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Centrum für Chronische Immundefizienz - CCI

Research Areas

  1. Immunological control of streptococci and staphylococci as harmless colonizers at mucocutaneous sites (skin, intestine). Impact of individual development on this control. This work involves animal models, where progression from bacterial colonization to invasion can be studied and manipulated, analysis of bacterial isolates from patients, etc.
  2. Cell autonomous interaction and signaling events between macrophages, monocytes and granulocytes and bacteria. Areas of interest are receptor-effector interactions, cellular programming and handling of bacteria. Reporter assays, confocal microscopy and live cell imaging are critical tools.
  3. Development and differentiation of macrophage subsets in vivo. We are particularly interested in postnatal development of macrophage that reside close to colonizing bacteria. We use reporter mice, conditional mice and stem-cell derived macrophages.

Main Methods

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Collaborations

  • Macrophage biology: Marco Prinz (Freiburg), Michael Sieweke (Marseille)
  • Novel immunodeficiencies: Klaus Schwarz (Ulm)
  • Pneumococcal pathogenesis: Richard Malley (Boston, MA, USA)
  • Stem cells: Toni Cathomen (Freiburg)
  • Streptococcal genetics and pathogenesis: Claire Poyart and Patrick Trieu-Cuot (Paris)
  • Toll-like receptors, inflammasome: Douglas Golenbock (Worcester, MA, USA), Carsten Kirschning (Essen)
  • Cellular innate immunity to staphylococci: Andreas Peschel (Tübingen), Jos van Strijp (Utrecht)

Research Sponsors

  • Deutsche Forschungsgemeinschaft (DFG)
  • National Institutes of Health (Bethesda, ML, USA)
  • European Society of Pediatric Infectious Diseases (ESPID)
  • Bundesministerium für Bildung und Forschung (BMBF)
  • Landesstiftung Baden-Württemberg
Contact

Prof. Dr. med. Philipp Henneke

MEDICAL CENTER - UNIVERSITY OF FREIBURG
Center for Chronic Immunodeficiency
at Center for Translational Cell Research

Breisacher Str. 115
79106 Freiburg
Germany

Phone: +49 (0)761 270-77640 (Secretary)
Fax: +49 (0)761 270-77600
philipp.henneke@uniklinik-freiburg.de