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Klinik für Allgemein- und Viszeralchirurgie

Dr. Birte Kulemann

Fachärztin für Viszeralchirurgie

Ausbildung:

  • 2001 Abitur am Gymnasium Oberalster, Hamburg
  • 2001-2008 Medzinstudium in Kiel, Freiburg, Los Angeles and Buenos Aires
  • 2/2009 – 12/2010 Assistenzärztin in der Abteilung Allgemein- und Viszeralchirirugie der Chirurgischen Universitätsklinik Freiburg
  • 1/2011-12/2011 Surgical Research Fellowship an der MGH, Harvard Medical School, Boston (Pancreatic Biology Research Laboratory, Sarah P Thayer M.D. , PhD. and Andrew L Warsahw M.D.)
  • 1/2012-5/2015 Wissenschaftliche Mitarbeiterin in der Abteilung Allgemein- und Viszeralchirurgie der Chirurgischen Universitätsklinik Freiburg
  • 5/2015-3/2016 Mutterschutz und Elternzeit
  • Seit 4/2016 Wissenschaftliche Mitarbeiterin in der Klinik für Allgemein- und Viszeralchirurgie der Chirurgischen Universitätsklinik Freiburg
  • 6/2017 Fachärztin für Viszeralchirurgie und Beantragung der venia legendi

Promotion:

  • 2009 bei PD Dr. A. Clad, Universitätsfrauenklinik Freiburg: "Chlamydia trachomatis - a prevalence study in 2794 women in childbed" (magna cum laude).

Preis:

  • 2017 Ludwig-Rehn-Preis der Mittelrheinischen Chirurgenvereinigung
  • 2017 FamSurg Preis der Firma Storz

Eingeworbene Drittmittel:

  • Comprehensive Cancer Center Freiburg (CCCF), Förderprogramm: „Frühe Klinische Studien", 45.500€

Interessensschwerpunkte:

  • Pankreaskarzinom
  • Zirkulierende Tumorzellen
  • Intestinale Anastomoseneheilung

 

Publikationen (Stand 10/2017):

  1. Hoeppner J, Kulemann B. Circulating Tumor Cells in Esophageal Cancer. Oncol Res Treat. 2017;40(7-8):417-422.  
  2. Kulemann B, Rösch S, Seifert S, Timme S, Bronsert P, Seifert G, Martini V, Kuvendjiska J, Glatz T, Hussung S, Fritsch R, Becker H, Pitman MB, Hoeppner J. Pancreatic cancer: Circulating Tumor Cells and Primary Tumors show Heterogeneous KRAS Mutations. Sci Rep. 2017 Jul 3;7(1):4510. doi: 10.1038/s41598-017-04601-z. PubMed PMID: 28674438; PubMed Central PMCID: PMC5495768.
  3. Enderle-Ammour K, Bader M, Ahrens TD, Franke K, Timme S, Csanadi A, Hoeppner J, Kulemann B, Maurer J, Reiss P, Schilling O, Keck T, Brabletz T, Stickeler E, Werner M, Wellner UF, Bronsert P. Form follows function: Morphological and immunohistological insights into epithelial-mesenchymal transition characteristics of tumor buds. Tumour Biol. 2017 May;39(5):1010428317705501.  
  4. Kulemann B, Hoeppner J. Extended pancreatic head resection for pancreatic cancer in the presence of a circumportal pancreas. ANZ J Surg. 2017 Mar 30.  
  5. Fuellgraf H, Schilling O, Lai ZW, Kulemann B, Timme S, Makowiec F, Shahinian JH, Hoeppner J, Werner M, Hopt UT, Wellner UF, Bronsert P. The Prognostic Impact of the Carcinoembryonic Antigen in Ampullary Cancer - A Retrospective Single Center Study. J Cancer. 2017 Feb 25;8(4):657-664. doi: 10.7150/jca.16200. eCollection 2017. PubMed PMID: 28367245; PubMed Central PMCID: PMC5370509.  
  6. Kulemann B, Fritz M, Glatz T, Marjanovic G, Sick O, Hopt UT, Hoeppner J, Makowiec F. Complications after pancreaticoduodenectomy are associated with higher amounts of intra- and postoperative fluid therapy: A single center retrospective cohort study. Ann Med Surg (Lond). 2017 Feb 27;16:23-29.  
  7. Rosenbaum MW, Cauley CE, Kulemann B, Liss AS, Castillo CF, Warshaw AL, Lillemoe KD, Thayer SP, Pitman MB. Cytologic characteristics of circulating epithelioid cells in pancreatic disease. Cancer. 2017 May;125(5):332-340.  
  8. Glatz T, Kulemann B, Marjanovic G, Bregenzer S, Makowiec F, Hoeppner J. Postoperative fluid overload is a risk factor for adverse surgical outcome in patients undergoing esophagectomy for esophageal cancer: a retrospective study in 335 patients. BMC Surg. 2017 Jan 13;17(1):6.  
  9. Glatz T, Marjanovic G, Kulemann B, Sick O, Hopt UT, Hoeppner J. Hybrid minimally invasive esophagectomy vs. open esophagectomy: a matched case analysis in 120 patients. Langenbecks Arch Surg. 2017 Mar;402(2):323-331.  
  10. Shahinian JH, Fuellgraf H, Tholen S, Mastroianni J, Knopf JD, Kuehs M, Mayer B, Schlimpert M, Kulemann B, Kuesters S, Hoeppner J, Wellner UF, Werner M, Hopt UT, Zeiser R, Bronsert P, Schilling O. Pregnancy Specific β-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival. J Cancer. 2016 Oct 17;7(14):2018-2027.  
  11. Glatz T, Marjanovic G, Kulemann B, Hipp J, Theodor Hopt U, Fischer A, Richter-Schrag HJ, Hoeppner J. Management and outcome of esophageal stenting for spontaneous esophageal perforations. Dis Esophagus. 2017 Feb 1;30(3):1-6.  
  12. Riediger H, Kulemann B, Wittel U, Adam U, Sick O, Neeff H, Höppner J, Hopt UT, Makowiec F. Prognostic Role of Log Odds of Lymph Nodes After Resection of Pancreatic Head Cancer. J Gastrointest Surg. 2016 Oct;20(10):1707-15.  
  13. Wellner UF, Krauss T, Csanadi A, Lapshyn H, Bolm L, Timme S, Kulemann B, Hoeppner J, Kuesters S, Seifert G, Bausch D, Schilling O, Vashist YK, Bruckner T, Langer M, Makowiec F, Hopt UT, Werner M, Keck T, Bronsert P. Mesopancreatic Stromal Clearance Defines Curative Resection of Pancreatic Head Cancer and Can Be Predicted Preoperatively by Radiologic Parameters: A Retrospective Study. Medicine (Baltimore). 2016 Jan;95(3):e2529.  
  14. Kulemann B, Liss AS, Warshaw AL, Seifert S, Bronsert P, Glatz T, Pitman MB, Hoeppner J. KRAS mutations in pancreatic circulating tumor cells: a pilot study. Tumour Biol. 2016 Jun;37(6):7547-54. 
  15. Glatz T, Lederer AK, Kulemann B, Seifert G, Holzner PA, Hopt UT, Hoeppner J, Marjanovic G. The degree of local inflammatory response after colonic resection depends on the surgical approach: an observational study in 61 patients. BMC Surg. 2015 Oct 6;15:108.  
  16. Glatz T, Bronsert P, Schäfer M, Kulemann B, Marjanovic G, Sick O, Hopt UT, Zirlik K, Makowiec F, Hoeppner J. Perioperative platin-based chemotherapy for locally advanced esophagogastric adenocarcinoma: Postoperative chemotherapy has a substantial impact on outcome. Eur J Surg Oncol. 2015 Oct;41(10):1300-7.  
  17. Kulemann B, Pitman MB, Liss AS, Valsangkar N, Fernández-Del Castillo C, Lillemoe KD, Hoeppner J, Mino-Kenudson M, Warshaw AL, Thayer SP. Circulating tumor cells found in patients with localized and advanced pancreatic cancer. Pancreas. 2015 May;44(4):547-50.  
  18. Kulemann B, Hoeppner J, Wittel U, Glatz T, Keck T, Wellner UF, Bronsert P, Sick O, Hopt UT, Makowiec F, Riediger H. Perioperative and long-term outcome after standard pancreaticoduodenectomy, additional portal vein and multivisceral resection for pancreatic head cancer. J Gastrointest Surg. 2015 Mar;19(3):438-44.  
  19. Marjanovic G, Kuvendziska J, Holzner PA, Glatz T, Sick O, Seifert G, Kulemann B, Küsters S, Fink J, Timme S, Hopt UT, Wellner U, Keck T, Karcz WK. A prospective clinical study evaluating the development of bowel wall edema during laparoscopic and open visceral surgery. J Gastrointest Surg. 2014 Dec;18(12):2149-54.  
  20. Seifert GJ, Seifert M, Kulemann B, Holzner PA, Glatz T, Timme S, Sick O, Höppner J, Hopt UT, Marjanovic G. Searching for the molecular benchmark of physiological intestinal anastomotic healing in rats: an experimental study. Eur Surg Res. 2014;53(1-4):73-85.  
  21. Hoeppner J, Marjanovic G, Glatz T, Kulemann B, Hopt UT. [Hybrid laparoscopic thoracotomic esophagectomy with intrathoracic esophagogastric anastomosis]. Chirurg. 2014 Jul;85(7):628-35. doi: 10.1007/s00104-014-2783-1. German.  
  22. Bronsert P, Kohler I, Timme S, Kiefer S, Werner M, Schilling O, Vashist Y, Makowiec F, Brabletz T, Hopt UT, Bausch D, Kulemann B, Keck T, Wellner UF. Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer. Surgery. 2014 Jul;156(1):97-108.  
  23. Holzner P, Kulemann B, Seifert G, Glatz T, Chikhladze S, Höppner J, Hopt U, Timme S, Bronsert P, Sick O, Zhou C, Marjanovic G. Double 90 Degrees Counterrotated End-to-End-Anastomosis: An Experimental Study of an Intestinal Anastomosis Technique. Eur J Pediatr Surg. 2015 Jun;25(3):269-76.  
  24. Hoeppner J, Kulemann B, Hopt UT, Marjanovic G. [Laparoscopic total gastrectomy with extended lymphadenectomy and intracorporal circular stapled esophagojejunostomy]. Zentralbl Chir. 2014 Feb;139(1):17-9.  
  25. Glatz T, Boldt J, Timme S, Kulemann B, Seifert G, Holzner PA, Chikhladze S, Grüneberger JM, Küsters S, Sick O, Höppner J, Hopt UT, Marjanovic G. Impact of intraoperative temperature and humidity on healing of intestinal anastomoses. Int J Colorectal Dis. 2014 Apr;29(4):469-75.  
  26. Kulemann B, Fischer A, Hoeppner J. Esophageal stenosis caused by a rare entity. Gastroenterology. 2014 Mar;146(3):618-871.  
  27. Wellner UF*, Kulemann B, Lapshyn H, Hoeppner J, Sick O, Makowiec F, Bausch D,  Hopt UT, Keck T. Postpancreatectomy hemorrhage--incidence, treatment, and risk factors in over 1,000 pancreatic resections. J Gastrointest Surg. 2014 Mar;18(3):464-75.  
  28. Hoeppner J, Kulemann B, Seifert G, Marjanovic G, Fischer A, Hopt UT, Richter-Schrag HJ. Covered self-expanding stent treatment for anastomotic leakage: outcomes in esophagogastric and esophagojejunal anastomoses. Surg Endosc. 2014 May;28(5):1703-11.  
  29. Hoeppner J, Zirlik K, Brunner T, Bronsert P, Kulemann B, Sick O, Marjanovic G, Hopt UT, Makowiec F. Multimodal treatment of locally advanced esophageal adenocarcinoma: which regimen should we choose? Outcome analysis of perioperative chemotherapy versus neoadjuvant chemoradiation in 105 patients. J Surg Oncol. 2014 Mar;109(3):287-93.  
  30. Kulemann B*, Timme S, Seifert G, Holzner PA, Glatz T, Sick O, Chikhladze S, Bronsert P, Hoeppner J, Werner M, Hopt UT, Marjanovic G. Intraoperative crystalloid overload leads to substantial inflammatory infiltration of intestinal anastomoses-a histomorphological analysis. Surgery. 2013 Sep;154(3):596-603.  
  31. Makowiec F, Baier P, Kulemann B, Marjanovic G, Bronsert P, Zirlik K, Henke M, Hopt UT, Hoeppner J. Improved long-term survival after esophagectomy for esophageal cancer: influence of epidemiologic shift and neoadjuvant therapy. J Gastrointest Surg. 2013 Jul;17(7):1193-201.  
  32. Hoeppner J, Kulemann B, Marjanovic G, Bronsert P, Hopt UT. Limited resection for duodenal gastrointestinal stromal tumors: Surgical management and clinical outcome. World J Gastrointest Surg. 2013 Feb 27;5(2):16-21.  
  33. Rosow DE, Liss AS, Strobel O, Fritz S, Bausch D, Valsangkar NP, Alsina J, Kulemann B, Park JK, Yamaguchi J, LaFemina J, Thayer SP. Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench. Surgery. 2012 Sep;152(3 Suppl 1):S19-32.  
  34. Scherber C, Aranyosi AJ, Kulemann B, Thayer SP, Toner M, Iliopoulos O, Irimia D. Epithelial cell guidance by self-generated EGF gradients. Integr Biol (Camb). 2012 Mar;4(3):259-69.  
  35. Holzner PA, Kulemann B, Kuesters S, Timme S, Hoeppner J, Hopt UT, Marjanovic G. Impact of remote ischemic preconditioning on wound healing in small bowel anastomoses. World J Gastroenterol. 2011 Mar 14;17(10):1308-16.  
  36. Karcz WK, Kulemann B, Seifert GJ, Schrag HJ, Küsters S, Marjanovic G, Grüneberger JM, Braun A. Video. Laparoscopic extirpation of a fork from the duodenum. Surg Endosc. 2011 Jul;25(7):2363.
  37. Baumann T, Grueneberger J, Pache G, Kuesters S, Marjanovic G, Kulemann B, Holzner P, Karcz-Socha I, Suesslin D, Hopt UT, Langer M, Karcz WK. Three-dimensional stomach analysis with computed tomography after laparoscopic sleeve gastrectomy: sleeve dilation and thoracic migration. Surg Endosc. 2011 Jul;25(7):2323-9.  
  38. Karcz WK, Krawczykowski D, Kuesters S, Marjanovic G, Kulemann B, Grobe H, Karcz-Socha I, Hopt UT, Bukhari W, Grueneberger JM. Influence of Sleeve Gastrectomy on NASH and Type 2 Diabetes Mellitus. J Obes. 2011;2011:765473.  
  39. Marjanovic G, Holzner P, Kulemann B, Kuesters S, Karcz WK, Timme S, Zur Hausen A, Baumann T, Hopt UT, Obermaier R, Hoeppner J. Pitfalls and technical aspects during the research of intestinal anastomotic healing in rats. Eur Surg Res. 2010;45(3-4):314-20.  
  40. Marjanovic G, Winkler K, Schewe T, Küsters S, Hopt UT, Kulemann B, Karcz WK. [Metabolic surgery and remission of type 2 diabetes]. Dtsch Med Wochenschr. 2010 May;135(20):1020-4.  

    *Geteilte Erstautorschaft

Kontakt

Telefon: 0761 270-24010
Fax: 0761 270-27820
birte.kulemann@
uniklinik-freiburg.de

Klinik für Allgemein- und Viszeralchirurgie
Department Chirurgie
Universitätsklinikum Freiburg
Hugstetter Str. 55
79106 Freiburg