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Klinik für Anästhesiologie und Intensivmedizin

Publikationen PD Dr. med. Martin Schick

Schick MA, Burek M, Förster CY, Nagai M, Wunder C, Neuhaus W. Hydroxyethylstarch revisited for acute brain injury treatment.
Neural Regen Res. 2021 Jul;16(7):1372-1376. doi: 10.4103/1673-5374.300978. PMID: 33318420 Review. 

Peter C. Reinacher,, Thomas E. Schlaepfer, Martin A. Schick, Juergen Beck, Hartmut Buerkle, Stefan Schumann. When Resources Are Scarce - Feasibility of Emergency Ventilation of Two Patients With One Ventilator
doi: https://doi.org/10.1101/2020.04.10.20060525 ; Posted April 15, 2020.

Wollborn J, Steiger C, Doostkam S, Schallner N, Schroeter N, Kari FA, Meinel L, Buerkle H, Schick MA, Goebel U. Carbon Monoxide Exerts Functional Neuroprotection After Cardiac Arrest Using Extracorporeal Resuscitation in Pigs.
Crit Care Med. 2020 Feb 24. doi: 10.1097/CCM.0000000000004242. Online ahead of print. PMID: 32102064

Gerhartl A, Hahn K, Neuhoff A, Friedl HP, Förster CY, Wunder C, Schick M, Burek M, Neuhaus W. Hydroxyethylstarch (130/0.4) tightens the blood-brain barrier in vitro.
Brain Res. 2020 Jan 15;1727:146560. doi: 10.1016/j.brainres.2019.146560. Epub 2019 Nov 20. PMID: 31756307


Wollborn J, Steiger C, Ruetten E, Benk C, Kari FA, Wunder C, Meinel L, Buerkle H, Schick MA, Goebel U. Carbon monoxide improves haemodynamics during extracorporeal resuscitation in pigs.
Cardiovasc Res. 2020 Jan 1;116(1):158-170. doi: 10.1093/cvr/cvz075. PMID: 30873524

Wollborn J, Schlueter B, Steiger C, Hermann C, Wunder C, Schmidt J, Diel P, Meinel L, Buerkle H, Goebel U, Schick MAExtracorporeal Resuscitation with Carbon Monoxide Improves Renal Function by Targeting Inflammatory Pathways in Cardiac Arrest in Pigs.
Am J Physiol Renal Physiol. 2019 Sep 4. doi: 10.1152/ajprenal.00241.2019. [Epub ahead of print] PubMed PMID: 31482730.

Wollborn J, Steiger C, Ruetten E, Benk C, Kari FA, Wunder C, Meinel L, Buerkle H, Schick MA, Goebel U. Carbon Monoxide improves Hemodynamics during Extracorporeal Resuscitation in Pigs.
Cardiovasc Res. 2019 Mar 14. pii: cvz075. doi: 10.1093/cvr/cvz075. [Epub ahead of print] PubMed PMID: 30873524.

Wollborn J, Siemering S, Steiger C, Buerkle H, Goebel U, Schick MA. Phosphodiesterase-4 inhibition reduces ECLS-induced vascular permeability and improves microcirculation in a rodent model of extracorporeal resuscitation.
Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H751-H761. doi: 10.1152/ajpheart.00673.2018. Epub 2019 Jan 25. PubMed PMID: 30681364.

Maier S, Goebel U, Krause S, Benk C, Schick MA, Buerkle H, Beyersdorf F, Kari FA, Wollborn J. Somatosensory and transcranial motor evoked potential monitoring in a porcine model for experimental procedures.
PLoS One. 2018 Oct 8;13(10):e0205410. doi: 10.1371/journal.pone.0205410. eCollection 2018. PubMed PMID: 30296297; PubMed Central PMCID: PMC6175523.

Wollborn J, Hermann C, Goebel U, Merget B, Wunder C, Maier S, Schäfer T, Heuler D, Müller-Buschbaum K, Buerkle H, Meinel L, Schick MA, Steiger C. Overcoming safety challenges in CO therapy - Extracorporeal CO delivery under precise feedback control of systemic carboxyhemoglobin levels.
J Control Release. 2018 Jun 10;279:336-344. doi: 10.1016/j.jconrel.2018.04.017. Epub 2018 Apr 12. PubMed PMID: 29655987.

Wollborn J, Ruetten E, Schlueter B, Haberstroh J, Goebel U, Schick MA. Standardized model of porcine resuscitation using a custom-made resuscitation board results in optimal hemodynamic management.
Am J Emerg Med. 2018 Oct;36(10):1738-1744. doi: 10.1016/j.ajem.2018.01.059. Epub 2018 Jan 31. PubMed PMID: 29395757.

Flemming S, Burkard N, Meir M, Schick MA, Germer CT, Schlegel N. Sphingosine-1-Phosphate Receptor-1 Agonist Sew2871 Causes Severe Cardiac Side Effects and Does Not Improve Microvascular Barrier Breakdown in Sepsis.
Shock. 2018 Jan;49(1):71-81. doi: 10.1097/SHK.0000000000000908. PubMed PMID: 28538086.

Wollborn J, Schlegel N, Schick MA. [Phosphodiesterase 4 inhibition for treatment of endothelial barrier and microcirculation disorders in sepsis].
Anaesthesist. 2017 May;66(5):347-352. doi: 10.1007/s00101-017-0305-5. Review. German. PubMed PMID: 28429038.

Rosenbaum C, Schick MA, Wollborn J, Heider A, Scholz CJ, Cecil A, Niesler B, Hirrlinger J, Walles H, Metzger M. Activation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo.
PLoS One. 2016 Mar 10;11(3):e0151335. doi: 10.1371/journal.pone.0151335. eCollection 2016. PubMed PMID: 26964064; PubMed Central PMCID: PMC4786261.

Schick MA, Baar W, Bruno RR, Wollborn J, Held C, Schneider R, Flemming S, Schlegel N, Roewer N, Neuhaus W, Wunder C. Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation.
PLoS One. 2015 Sep 4;10(9):e0137247. doi: 10.1371/journal.pone.0137247. eCollection 2015. PubMed PMID: 26340751; PubMed Central PMCID: PMC4560431.

Schick MA, Baar W, Flemming S, Schlegel N, Wollborn J, Held C, Schneider R, Brock RW, Roewer N, Wunder C. Sepsis-induced acute kidney injury by standardized colon ascendens stent peritonitis in rats - a simple, reproducible animal model.
Intensive Care Med Exp. 2014 Dec;2(1):34. doi: 10.1186/s40635-014-0034-x. Epub 2014 Dec 9. PubMed PMID: 26266931; PubMed Central PMCID: PMC4513002.

Flemming S, Burkard N, Renschler M, Vielmuth F, Meir M, Schick MA, Wunder C, Germer CT, Spindler V, Waschke J, Schlegel N. Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis.
Cardiovasc Res. 2015 Jul 1;107(1):32-44. doi: 10.1093/cvr/cvv144. Epub 2015 May 14. PubMed PMID: 25975259.

Konrad FM, Bury A, Schick MA, Ngamsri KC, Reutershan J. The unrecognized effects of phosphodiesterase 4 on epithelial cells in pulmonary inflammation.
PLoS One. 2015 Apr 24;10(4):e0121725. doi: 10.1371/journal.pone.0121725. eCollection 2015. PubMed PMID: 25909327; PubMed Central PMCID: PMC4409344.

Wollborn J, Wunder C, Stix J, Neuhaus W, Bruno RR, Baar W, Flemming S, Roewer N, Schlegel N, Schick MA. Phosphodiesterase-4 inhibition with rolipram attenuates hepatocellular injury in hyperinflammation in vivo and in vitro without influencing inflammation and HO-1 expression.
J Pharmacol Pharmacother. 2015 Jan-Mar;6(1):13-23. doi: 10.4103/0976-500X.149138. PubMed PMID: 25709347; PubMed Central PMCID: PMC4319242.

Bruno RR, Neuhaus W, Roewer N, Wunder C, Schick MA. Molecular size and origin do not influence the harmful side effects of hydroxyethyl starch on human proximal tubule cells (HK-2) in vitro.
Anesth Analg. 2014 Sep;119(3):570-7. doi: 10.1213/ANE.0000000000000325. PubMed PMID: 25010825.

Flemming S, Schlegel N, Wunder C, Meir M, Baar W, Wollborn J, Roewer N, Germer CT, Schick MA. Phosphodiesterase 4 inhibition dose dependently stabilizes microvascular barrier functions and microcirculation in a rodent model of polymicrobial sepsis.
Shock. 2014 Jun;41(6):537-45. doi: 10.1097/SHK.0000000000000152. PubMed PMID: 24569506.

Schick MA, Isbary JT, Stueber T, Brugger J, Stumpner J, Schlegel N, Roewer N, Eichelbroenner O, Wunder C. Effects of crystalloids and colloids on liver and intestine microcirculation and function in cecal ligation and puncture induced septic rodents.
BMC Gastroenterol. 2012 Dec 17;12:179. doi: 10.1186/1471-230X-12-179. PubMed PMID: 23245375; PubMed Central PMCID: PMC3547783.

Schick MA, Wunder C, Wollborn J, Roewer N, Waschke J, Germer CT, Schlegel N. Phosphodiesterase-4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation.
J Physiol. 2012 Jun 1;590(11):2693-708. doi: 10.1113/jphysiol.2012.232116. Epub 2012 Apr 10. PubMed PMID: 22495586; PubMed Central PMCID: PMC3424725.

Betz B, Schneider R, Kress T, Schick MA, Wanner C, Sauvant C. Rosiglitazone affects nitric oxide synthases and improves renal outcome in a rat model of severe ischemia/reperfusion injury.
PPAR Res. 2012;2012:219319. doi: 10.1155/2012/219319. Epub 2012 Feb 15. PubMed PMID: 22448163; PubMed Central PMCID: PMC3289925.

Stumpner J, Smul TM, Redel A, Hilz T, Tischer-Zeitz T, Eisenbarth H, Schick MA, Kehl F, Roewer N, Lange M. Desflurane-induced and ischaemic postconditioning against myocardial infarction are mediated by Pim-1 kinase.
Acta Anaesthesiol Scand. 2012 Aug;56(7):904-13. doi: 10.1111/j.1399-6576.2012.02657.x. Epub 2012 Mar 5. PubMed PMID: 22385356.

Neuhaus W, Schick MA, Bruno RR, Schneiker B, Förster CY, Roewer N, Wunder C. The effects of colloid solutions on renal proximal tubular cells in vitro.
Anesth Analg. 2012 Feb;114(2):371-4. doi: 10.1213/ANE.0b013e3182367a54. Epub 2011 Oct 24. PubMed PMID: 22025492.

Brugger J, Schick MA, Brock RW, Baumann A, Muellenbach RM, Roewer N, Wunder C. Carbon monoxide has antioxidative properties in the liver involving p38 MAP kinase pathway in a murine model of systemic inflammation.
Microcirculation. 2010 Oct;17(7):504-13. doi: 10.1111/j.1549-8719.2010.00044.x. PubMed PMID: 21040116.

Schick MA, Isbary TJ, Schlegel N, Brugger J, Waschke J, Muellenbach R, Roewer N, Wunder C. The impact of crystalloid and colloid infusion on the kidney in rodent sepsis.
Intensive Care Med. 2010 Mar;36(3):541-8. doi: 10.1007/s00134-009-1704-0. Epub 2009 Nov 5. PubMed PMID: 19890625.

Witte MB, Barbul A, Schick MA, Vogt N, Becker HD. Upregulation of arginase expression in wound-derived fibroblasts.
J Surg Res. 2002 Jun 1;105(1):35-42. PubMed PMID: 12069499.


Klinik für Anästhesiologie
und Intensivmedizin
Universitätsklinikum Freiburg

Hugstetter Strasse 55
79106 Freiburg

PD Dr. med. Martin Schick

Leiter der AG "Organprotektion und Inflammation"

Facharzt für Anästhesiologie
Spezielle Intensivmedizin

Telefon 0761/270-29580
Telefax 0761 270-23960
E-Mail martin.schick@uniklinik-freiburg.de