deller T, Naumann T, Frotscher M (2000) Up-regulation of growth-associated protein 43 mRNA in rat medial septum neurons axotomized by fimbria-fornix transection. Eur J Neurosci, 12, 4233-4242. 

Deller T, Haas CA, Frotscher M (2000) Reorganization of the rat fascia dentata after a unilateral entorhinal cortex lesion: Role of the extracellular matrix. Ann NY Acad Sci, 911, 207-220. 

Thon N, Haas CA, Rauch U, Merten T, Frotscher M, Deller T (2000) The chondroitin sulfate proteoglycan brevican is up-regulated by astrocytes after entorhinal cortex lesions in adult rats. Eur J Neurosci, 12, 2547-2558. 

Haas CA, Deller T, Krsnik Z, Tielsch A, Woods A and Frotscher M (200) Entorhinal cortex lesion does not alter reelin mRNA expression in the dentate gyrus of young and adult rats. Neuroscience, 97, 25-31. 

Haas CA, Hofmann H-D, Kirsch M. (1999) Expression of CNTF/LIF-receptor components and activation of STAT3 signaling in axotomized facial motoneurons: evidence for a sequential postlesional function of the cytokines. J Neurobiol, 41, 559-571. 

Haas CA, Rauch U, Thon N, Merten T, Deller T (1999) Entorhinal cortex lesion in adult rats induce the expression of the neuronal chondroitin sulfate proteoglycan neurocan in reactive astrocytes. J Neurosci, 19, 9953-9963. 

Haas CA, Frotscher M, Deller T (1999) Differential induction of c-Fos, c-Jun and Jun B in the rat central nervous system following unilateral entorhinal cortex lesion. Neuroscience, 90, 41-52. 

Haas CA, Frotscher M (1998) Role of NGF in axotomy-induced c-Jun expression in medial septal cholinergic neurons. Int J Dev Neurosci, 16, 691-703. 

Priller J, Haas CA, Reddington M, Kreutzberg GW (1998) Cultured astrocytes express functional receptors for galanin. Glia, 24, 323-328. 

Haas CA, Bach A, Heimrich B, Linke R, Otten U, Frotscher M (1998) Axotomy-induced c-Jun expression in young medial septal neurons is regulated by nerve growth factor. Neuroscience, 87, 831-844. 

Priller J, Reddington M, Haas CA, Kreutzberg GW (1998) Stimulation of P2y-purinoceptors on astrocytes result in immediate early gene expression and potentiation of neuropeptide action. Neuroscience, 85, 521-525. 

Hollerbach EH, Haas CA, Hildebrandt H, Frotscher M, Naumann T (1998) Region-specific activation of microglial cells in the rat septal complex following fimbria-fornix transection. J Comp Neurol, 390, 481-496. 

Deller T, Haas CA, Naumann T, Joester A, Faissner A and Frotscher M (1997) Upregulation of astrocyte-derived tenascin-C correlates with neurite outgrowth in the rat dentate gyrus after unilateral entorhinal cortex lesion. Neuroscience, 81, 829-846. 

Haas CA, Deller T, Frotscher M (1997) Basal expression, subcellular distribution and upregulation of the proto-oncogene c-Jun in the rat dentate gyrus after unilateral entorhinal cortex lesion. Neuroscience, 81, 33-45. 

Haas CA, Deller T, Naumann T, Frotscher M (1996) Selective expression of the immediate early gene c-Jun in axotomized rat medial septal neurons is not related to neuronal degeneration. J Neurosci, 16, 1884-1903. 

Reddingotn M, Priller J, Treichel J, Haas CA and Kreutzberg GW (1995) Astrocytes and microglia as potential targets for calcitonin gene-related peptide in the central nervous system Can. J Physiol Pharmacol, 73, 1047-1049. 

Priller J, Haas CA, Reddington M, Kreutzberg GW (1995) Calcitonin gene-related peptide and ATP induce immediate early gene expresson in cultured rat microglia cells. Glia, 15, 447-457. 

Reddington M, Haas CA, Kreutzberg GW (1994) The plasminogen activator system in neurons and glia during motoneuron regeneration. Neuropath Appl Neurobiol, 20, 188-190. 

Cavalie A, Berninger B, Haas CA, Garcia DE, Lindholm D, Lux HD (1994) Constitutive up-regulation of calcium channel currents in phaeochromocytoma cells: role of c-fos and c-jun. J Physiol, 479 (1), 11-27. 

Haas CA, Donath C, Kreutzberg GW (1993) Differential induction of immediate early genes after transection of the facial nerve. Neuroscience, 53, 91-99. 

Kiefer R, Haas CA, Kreutzberg GW (1991) Gamma interferon-like immunoreactive material in rat neurons: evidence against a close relationship to gamma interferon. Neuroscience, 45, 551-560. 

Haas CA, Reddington M, Kreutzberg GW (1991) Calcitonin gene-related peptide stimulates the induction of c-fos gene expression in rat astrocyte cultures. Eur J Neurosci, 3, 708-712. 

Haas CA, Streit WJ, Kreutzberg GW (1990) Rat facial motoneurons express increased levels of calcitonin gene-related peptide mRNA in response to axotomy. J Neurosci Res, 27, 270-275. 

Haas CA, DeGennaro LJ, Müller M, Holländer H (1990) Synapsin I expression in the rat retina during postnatal development. Exp Brain Res, 82, 25-32. 

Haas CA, DeGennaro LJ (1988) Multiple synapsin I mRNAs are differentially regulated during neuronal development. J Cell Biol, 106, 195-203. 

Übersichtsartikel

Deller T.,Haas C.A., Freiman T.M., Phinney A., Jucker M. and Frotscher M. (2003) Lesion-induced axonal sprouting in the central nervous system. In: Brain Repair (M. Bähr, ed.). Landes Bioscience, Georgetown.

Deller T.,Haas C.A., and Frotscher M. (2001) Sprouting in the hippocampus after entorhinal cortex lesion is layer-specific but not translaminar: which molecules may be involved? Rest. Neurol. Neurosci. 19, 159-167.

Frotscher M., Deller T., Heimrich B., Förster E.,Haas C.A. and Naumann T. (1996) Survival, regeneration, and sprouting of central neurons: the rat septohippocampal projection as a model. Ann. Anat. 178, 311-315.

Raivich G., Reddington M., Haas C.A. and Kreutzberg G.W. (1995) Peptides in motoneurons (In: Neuropeptides in the Spinal Cord, Eds. F. Nyberg; H.S. Sharma and Z. Wiesenfeld-Hallin) Prog. Brain Res. 104, 1-20.

Dumoulin F.L., Raivich G.,Haas C.A., Lazar P., Reddington M., Streit W.J. and Kreutzberg G.W (1992) Calcitonin gene-related peptide and peripheral nerve regeneration. Ann. N. Y. Acad. Sci. 657, 351-360.

Buchbeiträge

Frotscher M.,Haas C.A. (2009) Epilepsy-associated reelin dysfunction induces granule cell dispersion in the dentate gyrus. In: Encyclopedia of Basic Epilepsy Research Oxford. Schwartzkroin PA (ed), Elsevier pp.192-198. (Vol.1)

Martin R.,Haas C.A., and Voigt K.H. (1986) Opioid and related neuropeptides in molluscan neurons in CRC Handbook of Comparative Opioid and Related Neuropeptide Mechanisms, pp.49-64, Stefano G.B (ed).

DeGennaro L.J., Kilimann M.W., and Haas C.A. (1986) Analysis of synapsin I and G-substrate gene expression by cDNA cloning and in situ hybridization histochemistry, in Role of RNA and DNA in Brain Function, a Molecular Approach, pp.71-80. Giudetta A., Kaplan B.B., Zomzely-Neurath C. (eds).