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Tumorzentrum Freiburg - CCCF

Christoph Müller, M. Sc.

Department of Radiology and Radiotherapy at the University Medical Center Freiburg

German cancer research center (DKFZ).

Project: Carbon-13 MR spectroscopic imaging of hyperpolarized tracers with advanced acquisition strategies

Next to chemical shift imaging (CSI) and echo planar spectroscopic imaging (EPSI), steady state imaging methods can also be utilized to access a spectral resolution by implementing multiple readouts with short time differences within one echo. In that manner such sequences (SSFP, CPMG) combined with multi-echo readout promise most efficient acquisition of the transient signal of hyperpolarized tracers, especially when large fields of view or 3D volumes are to be imaged.



  • Christoph A. Müller, Christian Hundshammer, Miriam Braeuer, Jason G. Skinner, Stephan Berner, Jochen Leupold, Stephan Düwel, Stephan G. Nekolla, Sven Månsson, Adam E. Hansen, Dominik von Elverfeldt, Jan H. Ardenkjaer‐Larsen, Franz Schilling, Markus Schwaiger, Jürgen Hennig, Jan‐Bernd Hövener, Dynamic 2D and 3D mapping of hyperpolarized pyruvate to lactate conversion in vivo with efficient multi‐echo balanced steady‐state free precession at 3 T, NMR in Biomedicine. 2020;33:e4291
  • Hundshammer C, Düwel S, Ruseckas D, et al. Hyperpolarized Amino Acid Derivatives as Multivalent Magnetic Resonance pH Sensor Molecules. Sensors. 2018;18(2):600. doi:10.3390/s18020600
  • Hundshammer C, Braeuer M, Müller CA, et al. Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13C-MRSI. Theranostics. 2018;8(17):4765-4780. doi:10.7150/thno.25162
  • Schmidt AB, Berner S, Schimpf W, et al. Liquid-state carbon-13 hyperpolarization generated in an MRI system for fast imaging. Nature Communications. 2017;8:14535. doi:10.1038/ncomms14535
  • Jung B, Müller C, Buchenberg W, et al. Investigation of hemodynamics in an in vitro system simulating left ventricular support through the right subclavian artery using 4-dimensional flow magnetic resonance imaging. The Journal of Thoracic and Cardiovascular Surgery. 2015. doi:10.1016/j.jtcvs.2015.02.048

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