Studies in medicine and philosophy at the Universities of Ulm, Tübingen
and Los Angeles
1992
Doctoral thesis (Dr. med., M.D.) "summa cum laude"
1992 - 1994
Physician and scientific assistant at the Departments of Internal
Medicine I and Anatomy and Cell Biology of the University of Ulm,
Germany
1994 - 1999
Physician and scientific assistant at the Departments of Psychiatry and
Psychotherapy and Neurology of Freiburg University, Germany
1999
"Venia legendi" in Psychiatry
since 2000
Senior physician at the Department of Psychiatry and Psychotherapy of
Freiburg University Medical School
since 2001
Deputy Director at the Department of Psychiatry and Psychotherapy of
Freiburg University Medical School
Main scientific interests
Neurobiology and therapy of affective disorders and borderline personality disorder
Neurobiology:
• Neurobiology and genetics of borderline personality disorder
• Brain imaging in borderline personality disorder
• Regulation and modulation of neuropeptides such as substance P and its receptor at the molecular level; interactions with psychopharmacological drugs
• Target genes for substance P (array technology)
• Animal models for affective disorders (postnatal stress etc.)
Therapy:
• Psychotherapy and pharmacotherapy of borderline personality disorder
• Treatment of affective disorders with neurokinin receptor antagonists
Neuroimmunomodulation in neurodegenerative disorders and internal medicine
• Neuroimmunomodulation by neuropeptides such as substance P and neurotransmitter such as serotonin
• Gene regulation of cytokines such as interleukin-6 and interleukin-8
• Side effects and effects in the CNS of interferon alpha
• Borna virus infection and psychiatric disorders
Contact
Department of Psychiatry and Psychotherapy
University of Freiburg Medical School
Hauptstr. 5
D 79104 Freiburg
Tel.: (+49) 761/270-6681 (Secretary -6529 or -6518)
⇒ For full reference list use "pubmed"
(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi) and search for
"Lieb K not Lieb KP"
K. Lieb, M. Zanarini, C. Schmahl, M.M. Linehan, M. Bohus: Borderline
Personality Disorder. Lancet 364: 453-61 (2004)
M. Bohus, B. Haaf, T. Simms, M. F. Limberger, C. Schmahl, C. Unckel,
K. Lieb, M. Linehan: Effectiveness of inpatient dialectical behavioral
therapy for borderline personality disorder - a controlled trial. Behav.
Res. Ther. 42: 487-99 (2004)
A. Philipsen, H. Richter, C. Schmahl, J. Peters, N. Rüsch, M. Bohus,
K. Lieb: Clonidine in acute aversive inner tension and self-injurious
behavior in female patients with Borderline personality disorder.
J. Clin. Psychiatry 65:1414-1419 (2004)
I. Herpfer, K. Lieb: Substance P and substance P receptor antagonists
in the pathogenesis and treatment of affective disorders.
World J Biol Psychiatry 4: 56-63 (2003)
F.D. Juengling, C. Schmahl, B. Heßlinger, D. Ebert, J.D. Bremner,
J. Gostomzyk, M. Bohus, K. Lieb: Positron emission tomography in female
patients with Borderline Personality Disorder. J. Psychiatric Res. 37:
109-115 (2003)
K. Lieb, Y. Treffurth, M. Hamke, R.S. Akundi, M. von Kleinsorgen,
B.L. Fiebich: Valproic acid inhibits substance P-induced activation of
protein kinase C epsilon and expression of the substance P receptor.
J. Neurochem. 86: 69-76 (2003)
Tebartz van Elst L, Hesslinger B, Thiel T, Geiger E, Haegele K,
Lemieux L, Lieb K, Bohus M, Hennig J, Ebert D: Frontolimbic brain
abnormalities in patients with borderline personality disorder.
A volumetric magnetic resonance imaging study. Biol. Psychiatry 54:
163-71 (2003)
N. Rüsch, L. Tebartz van Elst, P. Ludaescher, M. Wilke, H.-J. Huppertz,
T. Thiel, C. Schmahl, M. Bohus, K. Lieb, B. Hesslinger, J. Hennig,
D. Ebert: A Voxel-based Morphometric MRI Study in Female Patients with
Borderline Personality Disorder. Neuroimage 20: 385-92 (2003)
K. Lieb, Ahlvers K, Dancker K, Strohbusch S, Reincke M, Feige B,
Berger M, Riemann D, Voderholzer U: Effects of the neuropeptide
substance P on sleep, mood and neuroendocrine measures in healthy
young men. Neuropsychopharmacol. 27: 1041-49 (2002)
F. D. Juengling, O. Gut, M.A. Engelbrecht, D. Ebert, J. Rasenack,
E.U. Nitzsche, J. Bauer, K. Lieb: Prefrontal cortical hypometablism
during low dose interferon alpha treatment. Psychopharmacol. 152: 383-9
(2000)
K. Lieb, S. Brucker, M. Bach, T. Els, C.H. Lücking, M.W. Greenlee:
Impairment in preattentive visual processing in patients with
Parkinson's disease. Brain 122, 303-13 (1999)
K. Lieb, M. Maiwald, M. Berger, U. Voderholzer: Insomnia for 5 years.
Lancet [Case Report] 354, 1966 (1999)
K. Lieb, B.L. Fiebich, M. Berger, J. Bauer, K. Schulze-Osthoff:
The neuropeptide substance P activates transcription factor NF- B and
B-dependent gene expression in human astrocytoma cells. J. Immunol. 159:
4952-58 (1997)
K. Lieb, W. Hallensleben, M. Czygan, L. Stitz, P. Staeheli: No Borna
disease virus-specific RNA detected in blood from psychiatric patients
in different regions of Germany. Lancet 350: 1002 (1997)
