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Tumorzentrum Freiburg - CCCF

Florian Scherer, MD

Department of Hematology, Oncology, and Stem Cell Transplantation, University Medical Center Freiburg

Project

My research interests are focused on developing non-invasive biomarkers (Liquid Biopsy) that help improve the clinical management of cancer patients and understand biological factors driving hematological and solid malignancies. In our current project, we aim to characterize the role of circulating tumor DNA for non-invasive tumor genotyping and disease monitoring in patients with brain cancers.

Peer-reviewed articles (First or last author)

* Equal contribution

  • Lauer EM, Waterhouse M, Braig M, Mutter J, Bleul S, Duque-Afonso J, Duyster J, Marks R, Reinacher PC, Prinz M, Illerhaus G, Finke J, Schorb E, and Scherer F. Ibrutinib in patients with relapsed/refractory central nervous system lymphoma: a retrospective single center analysis. British Journal of Haematology. 2020. IF: 5.2
  • Kurtz DM*, Esfahani MS*, Scherer F*, Soo J, Jin MC, Liu CL, Newman AM, Dührsen U, Hüttmann A, Casasnovas O, Westin JR, Ritgen M, Böttcher S, Langerak AW, Roschewski M, Wilson WH, Gaidano G, Rossi D, Bahlo J, Hallek M, Tibshirani R, Diehn M, and Alizadeh AA. Dynamic risk profiling using serial tumor biomarkers for personalized outcome prediction. Cell. 2019. IF: 36.2
  • Kurtz DM*, Scherer F*, Jin MC, Soo, J, Craig AFM, Esfahani MS, Chabon JJ, Stehr H, Liu CL, Tibshirani R, Maeda LS, Gupta NK, Khodadoust MS, Advani RH, Levy R, Newman AM, Dührsen U, Hüttmann A, Meignan M, Casasnovas O, Westin JR, Roschewski M, Wilson WH, Gaidano G, Rossi D, Diehn M, and Alizadeh AA. Circulating tumor DNA measurements as early outcome predictors in diffuse large B-cell lymphoma. Journal of Clinical Oncology. 2018. IF: 26.3
  • Scherer F*, Kurtz DM*, Newman AM*, Stehr H, Craig AFM, Esfahani MS, Lovejoy AF, Chabon JJ, Klass DM, Liu CL, Zhou L, Glover, C, Visser BC, Poultsides GA, Advani RH, Maeda LS, Gupta NK, Levy R, Ohgami RS, Kunder CA, Diehn M, and Alizadeh AA. Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA. Science Translational Medicine. 2016. IF: 16.8
  • Scherer F, van der Burgt M, Kiełbasa SM, Bertinetti-Lapatki C, Dühren von Minden M, Mikesch K, Zirlik K, Wreede L, Veelken H, and Navarrete MA. Selection patterns of B-cell receptors and the natural history of follicular lymphoma. British Journal of Haematology. 2016. IF: 5.7
  • Scherer F, Navarrete MA, Bertinetti-Lapatki C, Boehm J, Schmitt-Graeff A, and Veelken H. Isotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutation. Leukemia and Lymphoma. 2016. IF: 2.8

Peer-reviewed articles (Co-author)

* Equal contribution

  • Hussung S, Follo M, Klar RFU, Michalczyk S, Fritsch K, Nollmann F, Hipp J, Duyster J, Scherer F, von Bubnoff N, Boerries M, Wittel U, and Fritsch RM. Development and clinical validation of discriminatory multi-target digital droplet PCR assays for the detection of hot spot KRAS and NRAS mutations in cell-free DNA. Journal of Molecular Diagnostics. 2020. IF: 4.4
  • O’Connor T, Zhou X, Kosla J, Adili A, Beccaria MG, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, Förster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, Höpken Ü, Knolle PA, von Baumgarten L, Keller U, and Heikenwalder M. Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention. Cancer Cell. 2019. IF: 22.8
  • Newman AM, Steen CB, Liu CL, Gentles AJ, Chaudhuri AA, Scherer F, Khodadoust MS, Esfahani MS, Luca BA, Steiner D, Diehn M, and Alizadeh AA. Determining cell type abundance and expression from bulk tissues with digital cytometry. Nature Biotechnology. 2019. IF: 35.7
  • Chaudhuri AA, Chabon JJ, Lovejoy AF, Newman AM, Stehr H, Azad TD, Khodadoust MS, Esfahani MS, Liu CL, Zhou L, Scherer F, Kurtz DM, Say C, Carter JN, Merriott DJ, Dudley JC, Binkley MS, Modlin L, Padda SK, Gensheimer MF, West RB, Shrager JB, Neal JW, Wakelee HA, Loo BW, Alizadeh AA, and Diehn M. Early detection of molecular residual disease in localized lung cancer by circulating tumor DNA profiling. Cancer Discovery. 2017. IF: 24.4
  • Newman AM*, Lovejoy AF*, Klass DM*, Kurtz DM, Chabon JJ, Scherer F, Stehr H, Liu CL, Bratman SV, Say C, Zhou L, Carter JN, West RB, Sledge Jr GW, Shrager JB, Loo Jr BW, Neal JW, Wakelee HA, Diehn M, and Alizadeh AA. Integrated digital error suppression for improved detection of circulating tumor DNA. Nature Biotechnology. 2016. IF: 41.7
  • Chabon JJ, Simmons AD, Lovejoy AF, Esfahani MS, Newman AM, Haringsma HJ, Kurtz DM, Stehr H, Scherer F, Karlovich CA, Harding TC, Durkin KA, Otterson GA, Purcell WT, Camidge DR, Goldman JW, Sequist LV, Piotrowska Z, Wakelee HA, Neal JW, Alizadeh AA, and Diehn M. Circulating tumor DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients. Nature Communications. 2016. IF: 12.1
  • Duque-Afonso J, Feng J, Scherer F, Lin C-H, Wong SHK, Wang Z, Iwasaki M, and Cleary ML. Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. Journal of Clinical Investigation. 2015. IF: 12.6
  • Karmakar S, Harcourt EM, Hewings DS*, Scherer F, Lovejoy AF, Kurtz DM, Ehrenschwender T, Barandun LJ, Roost C, Alizadeh AA, and Kool ET. Organocatalytic removal of formaldehyde adducts from RNA and DNA bases. Nature Chemistry. 2015. IF: 27.9
  • Kurtz DM, Green MR, Bratman SV, Scherer F, Liu CL, Kunder CA, Takahashi K, Glover C, Keane C, Kihira S, Visser B, Callahan J, Kong KA, Faham M, Corbelli KS, Miklos D, Advani RH, Levy R, Hicks RJ, Hertzberg M, Ohgami RS, Gandhi MK, Diehn M, and Alizadeh AA. Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing. Blood. 2015. IF: 11.8

Reviews

* Equal contribution

  • Scherer F. Capturing tumor heterogeneity and clonal evolution by circulating tumor DNA profiling. Recent Results Cancer Research. 2020.
  • Scherer F*, Kurtz DM*, Diehn M, and Alizadeh AA. High-throughput sequencing for noninvasive disease detection in hematologic malignancies. Blood. 2017. IF: 15.1

A complete publication list can also be found here

 

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