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Tumorzentrum Freiburg - CCCF

Özen, Ali Gaglar, Dr. - Ing.

Department of Radiology and Radiotherapy at the University Medical Center Freiburg

German Cancer Consortium (DKTK), partner site Freiburg

Projects:

17O MRI for Regional CMRO2 Mapping; Development of Actively Visualized Devices and Safety of MRI-guided Interventions

MR Imaging with nuclei other than 1H provide additional information about tissue metabolism. MRI with the stable isotope 17O is used to quantify tissue oxygenation e.g. to optimize the treatment strategy in brain tumors. We develop dedicated imaging pulse sequences, novel reconstruction methods and radio frequency hardware to translate 17O MRI to clinical routine.

MRI provides soft tissue contrast superior to x-ray technology and ultrasound. Therefore, MRI-guided operations such as biopsy, therapy, cardiovascular catheterization using active and passive devices such as metallic needles, metallic guidewires, electrodes, and active catheters becoming increasingly popular. We work on increasing the MRI visibility of interventional devices, assess the safety of those devices under MRI, and develop novel methods to investigate and eliminate potential safety risks.

Publications:

Journal Articles (3 of 8)

    Kurzhunov D, et al., Özen AC and Bock M. (2018) DIrect EStimation of 17O MR ImageS (DIESIS) for Quantification of Oxygen Metabolism in the Human Brain with Partial Volume Correction. Magn Reson Med. In print.

    Heidt T, Reiss S, Krafft A, Özen AC, et al. (2017) MR-guided coronary catheterization at 3 tesla: Feasibility and initial results from a minipig study. European Heart Journal, 38(1):ehx501.P546   

    Kurzhunov D, et al., Özen AC and Bock M. (2017) 3D CMRO2 mapping in human brain with direct 17O MRI: comparison of conventional and proton-constrained reconstructions. Neuroimage 155:612-624.

    Dadakova T, Krafft A, Özen AC, Bock M. (2018) Optimization of Acoustic Radiation Force Imaging: Influence of Timing Parameters on Sensitivity. Magn Reson Med. 79(2):981-986.      

    Traser L, Özen AC, et al. (2017) Respiratory dynamics in phonation and breathing-A real-time MRI study  Respiratory Physiology & Neurobiology 236:69-77.

    Özen AC, Traser L, Echternach M, Dadakova T, Burdumy M, Richter B and Bock M. (2016), Ensuring safety and functionality of electroglottography measurements during dynamic pulmonary MRI. Magn. Reson. Med. 76:1629–1635.

    Özen AC, Bock M, Atalar E. (2015) Active decoupling of RF coils using a transmit array system. Magnetic Resonance Materials in Physics, Biology and Medicine 28(6):565-576.

    Özen AC, Ludwig U, Öhrström LM, Rühli FJ and Bock M. (2016), Comparison of ultrashort echo time sequences for MRI of an ancient mummified human hand. Magn. Reson. Med. 75:701–708.

Book Chapters

    Özen AC, Algin O, Atalar E (2015). Manyetik Rezonans Görüntüleme Fiziği. In I.T. Sancaklı (Ed), Temel Radyoloji (97-124). Ankara, Turkey: Ayrıntı.

Conference Papers

    Özen AC, Akin B, Bock M (2018) Safety of Active Catheters in MRI: Termination Impedance vs. RF-induced Heating. In: Proceedings of the 26th scientific meeting, International Society for Magnetic Resonance in Medicine, Paris, France. p 4429

    Özen AC, Akin B, Bock M (2018) Concurrent Excitation and Acquisition for the Ultimate MRI Experience: Silent, Implant Friendly, Nearly 100% Efficient. In: Proceedings of the 26th scientific meeting, International Society for Magnetic Resonance in Medicine, Paris, France. p 4429

    Reiss S, Heidt T, Lottner T, Özen AC, et al. (2018) Fully MR-Guided Implantation of a Bioresorbable Scaffold in the Left Coronary Artery of a Pig at 3T. In: Proceedings of the 26th scientific meeting, International Society for Magnetic Resonance in Medicine, Paris, France. p 601

    Fischer J, Abels T, Özen AC, et al. (2018) Highspeed Imaging with Sub-millisecond Temporal Resolution of the Vocal Folds Oscillations using EGG-Gated Gradient Echo with Rapid Phase Encoding. In: Proceedings of the 26th scientific meeting, International Society for Magnetic Resonance in Medicine, Paris, France. p 383

    Reiss S, Lottner T, Özen AC, et al. (2018) Electro-Optic E-field Mapping of Medical Implants with High Spatial Resolution: Resonant Excitation of Metallic Stents. In: Proceedings of the 26th scientific meeting, International Society for Magnetic Resonance in Medicine, Paris, France. p 1474

    Lottner T, Reiss S, Özen AC, et al. (2018) Validating and Measuring Transfer Functions of Straight Wires using a Combination of an Electro-optic Field Sensor and Simulation. In: Proceedings of the 26th scientific meeting, International Society for Magnetic Resonance in Medicine, Paris, France. p 642

    Kurzhunov D, et al., Özen AC, Bock M. (2018) Quantification of Oxygen Metabolism in Human Brain: Comparison of Direct 17O with Indirect 1H MR Method. In: Proceedings of the 26th scientific meeting, International Society for Magnetic Resonance in Medicine, Paris, France. p 3689

    Agazi T, Fischer J, Özen AC, et al. (2018) Effects of Reduced Dead Times on the SNR of Tissue with Short T2* values. In: Proceedings of the 26th scientific meeting, International Society for Magnetic Resonance in Medicine, Paris, France. p 5193

    Özen AC, Lottner T, Reiss S, Krafft A, Heidt T, von zur Muhlen C, Bock M (2017) Operator Controlled Illumination of Active Catheter Tips Using a Variable Attenuator. In: Proceedings of the 25th scientific meeting, International Society for Magnetic Resonance in Medicine, Honolulu, Hawai'i. p 741

    Özen AC, Korvink J, Atalar E, Bock M (2017) In Vivo MRI with Concurrent Excitation and Acquisition Using Dynamic Analog Cancellation with Real-Time Feedback. In: Proceedings of the 25th scientific meeting, International Society for Magnetic Resonance in Medicine, Honolulu, Hawai'i. p 1047

    Özen AC, Jouda M, Korvink J, Bock M (2017) Full Digital Cancellation-Based NMR with Concurrent Excitation and Acquisition Using a Lock-In Amplifier. In: Proceedings of the 25th scientific meeting, International Society for Magnetic Resonance in Medicine, Honolulu, Hawai'i. p 5593

    Reiss S, Özen AC, Lottner T, Heidt T, Krafft A, Besch L, Klaus D, von zur Muhlen C, Bock M (2017) Active Catheter Tracking for MR-Guided Percutaneous Coronary Intervention at 3T: Initial Results in a Pig Model. In: Proceedings of the 25th scientific meeting, International Society for Magnetic Resonance in Medicine, Honolulu, Hawai'i. p 2611

    Lottner T, Özen AC, Reiss S, Heidt T, Krafft A, Besch L, Klaus D, von zur Muhlen C, Bock M (2017) Of Active Catheters and Guidewires: How Do Guidewires Affect the Tracking Signal Intensity? In: Proceedings of the 25th scientific meeting, International Society for Magnetic Resonance in Medicine, Honolulu, Hawai'i. p 5560

    Fischer J, Özen AC, Kurzhunov D, Marco R, Tesfai A, Ruhli F, Ludwig U, Bock M (2017) Cross-Modality MR Image Reconstruction: CT-Constrained Anisotropic Diffusion to Preserve Edge Information in MRI of an Ancient Mummified Hand. In: Proceedings of the 25th scientific meeting, International Society for Magnetic Resonance in Medicine, Honolulu, Hawai'i. p 1351

    Kurzhunov D, Borowiak R, Marco R, Krafft A, Özen AC, Bock M (2017) CMRO2 Quantification in Human Brain with Direct 17O-MRI: Profile Likelihood Analysis for Optimization of Temporal Resolution. In: Proceedings of the 25th scientific meeting, International Society for Magnetic Resonance in Medicine, Honolulu, Hawai'i. p 568

    Kurzhunov D, Borowiak R, Özen AC, Bock M (2017) 3D CMRO2 Mapping in Human Brain with Direct 17O-MRI: Comparison of Methods for Image Reconstruction and Partial Volume Correction. In: Proceedings of the 25th scientific meeting, International Society for Magnetic Resonance in Medicine, Honolulu, Hawai'i. p 3602

    Tesfai A, Fischer J, Özen AC, Bock M (2017) Comparison of Different RF Coil Designs for Short T2* Samples. In: Proceedings of the 25th scientific meeting, International Society for Magnetic Resonance in Medicine, Honolulu, Hawai'i. p 4300 

    Özen AC, Korvink J, Atalar E, Bock M (2016) In Vivo Concurrent Excitation and Acquisition MRI with Self-Referenced Active Decoupling. In: Proceedings of the 24th scientific meeting, International Society for Magnetic Resonance in Medicine, Singapore. p 2179

    Özen AC, Korvink J, Bock M  (2016) Concurrent Excitation and Acquisition in Steady State: T1-Modulation Effects of Frequency Sweep. In: Proceedings of the 24th scientific meeting, International Society for Magnetic Resonance in Medicine, Singapore. p 1809

    Salim M, Ozen AC, Bock M, Atalar E (2016) Detection of Mr Signal During Rf Excitation Using Full Duplex Radio System. In: Proceedings of the 24th scientific meeting, International Society for Magnetic Resonance in Medicine, Singapore. p 3636

    Dadakova T, Özen AC, Krafft A, Korvink J, Bock M (2016) Phase Artifact Correction for Improved ARFI Displacement Mapping Using a Short FID Navigator. In: Proceedings of the 24th scientific meeting, International Society for Magnetic Resonance in Medicine, Singapore. p 3611

    Özen AC, et al. (2015) Active Decoupling of RF Coils: Application to 3D MRI with Concurrent Excitation and Acquisition. In: Proceedings of the 32nd ESMRMB Anual Meeting, Edinburgh, UK.

    Özen AC, et al. (2015) Which Technique is Best? Optimizing MRI of an Ancient Mummified Human Hand. In: Proceedings of the Evolutionary Medicine Conference, Zurich, Switzerland.

    Özen AC, et al.  (2015) Ensuring Safety and Functionality of Electroglottography Measurements During Lung MRI. In: Proceedings of the 23rd scientific meeting, International Society for Magnetic Resonance in Medicine,Toronto, Canada.

    Özen AC, et al. (2015) Active Decoupling of RF Coils: Application to 3D MRI with Concurrent Excitation and Acquisition. In: Proceedings of the 23rd scientific meeting, International Society for Magnetic Resonance in Medicine,Toronto, Canada.

    Dadakova T, et al. (2015) MR-ARFI for the Quantification of Tissue Elastic Properties. In: Proceedings of the 23rd scientific meeting, International Society for Magnetic Resonance in Medicine,Toronto, Canada.

    Özen AC, et al. (2014) Comparison of three ultrashort echo time sequences in MRI of an ancient Mummified hand. In: Proceedings of the DGMP Annual Meeting, Zurich, Switzerland

    Özen AC, et al.  (2014) Comparison of UTE, PETRA and SPI sequences in MRI of Ancient Remains. In: Proceedings of the 22nd scientific meeting, International Society for Magnetic Resonance in Medicine, Milano, Italy.

    Özen AC, et al.  (2014) "Be nice to your gradients!" Useful gradient modifications for SPI. In: Proceedings of the 22nd scientific meeting, International Society for Magnetic Resonance in Medicine, Milano, Italy.

    Ludwig U, et al.  (2014) ZTE MRI enables imaging of Egyptian Mummy: A comparison to CT and THz imaging. In: Proceedings of the 22nd scientific meeting, International Society for Magnetic Resonance in Medicine, Milano, Italy.

    Pavlina JM, et al.  (2014) Conductivity Effects on RF Surface Coils used for MR-Guided HIFU of the Prostate. In: Proceedings of the 22nd scientific meeting, International Society for Magnetic Resonance in Medicine, Milano, Italy.

    Demir T, et al.  (2014) Cylindrical Encoding in MRI. In: Proceedings of the 22nd scientific meeting, International Society for Magnetic Resonance in Medicine, Milano, Italy.

    Özen AC, et al.  (2013) Decoupling of Radio Frequency Coils using a Transmit Array System: Application to Magnetic Rezonans Imaging with Concurrent Excitation and Acquisition (CEA) and Ultra-short Echo-time Imaging (UTE). In: Proceedings of the 21st scientific meeting, International Society for Magnetic Resonance in Medicine, SLC, UTAH, USA.

    Acikel V, et al.  (2013) A Novel MRI Based Electrical Properties Measurement Technique. In: Proceedings of the 21st scientific meeting, International Society for Magnetic Resonance in Medicine, SLC, UTAH, USA.

    Özen AC, et al.  (2012) Detection of MRI Signal During Transmission Using a Transmit Array System. In: Proceedings of the 20th scientific meeting, International Society for Magnetic Resonance in Medicine, Melbourne, Australia.

    Özen AC, et al.  (2011) A practical measurement technique and setup for determination of electromagnetic properties of MRI phantoms. In: Proceedings of the Turkish Magnetic Resonance Society annual meeting, Istanbul, Turkey.

 

 

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