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The Memory Clinic

Centre for Geriatric Medicine and Gerontology (ZGGF), University of Freiburg, Medical School

The Centre for Geriatric Medicine and Gerontology (ZGGF) comprises consultants from internal medicine, neurology, and psychiatry to provide expert outpatient service for patients with age-associated disorders.

The ZGGF is a centre of excellence for the diagnosis and treatment of memory disorders. The Memory Clinic as part of the ZGGF provides diagnostic services for more than 400 new patients per annum from Germany and abroad. The high-level diagnostic facilities include magnetic resonance imaging (MRI), positron emission tomography (PET) with several tracers including amyloid imaging for Alzheimer’s disease, cerebrospinal fluid (CSF) analysis, and extensive psychological assessment conducted by neuropsychologists.

The centre serves as a clinical core centre of the German Competence Network Dementia (KND) and takes part in the research within the German Competence Network Degenerative Dementias (KNDD) . Several investigator-initiated or industry-funded randomized controlled trials have been successfully performed. For information on ongoing or planned clinical studies, please contact our study manager, Mrs. Iris Natterer (iris.natterer@uniklinik-freiburg.de).

Recent clinical research publications of the ZGGF:

• Metternich B, Schmidtke K, Dykierek P, Hüll M (2008) A pilot group therapy for functional memory disorder. Psychother Psychosom 77(4):259-60.
• Lewczuk P, Kamrowski-Kruck H, Peters O, Heuser I, Jessen F, Popp J, Bürger K, Hampel H, Frölich L, Wolf S, Prinz B, Jahn H, Luckhaus C, Perneczky R, Hüll M, Schröder J, Kessler H, Pantel J, Gertz HJ, Klafki HW, Kölsch H, Reulbach U, Esselmann H, Maler JM, Bibl M, Kornhuber J, Wiltfang J (2008) Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. Mol Psychiatry Jul 29. [Epub ahead of print]
• Schlachetzki JC, Schmidtke K, Beckervordersandforth J, Borozdin W, Wilhelm C, Hüll M, Kohlhase J (2009) Frequency of progranulin mutations in a German cohort of 79 frontotemporal dementia patients. J Neurol Jul 19. [Epub ahead of print]
• Schulte EC, Slawik H, Schüle R, Gunther T, Hüll M (2009) Alterations in excitotoxicity and prostaglandin metabolism in a transgenic mouse model of Alzheimer's disease. Neurochem Int
• Metternich B, Schmidtke K, Hüll M (2009) How are memory complaints in functional memory disorder related to measures of affect, metamemory and cognition? J Psychosom Res 66(5):435-44.
• Blennow K, De Meyer G, Hansson O, Minthon L, Wallin A, Zetterberg H, Lewczuk P, Vanderstichele H, Vanmechelen E, Kornhuber J, Wiltfang J; KND-Study Group, Heuser I, Maier W, Luckhaus C, Rüther E, Hüll M, Jahn H, Gertz HJ, Frölich L, Hampel H, Pernetzki R (2009). Evolution of Abeta42 and Abeta40 levels and Abeta42/Abeta40 ratio in plasma during progression of Alzheimer's disease: a multicenter assessment. J Nutr Health Aging 13(3):205-8.
• Kölsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Teipel SJ, Kornhuber J,Frölich L, Heuser I, Peters O, Wiese B, Kaduszkiewicz H, van den Bussche H, Hüll M, Kurz A, Rüther E, Henn FA, Maier W. (2009) Association of SORL1 gene variants with Alzheimer's disease. Brain Res
• Kornhuber J, Schmidtke K, Frolich L, Perneczky R, Wolf S, Hampel H, Jessen F, Heuser I, Peters O, Weih M, Jahn H, Luckhaus C, Hüll M, Gertz HJ, Schröder J, Pantel J, Rienhoff O, Seuchter SA, Rüther E, Henn F, Maier W, Wiltfang J. (2009) Early and differential diagnosis of dementia and mild cognitive impairment:design and cohort baseline characteristics of the German Dementia Competence Network. Dement Geriatr Cogn Disord
• Metternich B, Schmidtke K, Härter M, Dykierek P, Hüll M (2009) Development and Evaluation of a Group Therapy for Functional Memory and Attention Disorder. Psychother Psychosom Med Psychol
• Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AG, Kauwe JSK, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton A, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature Genetics, Published online: 06 September 2009 | doi:10.1038/ng.440