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Klinik für Allgemein- und Viszeralchirurgie

PD Dr. Birte Kulemann

Funktionsoberärztin

Ausbildung:

  • 2001 Abitur am Gymnasium Oberalster, Hamburg
  • 2001-2008 Medzinstudium in Kiel, Freiburg, Los Angeles and Buenos Aires
  • 2/2009 – 12/2010 Assistenzärztin in der Abteilung Allgemein- und Viszeralchirirugie der Chirurgischen Universitätsklinik Freiburg
  • 1/2011-12/2011 Surgical Research Fellowship an der MGH, Harvard Medical School, Boston (Pancreatic Biology Research Laboratory, Sarah P Thayer M.D. , PhD. and Andrew L Warsahw M.D.)
  • 1/2012-5/2015 Wissenschaftliche Mitarbeiterin in der Abteilung Allgemein- und Viszeralchirurgie der Chirurgischen Universitätsklinik Freiburg
  • 5/2015-3/2016 Mutterschutz und Elternzeit
  • Seit 4/2016 Wissenschaftliche Mitarbeiterin in der Klinik für Allgemein- und Viszeralchirurgie der Chirurgischen Universitätsklinik Freiburg
  • 6/2017 Fachärztin für Viszeralchirurgie und Beantragung der venia legendi
  • 10/2017 Stellvertredende Verantwortliche für den Bereich endokrine Chirurgie (Leitung Prof. Dr. med. O. Thomusch)
  • 04/2018 Ernennung zur Funktionsoberärztin
  • 05/2018-04/2019 Mutterschutz und Elternzeit, Geburt der Tochter 06/2018
  • 12/2018 Habilitation und Erlangung der Venia legendi für Viszeralchirurgie, Titel der Arbeit: "Zirkulierende Tumorzellen bei Patienten mit Pankreaskarzinom"
  • seit 4/2019 Fellow des Berta-Ottenstein Advanced Clinician Scientist Programms der Med. Fakultät der Universitätsklinik Freiburg (20% Forschung, 80 % klnisch-chirurgische Tätigkeit)
  • seit 1/2020 Leitung des Bereichs Bauchwandchirurgie der Klinik für Allgemein- und Viszeralchirurgie

Promotion:

  • 2009 bei PD Dr. A. Clad, Universitätsfrauenklinik Freiburg: "Chlamydia trachomatis - a prevalence study in 2794 women in childbed" (magna cum laude

Habilitation

  • 2018 Titel: „Zirkulierende Tumorzellen bei Patienten mit Pankreaskarzinom“

Preise:

  • 2017 Ludwig-Rehn-Preis der Mittelrheinischen Chirurgenvereinigung
  • 2017 FamSurg Preis der Firma Storz

Eingeworbene Drittmittel:

Else Kröner-Fresenius-Stiftung    181.331 €

Fördergesellschaft Forschung Tumorbiologie „Liquid Biopsy Initiative“      182.402 €

Berta-Ottenstein Advanced Clinician Scientist Programm    38.460 €

DKH, Comprehensive Cancer Center Freiburg (CCCF)

Förderprogramm: „Frühe Klinische Studien in onkologischen Spitzenzentren“ (DKH 110536)   45.500 €

Gesamt 447.693€

 

Interessensschwerpunkte:

  • Pankreaskarzinom
  • Zirkulierende Tumorzellen
  • Intestinale Anastomoseneheilung

 

Publikationen (Stand 05/2020)

  1. Glatz T, Kulemann B, Kuvendjiska J, Fichtner-Feigl S, Hoeppner J. Short-term and long-term outcomes of oesophagogastric surgery for cancer in obese and normal weight patients. ANZ J Surg. 2020 Mar;90(3):277-282. IF: 1,158
  2. Kuvendjiska J, Marjanovic G, Glatz T, Kulemann B, Hoeppner J. Hybrid Minimally Invasive Esophagectomy-Surgical Technique and Results. J Clin Med. 2019 Jul 5;8(7). IF: 5,688
  3. Kuvendjiska J, Bronsert P, Martini V, Lang S, Pitman MB, Hoeppner J, Kulemann B.  Non-Metastatic Esophageal Adenocarcinoma: Circulating Tumor Cells in the Course of Multimodal Tumor Treatment.  Cancers (Basel). 2019 Mar 21;11(3). IF: 6,072
  4. Oria VO, Lopatta P, Schmitz T, Preca BT, Nyström A, Conrad C, Bartsch JW, Kulemann B, Hoeppner J, Maurer J, Bronsert P, Schilling O. ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma. Mol Oncol. 2019 Feb;13(2):456-479. IF: 5,264
  5. Seifert GJ, Leithold G, Kulemann B, Holzner PA, Glatz T, Hoeppner J, Kirste S, Marjanovic G, Laessle C. The effect of pasireotide on intestinal anastomotic healing with and without whole-body irradiation in a rat model. Int J Colorectal Dis. 2019 Feb;34(2):337-345. IF: 2,533
  6. [Circulating tumor cells in pancreatic cancer : Results of morphological and molecular analyses and comparisons with the primary tumor]. Timme-Bronsert S, Bronsert P, Werner M, Kulemann B, Höppner J. Pathologe. 2018 Dec;39(Suppl 2):311-314. IF: 0,555
  7. Kulemann B, Rösch S, Seifert S, Timme S, Bronsert P, Seifert G, Martini V, Kuvendjiska J, Glatz T, Hussung S, Fritsch R, Becker H, Pitman MB, Hoeppner J. Pancreatic cancer: Circulating Tumor Cells and Primary Tumors show Heterogeneous KRAS Mutations. Sci Rep 2017 Oct 27;7(1):14631. IF: 5,228
  8. Enderle-Ammour K, Bader M, Ahrens TD, Franke K, Timme S, Csanadi A, Hoeppner J, Kulemann B, Maurer J, Reiss P, Schilling O, Keck T, Brabletz T, Stickeler E, Werner M, Wellner UF, Bronsert P. Form follows function: Morphological and immunohistological insights into epithelial-mesenchymal transition characteristics of tumor buds. Tumour Biol. 2017 May;39(5):1010428317705501. IF: 2.926
  9. Fuellgraf H, Schilling O, Lai ZW, Kulemann B, Timme S, Makowiec F, F. Shahinian JH, Hoeppner J, Werner M, Hopt UT, Wellner UF, Bronsert P. The Prognostic Impact of the Carcinoembryonic Antigen in Ampullary Cancer - A Retrospective Single Center Study. J Cancer. 2017 Feb 25;8(4):657-664.IF: 3,609
  10. Rosenbaum MW, Cauley CE, Kulemann B, Liss AS, Castillo CF, Warshaw AL, Lillemoe KD, Thayer SP, Pitman MB. Cytologic characteristics of circulating epithelioid cells in pancreatic disease. Cancer Cytopathol. 2017 May;125(5):332-340. IF: 5,649
  11. Glatz T, Kulemann B, Marjanovic G, Bregenzer S, Makowiec F, Hoeppner J. Postoperative fluid overload is a risk factor for adverse surgical outcome in patients undergoing esophagectomy for esophageal cancer: a retrospective study in 335 patients.BMC Surg. 2017 Jan 13;17(1):6. doi: 10.1186/s12893-016-0203-9. IF: 1,469
  12. Glatz T, Marjanovic G, Kulemann B, Sick O, Hopt UT, Hoeppner J. Hybrid minimally invasive esophagectomy vs. open esophagectomy: a matched case analysis in 120 patients. Langenbecks Arch Surg. 2017 Mar;402(2):323-331. IF:  2,149
  13. Glatz T, Marjanovic G, Kulemann B, Hipp J, Theodor Hopt U, Fischer A, Richter-Schrag HJ, Hoeppner J. Management and outcome of esophageal stenting for spontaneous esophageal perforations. Dis Esophagus. 2017 Feb 1;30(3):1-6.IF: 2,146
  14. Kulemann B, Fritz M, Glatz T, Marjanovic G, Sick O, Hopt UT, Hoeppner J, Makowiec F. Complications after Pancreaticoduodenectomy are Associated with higher Amounts of Intra- and Postoperative Fluid Therapy: A single Centre Retrospective Cohort Study. Ann Med Surg (Lond). 2017 Feb 27;16:23-29. IF: 0
  15. Kulemann B, Liss AS, Warshaw AL, Seifert S, Bronsert P, Glatz T, Pitman MB, Hoeppner J. KRAS mutations in pancreatic circulating tumor cells: a pilot study. Tumour Biol. 2016 Jun;37(6):7547-54. IF: 2,926
  16. Shahinian JH, Fuellgraf H, Tholen S, Mastroianni J, Knopf JD, Kuehs M, Mayer B, Schlimpert M, Kulemann B, Kuesters S, Hoeppner J, Wellner UF, Werner M, Hopt UT, Zeiser R, Bronsert P, Schilling O. Pregnancy Specific β-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival.  J Cancer. 2016 Oct 17;7(14):2018-2027. IF: 3,609
  17. Riediger H, Kulemann B, Wittel U, Adam U, Sick O, Neeff H, Höppner J, Hopt UT, Makowiec F.  Prognostic Role of Log Odds of Lymph Nodes After Resection of Pancreatic Head Cancer.  J Gastrointest Surg. 2016 Oct;20(10):1707-15. IF: 2,807
  18. Kulemann B, Liss AS, Warshaw AL, Seifert S, Bronsert P, Glatz T, Pitman MB, Hoeppner J. KRAS mutations in pancreatic circulating tumor cells: a pilot study. Tumour Biol. 2016 Jun;37(6):7547-54. IF: 2,926
  19. Wellner UF, Krauss T, Csanadi A, Lapshyn H, Bolm L, Timme S, Kulemann B, Hoeppner J, Kuesters S, Seifert G, Bausch D, Schilling O, Vashist YK, Bruckner T, Langer M, Makowiec F, Hopt UT, Werner M, Keck T, Bronsert P. Mesopancreatic Stromal Clearance Defines Curative Resection of Pancreatic Head Cancer and Can Be Predicted Preoperatively by Radiologic Parameters: A Retrospective Study. Medicine (Baltimore). 2016 Jan;95(3):e2529. IF: 1,206
  20. Glatz T, Lederer AK, Kulemann B, Seifert G, Holzner PA, Hopt UT, Hoeppner J, Marjanovic G. The degree of local inflammatory response after colonic resection depends on the surgical approach: an observational study in 61 patients. BMC Surg. 2015 Oct 6;15:108. IF: 1,469
  21. Glatz T, Bronsert P, Schäfer M, Kulemann B, Marjanovic G, Sick O, Hopt UT, Zirlik K, Makowiec F, Hoeppner J. Perioperative platin-based chemotherapy for locally advanced esophagogastric adenocarcinoma: Postoperative chemotherapy has a substantial impact on outcome.    Eur J Surg Oncol. 2015 Oct;41(10):1300-7. IF3,009
  22. Cauley CE, Pitman MB, Zhou J, Perkins J, Kulemann B, Liss AS, Fernandez-Del Castillo C, Warshaw AL, Lillemoe KD, Thayer SP. Circulating Epithelial Cells in Patients with Pancreatic Lesions: Clinical and Pathologic Findings. J Am Coll Surg. 2015 Sep;221(3):699-707. IF: 5,122
  23. Kulemann B, Pitman MB, Liss AS, Valsangkar N, Fernández-del Castillo C,  Lillemoe KD, Hoeppner J, Mino-Kenudson M, Warshaw AL, Thayer SP. Circulating tumor cells found in patients with localized and advanced pancreatic cancer. Pancreas 2015 May;44(4):547-50. IF: 2,738
  24. Kulemann B, Hoeppner J, Wittel U, Glatz T, Keck T, Wellner UF, Bronsert P. Sick O, Hopt UT, Makowiec F, Riediger H. Perioperative and Long-Term Outcome after Standard Pancreaticoduodenectomy, additional Portal Vein- and Multivisceral- Resection for Pancreatic Head Cancer. J Gastrointest Surg. 2015 Mar;19(3):438-44. IF: 2,807
  25. Marjanovic G, Kuvendziska J, Holzner PA, Glatz T, Sick O, Seifert G, Kulemann B, Küsters S, Fink J, Timme S, Hopt UT, Wellner U, Keck T, Karcz WK. A prospective clinical study evaluating the development of bowel wall edema during laparoscopic and open visceral surgery. J Gastrointest Surg. 2014 Dec;18(12):2149-54. IF:  2,798
  26. Seifert GJ, Seifert M, Kulemann B, Holzner PA, Glatz T, Timme S, Sick O, Höppner J, Hopt UT, Marjanovic G. Searching for the molecular benchmark of physiological intestinal anastomotic healing in rats: an experimental study. Eur Surg Res. 2014;53(1-4):73-85. IF : 1,431
  27. Hoeppner J, Marjanovic G, Glatz T, Kulemann B, Hopt UT. [Hybrid laparoscopic thoracotomic esophagectomy with intrathoracic esophagogastric anastomosis]. Chirurg. 2014 Jul;85(7):628-35. IF: 0,516
  28. Bronsert P, Kohler I, Timme S, Kiefer S, Werner M, Schilling O, Vashist Y, Makowiec F, Brabletz T, Hopt UT, Bausch D, Kulemann B, Keck T, Wellner UF. Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer.  Surgery. 2014 Jul;156(1):97-108. IF: 3,380
  29. Holzner P, Kulemann B, Seifert G, Glatz T, Chikhladze S, Höppner J, Hopt U, Timme S, Bronsert P, Sick O, Zhou C, Marjanovic G. Double 90 Degrees Counterrotated End-to-End-Anastomosis: An Experimental Study of an Intestinal Anastomosis Technique. Eur J Pediatr Surg. 2014 May 12. IF: 1,269
  30. Wellner UF, Kulemann B, Lapshyn H, Hoeppner J, Sick O, Makowiec F, Bausch D, Hopt UT, Keck T. Postpancreatectomy hemorrhage--incidence, treatment, and risk factors in over 1,000 pancreatic resections. J Gastrointest Surg. 2014 Mar;18(3):464-75. *Geteilte Erstautorenschaft. IF:  2,798
  31. Hoeppner J, Kulemann B, Hopt UT, Marjanovic G. [Laparoscopic total gastrectomy with extended lymphadenectomy and intracorporal circular stapled esophagojejunostomy]. Zentralbl Chir. 2014 Feb;139(1):17-9. IF:  1,188
  32. Glatz T, Boldt J, Timme S, Kulemann B, Seifert G, Holzner PA, Chikhladze S, Grüneberger JM, Küsters S, Sick O, Höppner J, Hopt UT, Marjanovic G. Impact of intraoperative temperature and humidity on healing of intestinal anastomoses. Int J Colorectal Dis. 2014 Apr;29(4):469-75. IF: 2,449
  33. Hoeppner J, Kulemann B, Seifert G, Marjanovic G, Fischer A, Hopt UT, Richter-Schrag HJ. Covered self-expanding stent treatment for anastomotic leakage: outcomes in esophagogastric and esophagojejunal anastomoses.  Surg Endosc. 2014 May;28(5):1703-11. IF: 3,540
  34. Hoeppner J, Zirlik K, Brunner T, Bronsert P, Kulemann B, Sick O, Marjanovic G, Hopt UT, Makowiec F. Multimodal treatment of locally advanced esophageal adenocarcinoma: which regimen should we choose? Outcome analysis of perioperative chemotherapy versus neoadjuvant chemoradiation in 105 patients. J Surg Oncol. 2014 Mar;109(3):287-93. IF:  3,151
  35. Kulemann B, Timme S, Seifert G, Holzner PA, Glatz T, Sick O, Chikhladze S, Bronsert P, Hoeppner J, Werner M, Hopt UT, Marjanovic G. Intraoperative crystalloid overload leads to substantial inflammatory infiltration of intestinal anastomoses-a histomorphological analysis. Surgery. 2013 Sep;154(3):596-603 .  *Geteilte Erstautorenschaft, IF:  3,105
  36. Makowiec F, Baier P, Kulemann B, Marjanovic G, Bronsert P, Zirlik K, Henke M, Hopt UT, Hoeppner J. Improved long-term survival after esophagectomy for esophageal cancer: influence of epidemiologic shift and neoadjuvant therapy. J Gastrointest Surg. 2013 Jul;17(7):1193-201. IF: 2,807
  37. Hoeppner J, Kulemann B, Marjanovic G, Bronsert P, Hopt UT. Limited resection for duodenal gastrointestinal stromal tumors: Surgical management and clinical outcome. World J Gastrointest Surg. 2013 Feb 27;5(2):16-21. IF: 0
  38. Rosow DE, Liss AS, Strobel O, Fritz S, Bausch D, Valsangkar NP, Alsina J, Kulemann B, Park JK, Yamaguchi J, LaFemina J, Thayer SP. Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench. Surgery. 2012 Sep;152(3 Suppl 1):S19-32. IF: 3,265
  39. Scherber C, Aranyosi AJ, Kulemann B, Thayer SP, Toner M, Iliopoulos O, Irimia D. Epithelial cell guidance by self-generated EGF gradients. Integr Biol (Camb). 2012 Mar;4(3):259-69. IF: 4,321

Kontakt

Telefon: 0761 270-24010
Fax: 0761 270-27820
birte.kulemann@
uniklinik-freiburg.de

Klinik für Allgemein- und Viszeralchirurgie
Department Chirurgie
Universitätsklinikum Freiburg
Hugstetter Str. 55
79106 Freiburg