Titel

Curriculum Vitae (English, PDF)

Prof. Dr. med. Michael Hüll

Psychiater, Psychotherapeut, Geriater
Ärztlicher Leiter des Zentrums für Geriatrie und Gerontologie
Leiter der Sektion Gerontopsychiatrie und Neuropsychologie
International call +49 761 270 - 7094
michael.huell@uniklinik-freiburg.de

Klinische Schwerpunkte

Psychische und neuropsychiatrische Erkrankungen im Alter
Therapeutische Interventionen bei der Alzheimer Demenz

Wissenschaftliche Schwerpunkte

Molekularbiologie und Bildgebung bei kognitiven Störungen
Stresserkrankungen

Ausgewählte Artikel / Selected Articles

Schumann G, Halsband U, Jüngling F, Kassubek J, Gustin S, Heinks T, Hüll M (2000) Combined semantic aphasia and apraxia in a patient with left temporal variant of frontotemporal dementia. Psychiatry Research: Neuroimaging
Fiebich BL, Schleicher S, Spleiss O, Czygan M, Hüll M (2001) Mechanisms of prostaglandin E2-induced IL-6 release in astrocytes: Possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. J Neurochem 79: 950-958
Schmidtke K, Hüll M (2002) Neuropsychological differentiation of small vessel disease, Alzheimer's disease and mixed dementia. J Neurol Sci 203-204:17-22.
Tebartz van Elst LH, Juengling FD, Kassubek J, Schmidtke K, Thiel T, Ebert D, Dykierek P, Hüll M (2002). On the role of quantitative brain imaging in the differential diagnosis of speech disorders. Psych Clin Neurosci 56: 111-115
Fiebich BL, Lieb K, Kammerer N, Hüll M (2003) Synergistic inhibitory effect of ascorbic acid and acetylsalicylic acid on prostaglandin E2 release in primary rat microglia. J Neurochem
Slawik H, Volk B, Fiebich B, Hüll M (2004) Microglial expression of prostaglandin EP3 receptor in excitotoxic lesions in the rat striatum. Neurochem Int
Zahn R, Juengling F, Bubrowski P, Jost E, Dykierek P, Talazko J, Hüll M (2004) Hemispheric asymmetries of hypometabolism associated with semantic memory impairment in Alzheimer's disease: a study using positron emission tomography with fluorodeoxyglucose-F18. Psychiatry Research: Neuroimaging 132:159-72.
Schmidtke K, Hüll M, Talazko J (2005) Posterior cortical atrophy: variant of Alzheimer's disease? A case series with PET findings. J Neurol 25227-35.
Yrjanheikki J, Koistinaho J, Kettunen M, Kauppinen RA, Appel K, Hüll M, Fiebich BL (2005). Long-term protective effect of atorvastatin in permanent focal cerebral ischemia. Brain Res 1052(2):174-9.
Zahn R, Buechert M, Overmans J, Talazko J, Specht K, Ko CW, Thiel T, Kaufmann R, Dykierek P, Juengling F, Hüll M (2005) Mapping of temporal and parietal cortex in progressive nonfluent aphasia and Alzheimer's disease using chemical shift imaging, voxel-based morphometry and positron emission tomography. Psychiatry Res
Hüll M, Muksch B, Akundi RS, Waschbisch A, Hoozemans JJ, Veerhuis R, Fiebich BL (2006) Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes. Neurochem Int 48(8):663-72.
Waschbisch A, Fiebich BL, Akundi RS, Schmitz ML, Hoozemans JJ, Candelario-Jalil E, Virtainen N, Veerhuis R, Slawik H, Yrjanheikki J, Hüll M (2006) Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB. J Neurochem 96(3):680-93.
Jost E, Voigt-Radloff S, Hüll M, Dykierek P, Schmidtke K (2006) Fördergruppe für Demenzpatienten und Beratungsgruppe für Angehörige. Praktikabilität, Akzeptanz und Nutzen eines kombinierten interdisziplinären Behandlungsprogramms. Zeitschrift für Gerontopsychologie und -psychiatrie 19 (3)
Zahn R, Garrard P, Talazko J, Gondan M, Bubrowski P, Juengling F, Slawik H, Dykierek P, Koester B, Hüll M (2006) Patterns of Regional Brain Hypometabolism Associated with Knowledge of Semantic Features and Categories in Alzheimer’s Disease. J Cognitive Neurosci 18 (12): 2138–2151.
Metternich B, Schmidtke K, Dykierek P, Hüll M (2008) A pilot group therapy for functional memory disorder. Psychother Psychosom 77(4):259-60.
Lewczuk P, Kamrowski-Kruck H, Peters O, Heuser I, Jessen F, Popp J, Bürger K, Hampel H, Frölich L, Wolf S, Prinz B, Jahn H, Luckhaus C, Perneczky R, Hüll M, Schröder J, Kessler H, Pantel J, Gertz HJ, Klafki HW, Kölsch H, Reulbach U, Esselmann H, Maler JM, Bibl M, Kornhuber J, Wiltfang J (2008) Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. Mol Psychiatry Jul 29. [Epub ahead of print]
Schlachetzki JC, Schmidtke K, Beckervordersandforth J, Borozdin W, Wilhelm C, Hüll M, Kohlhase J (2009) Frequency of progranulin mutations in a German cohort of 79 frontotemporal dementia patients. J Neurol Jul 19. [Epub ahead of print]
Schulte EC, Slawik H, Schüle R, Gunther T, Hüll M (2009) Alterations in excitotoxicity and prostaglandin metabolism in a transgenic mouse model of Alzheimer's disease. Neurochem Int
Metternich B, Schmidtke K, Hüll M (2009) How are memory complaints in functional memory disorder related to measures of affect, metamemory and cognition? J Psychosom Res 66(5):435-44.
Blennow K, De Meyer G, Hansson O, Minthon L, Wallin A, Zetterberg H, Lewczuk P, Vanderstichele H, Vanmechelen E, Kornhuber J, Wiltfang J; KND-Study Group, Heuser I, Maier W, Luckhaus C, Rüther E, Hüll M, Jahn H, Gertz HJ, Frölich L, Hampel H, Pernetzki R (2009). Evolution of Abeta42 and Abeta40 levels and Abeta42/Abeta40 ratio in plasma during progression of Alzheimer's disease: a multicenter assessment. J Nutr Health Aging 13(3):205-8.
Kölsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Teipel SJ, Kornhuber J,Frölich L, Heuser I, Peters O, Wiese B, Kaduszkiewicz H, van den Bussche H, Hüll M, Kurz A, Rüther E, Henn FA, Maier W. (2009) Association of SORL1 gene variants with Alzheimer's disease. Brain Res
Kornhuber J, Schmidtke K, Frolich L, Perneczky R, Wolf S, Hampel H, Jessen F, Heuser I, Peters O, Weih M, Jahn H, Luckhaus C, Hüll M, Gertz HJ, Schröder J, Pantel J, Rienhoff O, Seuchter SA, Rüther E, Henn F, Maier W, Wiltfang J. (2009) Early and differential diagnosis of dementia and mild cognitive impairment:design and cohort baseline characteristics of the German Dementia Competence Network. Dement Geriatr Cogn Disord
Metternich B, Schmidtke K, Härter M, Dykierek P, Hüll M (2009) Development and Evaluation of a Group Therapy for Functional Memory and Attention Disorder. Psychother Psychosom Med Psychol
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AG, Kauwe JSK, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton A, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature Genetics, Published online: 06 September 2009 | doi:10.1038/ng.440

Übersichtsarbeiten /Reviews

Hüll M, Dykierek P (2000) Demenz und Pflege durch Angehörige - eine Übersicht. Psycho 12:200-205
Hüll M, Lieb K., Fiebich BL, (2000) Anti-inflammatory drugs: a hope for Alzheimer's disease? Exp Op Investigational Drugs 9:671-683.
Hüll M, Schmidtke K (2004) Vaskuläre Demenz, Alzheimer-Demenz oder Mischdemenz? Differentialdiagnose vor dem Hintergrund neuropathologischer Studien. Nervenheilkunde 23:68-122
Schmidtke K, Hüll M (2005) Cerebral small vessel disease: how does it progress? J Neurol Sci 15;229-230:13-20.
Hüll M, Berger M, Heneka M (2006) Disease-Modifying Therapies in Alzheimer’s Disease. Drugs 2006; 66 (16): 2075-2093
Heneka MT, Landreth GE, Hüll M. (2007). Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders. Nature Clin Pract Neurol. 3(9):496-504