Suche nach Stichworten
Begriffe, Krankheiten, Einrichtungen u.v.m., verknüpft mit dem zuständigen Bereich.
Begriffe, Krankheiten, Einrichtungen u.v.m., verknüpft mit dem zuständigen Bereich.
Suche über die Einrichtungen
Im Menüpunkt "Übersicht" sind Einrichtungen unter verschiedenen Gesichtspunkten gruppiert: Kliniken, Abteilungen, Institute, Zentrale Einrichtungen und ähnliches.
Im Menüpunkt "Übersicht" sind Einrichtungen unter verschiedenen Gesichtspunkten gruppiert: Kliniken, Abteilungen, Institute, Zentrale Einrichtungen und ähnliches.
Selected publications 1974 - 2011
|
Gao, S., Von der Malsburg, A., Dick, A., Faelber, K., Schröder, G.F., Haller, O., Kochs, G., Daumke, O.: Structure of myxovirus resistance protein A reveals intra- and intermolecular domain interactions required for the antiviral function. Immunity. 35: 514-525 (2011) >PubMed Description of the crystal structure of the dynamin-like MxA GTPase providing insight into its antiviral action as a molecular machine. Preview by Sadler, A.J., and Williams B.R.G.: „Dynamiting viruses with MxA“, Immunity 35: 491 – 493 (2011). |
|
Gao, S., Von der Malsburg, A., Paeschke, S., Behlke, J., Haller, O., Kochs, G., Daumke, O.: Structural basis of oligomerization in the stalk region of dynamin-like MxA Nature. 465: 502-506 (2010) >PubMed First description of the architecture of a dynamin-like large GTPase oligomer. |
|
Grimm, D., Staeheli, P., Hufbauer, M., Koerner, I., Martínez-Sobrido, L., Solórzano, A., García-Sastre, A., Haller, O., Kochs, G.: Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene. Proc Natl Acad Sci USA. 104: 6806-6811 (2007). >PubMed Demonstration that highly pathogenic influenza viruses escape the innate host response by high speed of replication. |
|
Kochs, G., Janzen, Ch., Hohenberg, H. & Haller, O.: Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes. Proc Natl Acad Sci USA. 99: 3153-3158 (2002). >PubMed Evidence that human MxA missorts nucleocapsid proteins in infected cells. |
|
Bouloy, M., Janzen, C., Vialat, P., Khun, H., Pavlovic, J., Huerre, M. & Haller, O.: Genetic evidence for an interferon- antagonistic function of Rift Valley fever virus nonstructural protein NSs. J. Virol. 75: 1371 – 1377 (2001). >PubMed First description of the interferon-antagonistic function of a nonstructural protein in bunyaviruses. |
|
Kochs, G. & Haller, O.: Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids. Proc Natl Acad Sci USA. 96: 2082-2086 (1999). >PubMed Evidence that human MxA recognizes viral nucleocapsids in living cells. |
|
Arnheiter, H. & Haller, O.: Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon induced Mx proteins. EMBO J. 7: 1315-1320, (1988). >PubMed Demonstration that the antiviral ” intracellular immunity” mediated by the mouse Mx protein can be neutralized by antibodies in living cells. |
|
Stäheli, P., Haller, O., Boll, W., Lindenmann, J. & Weissmann, C.: Mx protein: Constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell. 44: 147-158 (1986). >PubMed Cloning of an interferon-stimulated gene with specific antiviral function with intrinsic antiviral activity. Editors´choice of The Journal of Infectious Diseases: D. R. Spriggs, “Mx Genes, Interferon, and Enlightment”, J.Inf. Dis, 154, 381-382 (1986). |
|
Stäheli, P. & Haller, O.: Interferon-induced human protein with homology to protein Mx of influenza virus resistant mice. Mol Cell Biol. 5: 2150-2153 (1985). >PubMed Description of a human ortholog of mouse Mx. |
|
Horisberger, M.A., Stäheli, P. & Haller, O.: Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus. Proc Natl Acad Sci USA. 80: 1910-1914 (1983). >PubMed Identification of the Mx protein. |
|
Haller, O., Arnheiter, H., Lindenmann, J. & Gresser, I.: Host gene influences sensitivity to interferon action selectively for influenza virus. Nature. 283: 660-662 (1980). >PubMed Demonstration that the antiviral activity of interferon is governed in a virus-specific way by host genes (now called ISGs, for interferon-stimulated genes). |
|
Haller, O., Arnheiter, H., Gresser, I. & Lindenmann, J.: Genetically determined, interferon-dependent resistance to influenza virus in mice. J Exp Med. 149: 601-612 (1979). >PubMed Demonstration that Mx-mediated resistance to influenza viruses depends on interferon. |
|
Haller, O., Hansson, M., Kiessling, R. & Wigzell, H.: Role of non-conventional, natural killer cells in resistance against syngeneic tumor cells in vivo. Nature. 270: 609-611 (1977). >PubMed Evidence for a role of NK cells in suppressing tumor cell growth in vivo. Editorial by R. W. Baldwin “Immune surveillance revisited”, Nature, 270, 557 (1977). |
|
Haller, O., Kiessling, R., Oern, A. & Wigzell, H.: Generation of natural killer cells: An autonomous function of the bone marrow. J Exp Med. 145: 1411-1416 (1977). >PubMed Evidence that Natural Killer (NK) cells originate from bone marrow precursor cells. |
|
Haller, O. & Lindenmann, J.: Athymic (nude) mice express gene for myxovirus resistance. Nature. 250: 679-680 (1974). >PubMed Experimental evidence showing that (i) Mx resistance to influenza virus is intact in the immunocompromised host and that (ii) the IgG response against the viral hemagglutinin depends on T cell help. |
