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Tumorzentrum Freiburg - CCCF

Lena Hölzen, M.Sc.

Institute of Molecular Medicine and Cell Research, Medical Faculty, Albert-Ludwigs-University Freiburg, D79104   Freiburg, Germany

Faculty of Biology, Albert-Ludwigs-University Freiburg, D79104 Freiburg, Germany

German Cancer Research Center (DKFZ), D69102 Heidelberg, Germany

German Cancer Consortium (DKTK), partner site Freiburg, D79106 Freiburg, Germany





Project: Degradome-wide genetic interference screening in murine breast cancer cells

In my PhD-project I am employing a degradome-wide inducible high-throughput genetic RNAi-based protease knockdown screes in two murine breast cancer cells lines to functionally analyze the role of proteases in breast cancer. Furthermore, I am investigating the functional connectivity between proteases and the highly cancer-associated PI3K-pathway using synthetic lethality screens.

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