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Klinik für Allgemein- und Viszeralchirurgie

Prof. Dr. Uwe Wittel

Geschäftsführender Oberarzt
Leiter Internationales Pankreaskarzinomzentrum

Beruflicher Werdegang, Ausbildung und Berufserfahrung

1991-1997 Studium der Humanmedizin an der Albert Einstein Universität Ulm und Eberhard Karls Universität Tübingen
1998-2000 Arzt im Praktikum und wissenschaftlicher Assistent an der Chirurgischen Universitätsklinik Ulm, Abteilung für Allgemein-, und Visceralchirurgie (Direktor: Prof. Dr. H.G. Beger
2000-2002 Postdoctoral Fellow an der University of Nebraska, Medical Center, Abteilung für Biochemie und Molekularbiologie und Eppley Institute in den Arbeitsgruppen von S.K Batra, B. Gold und P.M. Pour
seit 2002 Wissenschaftlicher Assistent an der Chirurgischen Universitätsklinik Freiburg, Abteilung für Allgemein- und Viszeralchirurgie (Direktor: Prof. Dr. Dr. h. c. U. T. Hopt)
2007 Facharzt für Chirurgie (Landesärztekammer Südbaden)
2009Ernennung zum Oberarzt

Akademischer Werdegang

2000Promotion an der Albert Einstein Universität Ulm, Klinik für Chirurgie. Titel: „Die Beteiligung von Sauerstoffradikalen an der Entstehung der akuten alkoholinduzierten Pankreatitis.“
2009Habilitation für das Fach Chirurgie an der Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg. Titel: „Pathogenetische Faktoren der akuten Pankreatitis“
2016Ernennung zum Außerplanmäßigen Professor der Albert-Ludwigs-Universität Freiburg

Forschungsschwerpunkte

Experimentelle Forschungsgruppe Pankreatits

  • Identifikation von differentiell regulierten Genen in der schweren akuten Pankreatitis.
  • Untersuchung diagnostischer Parameter zur frühzeitigen Identifikation einer infizierten Pankreasnekrose im Rahmen der akuten nekrotisierenden Pankreatitis.
  • Einfluss einzelner Gene auf die Entwicklung eines systemischen inflammatorischen Response Syndroms im Rahmen der akuten Pankreatitis.

Klinisch-Experimentelle Forschungsgruppe Pankreaskarzinom

  • Studienleiter prospektiver Studie zur Untersuchung der humoralen anti-Tumor Immunantwort von Patienten mit Adenokarzinomen des Pankreas.
  • Identifikation, Herstellung und Modifikation humaner anti-Tumor Antikörper aus Patientenproben in Kooperation mit Prof. Batra, Departement of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, US

Publikationen

Mintziras I, Keck T, Werner J, Fichtner-Feigl S, Wittel U, Senninger N, Vowinkel T, Köninger J, Anthuber M, Geißler B, Bartsch DK; StuDoQ|Pancreas Study Group of the German Society for General, Visceral Surgery (DGAV). Indications for resection and perioperative outcomes of surgery for pancreatic neuroendocrine neoplasms in Germany: an analysis of the prospective DGAV StuDoQ|Pancreas registry. Surg Today. 2019 Jun 25. doi: 10.1007/s00595-019-01838-1. [Epub ahead of print] PubMed PMID: 31240463.

 Wicha SG, Mundkowski RG, Klock A, Hopt UT, Drewelow B, Kloft C, Wellner UF, Keck T, Wittel UA. Is Moxifloxacin a Treatment Option for Pancreatic Infections? A Pharmacometric Analysis of Serum and Pancreatic Juice. J Clin Pharmacol. 2019 May 20. doi: 10.1002/jcph.1445. [Epub ahead of print] PubMed PMID: 31111505.

Lagies S, Schlimpert M, Braun LM, Kather M, Plagge J, Erbes T, Wittel UA, Kammerer B. Unraveling altered RNA metabolism in pancreatic cancer cells by liquid-chromatography coupling to ion mobility mass spectrometry. Anal Bioanal Chem. 2019 Apr 30. doi: 10.1007/s00216-019-01814-1. [Epub ahead of print] PubMed PMID: 31037374.

Kirste S, Landenberger N, Scholber J, Henne K, Wittel UA, Grosu AL. Retroperitoneal soft tissue sarcoma: low-dose neoadjuvant radiation therapy followed by surgery with or without intraoperative radiotherapy and adjuvant radiation therapy. Strahlenther Onkol. 2019 Jun;195(6):558-565. doi:10.1007/s00066-019-01464-3. Epub 2019 Apr 10. PubMed PMID: 30972454.

Bolm L, Petrova E, Weitz J, Rückert F, Wittel UA, Makowiec F, Lapshyn H, Bronsert P, Rau BM, Khatkov IE, Bausch D, Keck T, Wellner UF, Distler M. Prognostic relevance of preoperative bilirubin-adjusted serum carbohydrate antigen 19-9 in a multicenter subset analysis of 179 patients with distal cholangiocarcinoma. HPB (Oxford). 2019 Apr 5. pii: S1365-182X(19)30486-1. doi: 10.1016/j.hpb.2019.03.363. [Epub ahead of print] PubMed PMID: 30956162.

Mungroop TH, Klompmaker S, Wellner UF, Steyerberg EW, Coratti A, D'Hondt M, de Pastena M, Dokmak S, Khatov I, Saint-Marc O, Wittel U, Abu Hilal M, Fuks D, Poves I, Keck T, Boggi U, Besselink MG; European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS). Updated Alternative Fistula Risk Score (ua-FRS) to Include Minimally Invasive Pancreatoduodenectomy: Pan-European Validation. Ann Surg. 2019 Feb 13. doi: 10.1097/SLA.0000000000003234. [Epub ahead of print] PubMed PMID: 30829699.

Ettrich TJ, Berger AW, Perkhofer L, Daum S, König A, Dickhut A, Wittel U, Wille K, Geissler M, Algül H, Gallmeier E, Atzpodien J, Kornmann M, Muche R, Prasnikar N, Tannapfel A, Reinacher-Schick A, Uhl W, Seufferlein T. Neoadjuvant plus adjuvant or only adjuvant nab-paclitaxel plus gemcitabine for resectable pancreatic cancer - the NEONAX trial (AIO-PAK-0313), a prospective, randomized, controlled, phase II study of the AIO pancreatic cancer group. BMC Cancer. 2018 Dec 29;18(1):1298. doi: 10.1186/s12885-018-5183-y. PubMed PMID: 30594153; PubMed Central PMCID: PMC6311014.

Kühlbrey CM, Kasper S, Chikhladze S, Seifert G, Hopt UT, Fichtner-Feigl S, Wittel UA. Bio-absorbable sealants for reinforcing the pancreatic stump after distal pancreatectomy are critical. J Hepatobiliary Pancreat Sci. 2019 Mar;26(3):96-103. doi: 10.1002/jhbp.604. Epub 2019 Feb 10. PubMed PMID: 30589508.

Mintziras I, Keck T, Werner J, Fichtner-Feigl S, Wittel U, Senninger N, Vowinkel T, Köninger J, Anthuber M, Geißler B, Bartsch DK; StuDoQ|Pancreas study group of the German Society for General and Visceral Surgery (DGAV). Implementation of Current ENETS Guidelines for Surgery of Small (≤2 cm) Pancreatic Neuroendocrine Neoplasms in the German Surgical Community: An Analysis of the Prospective DGAV StuDoQ|Pancreas Registry. World J Surg. 2019 Jan;43(1):175-182. doi: 10.1007/s00268-018-4751-2. PubMed PMID: 30097704.

Klompmaker S, van Hilst J, Wellner UF, Busch OR, Coratti A, D'Hondt M, Dokmak S, Festen S, Kerem M, Khatkov I, Lips DJ, Lombardo C, Luyer M, Manzoni A, Molenaar IQ, Rosso E, Saint-Marc O, Vansteenkiste F, Wittel UA, Bonsing B, Groot Koerkamp B, Abu Hilal M, Fuks D, Poves I, Keck T, Boggi U, Besselink MG; European consortium on Minimally Invasive Pancreatic Surgery (E-MIPS). Outcomes After Minimally-invasive Versus Open Pancreatoduodenectomy: A Pan-European Propensity Score Matched Study. Ann Surg. 2018 Jun 1. doi: 10.1097/SLA.0000000000002850.[Epub ahead of print] PubMed PMID: 29864089.

Kousoulas L, Wittel U, Fichtner-Feigl S, Utzolino S. Hemoadsorption in a Case of Severe Septic Shock and Necrotizing Fasciitis Caused by Nontraumatic Renal Rupture due to Pyelonephritis with Obstructive Uropathy. Case Rep Crit Care. 2018 Apr 29;2018:5248901. doi: 10.1155/2018/5248901. eCollection 2018. PubMed PMID: 29854478; PubMed Central PMCID: PMC5949189.

Küsters S, Chikhladze S, Makowiec F, Sick O, Fichtner-Feigl S, Hopt UT, Wittel UA. Oncological outcome of laparoscopically assisted pancreatoduodenectomy for ductal adenocarcinoma in a retrospective cohort study. Int J Surg. 2018 Jul;55:162-166. doi: 10.1016/j.ijsu.2018.05.026. Epub 2018 May 25. PubMed PMID: 29807171.

Klett H, Fuellgraf H, Levit-Zerdoun E, Hussung S, Kowar S, Küsters S, Bronsert P, Werner M, Wittel U, Fritsch R, Busch H, Boerries M. Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma. Front Genet. 2018 Apr 5;9:108. doi:10.3389/fgene.2018.00108. eCollection 2018. PubMed PMID: 29675033; PubMed Central PMCID: PMC5895731.

van Hilst J, de Rooij T, Klompmaker S, Rawashdeh M, Aleotti F, Al-Sarireh B, Alseidi A, Ateeb Z, Balzano G, Berrevoet F, Björnsson B, Boggi U, Busch OR, Butturini G, Casadei R, Del Chiaro M, Chikhladze S, Cipriani F, van Dam R, Damoli I, van Dieren S, Dokmak S, Edwin B, van Eijck C, Fabre JM, Falconi M, Farges O, Fernández-Cruz L, Forgione A, Frigerio I, Fuks D, Gavazzi F, Gayet B, Giardino A, Groot Koerkamp B, Hackert T, Hassenpflug M, Kabir I, Keck T, Khatkov I, Kusar M, Lombardo C, Marchegiani G, Marshall R, Menon KV, Montorsi M, Orville M, de Pastena M, Pietrabissa A, Poves I, Primrose J, Pugliese R, Ricci C, Roberts K, Røsok B, Sahakyan MA, Sánchez-Cabús S, Sandström P, Scovel L, Solaini L, Soonawalla Z, Souche FR, Sutcliffe RP, Tiberio GA, Tomazic A, Troisi R, Wellner U, White S, Wittel UA, Zerbi A, Bassi C, Besselink MG, Abu Hilal M; European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS). Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA): A Pan-European Propensity Score Matched Study. Ann Surg. 2019 Jan;269(1):10-17. doi: 10.1097/SLA.0000000000002561. PubMed PMID: 29099399.

Seifert GJ, Sander KC, Richter S, Wittel UA. Murine genotype impacts pancreatitis severity and systemic inflammation: An experimental study. Ann Med Surg (Lond). 2017 Sep 28;24:8-14. doi: 10.1016/j.amsu.2017.09.012. eCollection 2017 Dec. PubMed PMID: 29062479; PubMed Central PMCID: PMC5645008.

Ruess DA, Kayser C, Neubauer J, Fichtner-Feigl S, Hopt UT, Wittel UA. Carcinosarcoma of the Pancreas: Case Report With Comprehensive Literature Review. Pancreas. 2017 Oct;46(9):1225-1233. doi: 10.1097/MPA.0000000000000904. Review. PubMed PMID: 28902796.

Diener MK, Hüttner FJ, Kieser M, Knebel P, Dörr-Harim C, Distler M, Grützmann R, Wittel UA, Schirren R, Hau HM, Kleespies A, Heidecke CD, Tomazic A, Halloran CM, Wilhelm TJ, Bahra M, Beckurts T, Börner T, Glanemann M, Steger U, Treitschke F, Staib L, Thelen K, Bruckner T, Mihaljevic AL, Werner J, Ulrich A, Hackert T, Büchler MW; ChroPac Trial Group. Partial pancreatoduodenectomy versus duodenum-preserving pancreatic head resection in chronic pancreatitis: the multicentre, randomised, controlled, double-blind ChroPac trial. Lancet. 2017 Sep 9;390(10099):1027-1037. doi: 10.1016/S0140-6736(17)31960-8. PubMed PMID: 28901935.

Bolm L, Cigolla S, Wittel UA, Hopt UT, Keck T, Rades D, Bronsert P, Wellner UF. The Role of Fibroblasts in Pancreatic Cancer: Extracellular Matrix Versus Paracrine Factors. Transl Oncol. 2017 Aug;10(4):578-588. doi: 10.1016/j.tranon.2017.04.009. Epub 2017 Jun 26. PubMed PMID: 28658650; PubMed Central PMCID: PMC5487255.

Petrova E, Rückert F, Zach S, Shen Y, Weitz J, Grützmann R, Wittel UA, Makowiec F, Hopt UT, Bronsert P, Kühn F, Rau BM, Izrailov RE, Khatkov IE, Lapshyn H, Bolm L, Bausch D, Keck T, Wellner UF, Seifert G. Survival outcome and prognostic factors after pancreatoduodenectomy for distal bile duct carcinoma: a retrospective multicenter study. Langenbecks Arch Surg. 2017 Aug;402(5):831-840. doi: 10.1007/s00423-017-1590-9. Epub 2017 Jun 13. PubMed PMID: 28612115.

Siech M, Strauss P, Huschitt S, Bartsch DK, Wittel U, Keck T. The Indications for Laparoscopic Pancreatectomy. Dtsch Arztebl Int. 2017 Apr 14;114(15):263-268. doi: 10.3238/arztebl.2017.0263. PubMed PMID: 28468714; PubMed Central PMCID: PMC5424087.

Schmidt AI, Kühlbrey C, Lauch R, Wolff-Vorbeck G, Chikhladze S, Hopt UT, Wittel UA. The predominance of a naive T helper cell subset in the immune response of experimental acute pancreatitis. Pancreatology. 2017 Mar -Apr;17(2):209-218. doi: 10.1016/j.pan.2017.02.011. Epub 2017 Feb 22. PubMed PMID: 28258935.

Hager S, Makowiec F, Henne K, Hopt UT, Wittel UA. Significant benefits in survival by the use of surgery combined with radiotherapy for retroperitoneal soft tissue sarcoma. Radiat Oncol. 2017 Jan 26;12(1):29. doi:10.1186/s13014-017-0769-0. PubMed PMID: 28126006; PubMed Central PMCID:PMC5270353.

Lapshyn H, Bolm L, Kohler I, Werner M, Billmann FG, Bausch D, Hopt UT, Makowiec F, Wittel UA, Keck T, Bronsert P, Wellner UF. Histopathological tumor invasion of the mesenterico-portal vein is characterized by aggressive biology and stromal fibroblast activation. HPB (Oxford). 2017 Jan;19(1):67-74. doi: 10.1016/j.hpb.2016.10.002. Epub 2016 Nov 5. PubMed PMID: 27825542.

Wellner UF, Lapshyn H, Bartsch DK, Mintziras I, Hopt UT, Wittel U, Krämling HJ, Preissinger-Heinzel H, Anthuber M, Geissler B, Köninger J, Feilhauer K,Hommann M, Peter L, Nüssler NC, Klier T, Mansmann U, Keck T; StuDoQ Pancreasstudy group and members of StuDoQ|Pancreas registry of the German Society for General and Visceral Surgery (DGAV). Laparoscopic versus open distal pancreatectomy-a propensity score-matched analysis from the German StuDoQ|Pancreas registry. Int J Colorectal Dis. 2017 Feb;32(2):273-280. doi:10.1007/s00384-016-2693-4. Epub 2016 Nov 4. PubMed PMID: 27815701.

Seifert M, Seifert G, Wolff-Vorbeck G, Langenmair E, Hopt UT, Wittel UA. Inducing a humoral immune response to pancreatic cancer antigen. Cell Immunol.2016 Dec;310:150-155. doi: 10.1016/j.cellimm.2016.09.002. Epub 2016 Sep 6. PubMedPMID: 27663207.

Ruess DA, Probst M, Marjanovic G, Wittel UA, Hopt UT, Keck T, Bausch D. HDACi Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA) Delay but Fail toProtect against Warm Hepatic Ischemia-Reperfusion Injury. PLoS One. 2016 Aug 11;11(8):e0161233. doi: 10.1371/journal.pone.0161233. eCollection 2016. PubMed PMID: 27513861; PubMed Central PMCID: PMC4981462.

Riediger H, Kulemann B, Wittel U, Adam U, Sick O, Neeff H, Höppner J, Hopt UT, Makowiec F. Prognostic Role of Log Odds of Lymph Nodes After Resection of Pancreatic Head Cancer. J Gastrointest Surg. 2016 Oct;20(10):1707-15. doi: 10.1007/s11605-016-3200-5. Epub 2016 Jul 6. PubMed PMID: 27384432.

Honselmann KC, Krauss T, Geserick S, Wellner UF, Wittel U, Hopt UT, Keck T,Bausch D. Cystic lesions of the pancreas-is radical surgery really warranted?Langenbecks Arch Surg. 2016 Jun;401(4):449-56. doi: 10.1007/s00423-016-1416-1.Epub 2016 Apr 5. PubMed PMID: 27048403.

Lapshyn H, Bronsert P, Bolm L, Werner M, Hopt UT, Makowiec F, Wittel UA, Keck T, Wellner UF, Bausch D. Prognostic factors after pancreatoduodenectomy with en bloc portal venous resection for pancreatic cancer. Langenbecks Arch Surg. 2016 Feb;401(1):63-9. doi: 10.1007/s00423-015-1363-2. Epub 2016 Jan 6. PubMed PMID: 26739620.

Ruess DA, Makowiec F, Chikhladze S, Sick O, Riediger H, Hopt UT, Wittel UA. The prognostic influence of intrapancreatic tumor location on survival after resection of pancreatic ductal adenocarcinoma. BMC Surg. 2015 Nov 28;15:123. doi: 10.1186/s12893-015-0110-5. PubMed PMID: 26615588; PubMed Central PMCID: PMC4663036.

Whetstone RD, Wittel UA, Michels NM, Gulizia JM, Gold B. Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate. Mol Carcinog. 2016 Jul;55(7):1187-95. doi: 10.1002/mc.22361. Epub 2015 Jul 8. PubMed PMID: 26153082; PubMed Central PMCID: PMC4706504.

Schmidt AI, Seifert GJ, Lauch R, Wolff-Vorbeck G, Chikhladze S, Hopt UT,Wittel UA. Organ-specific monocyte activation in necrotizing pancreatitis in mice. J Surg Res. 2015 Aug;197(2):374-81. doi: 10.1016/j.jss.2015.03.075. Epub 2015 Mar 31. PubMed PMID: 25982373.

Wittel UA, Makowiec F, Sick O, Seifert GJ, Keck T, Adam U, Hopt UT. Retrospective analyses of trends in pancreatic surgery: indications, operative techniques, and postoperative outcome of 1,120 pancreatic resections. World J Surg Oncol. 2015 Mar 12;13:102. doi: 10.1186/s12957-015-0525-6. PubMed PMID: 25880929; PubMed Central PMCID: PMC4364492.

Wittel UA, Schmidt AI, Poxleitner PJ, Seifert GJ, Chikhladze S, Puolakkainen P, Hopt UT, Kylänpää L. The chemokine ligand CXCL16 is an indicator of bacterialinfection in necrotizing pancreatitis. Pancreatology. 2015 Mar-Apr;15(2):124-30.doi: 10.1016/j.pan.2015.01.004. Epub 2015 Jan 23. PubMed PMID: 25661686.

Kulemann B, Hoeppner J, Wittel U, Glatz T, Keck T, Wellner UF, Bronsert P, Sick O, Hopt UT, Makowiec F, Riediger H. Perioperative and long-term outcome after standard pancreaticoduodenectomy, additional portal vein and multivisceralresection for pancreatic head cancer. J Gastrointest Surg. 2015 Mar;19(3):438-44. doi: 10.1007/s11605-014-2725-8. Epub 2015 Jan 8. PubMed PMID: 25567663.

Seifert GJ, Poxleitner PJ, Richter SC, Hopt UT, Wittel UA. Dissecting the effect of moxifloxacin in mice with infected necrosis in taurocholate induced necrotizing pancreatitis. Pancreatology. 2014 May-Jun;14(3):179-85. doi: 10.1016/j.pan.2014.02.003. Epub 2014 Feb 20. PubMed PMID: 24854613.

Kaur S, Chakraborty S, Baine MJ, Mallya K, Smith LM, Sasson A, Brand R, Guha S, Jain M, Wittel U, Singh SK, Batra SK: Potentials of plasma NGAL and MIC-1 as biomarker(s) in the diagnosis of lethal pancreatic cancer. Plos One, 2013; 8 (2) (online): e55171

Poxleitner PJ, Seifert G, Richter SC, Hopt UT, Wittel UA: Infected pancreatic necrosis increases the severity of experimental necrotizing pancreatitis in mice. Pancreas, 2013; 42 (7): 1150-1156

Seifert G, Kurzinger RP, Hopt UT, Wittel UA: Systemic differential gene regulation of the inter-alpha-trypsin inhibitor family in acute necrotizing pancreatitis in mice. J Surg Res, 2013; 180 (2): e83-e90

Seifert G, Seifert M, Wittel UA: Searching for the common denominator of systemic inflammation and tumor invasion in the cases of bikunin and the inter-alpha-trypsin inhibitor heavy chains. J Surg Res, 2013; 183 (2): 983-983

Seifert G, Kurzinger RP, Hopt UT, Wittel UA: Systemic differential gene regulation of the inter-alfa-trypsin inhibitor family in acute necrotizing pancreatitis in mice. J Surg Res, 2013 180(2):e83-90

Wittel UA, Momi N, Seifert G, Wiech T, Hopt UT, Batra SK: The pathobiological impact of cigarette smoke on pancreatic cancer development (review). Int J Oncol, 2012; 41 (1): 5-14

Haridas D, Chakraborty S, Ponnusamy MP, Lakshmanan I, Rachagani S, Cruz E, Kumar S, Das S, Lele SM, Anderson JM, Wittel UA, Hollingsworth MA, Batra SK: Pathobiological implications of MUC16 expression in pancreatic cancer. Plos One, 2011; 6 (10): e26839-e26839

Chakraborty S, Kaur S, Muddana V, Sharma N, Wittel UA, Papachristou GI, Whitcomb D, Brand RE, Batra SK: Elevated serum neutrophil gelatinase-associated lipocalin is an early predictor of severity and outcome in acute pancreatitis. Am J Gastroenterol, 2010; 105 (9): 2050-2059

Chipitsyna G, Gong Q, Anandanadesan R, Alnajar A, Batra SK, Wittel UA, Cullen DM, Akhter MP, Denhardt DT, Yeo CJ, Arafat HA. Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells. Int J Cancer. 2009; 125: 276-85.

Wittel UA, Wiech T, Chakraborty S, Boss B, Lauch R, Batra SK, Hopt UT. Taurocholate-induced pancreatitis: a model of severe necrotizing pancreatitis in mice. Pancreas. 2008; 36: e9-21.

Wittel UA, Singh AP, Henley BJ, Andrianifahanana M, Akhter MP, Cullen DM, Batra SK. Cigarette smoke-induced differential expression of the genes involved in exocrine function of the rat pancreas. Pancreas. 2006; 33: 364-70. Batra SK. Cigarette smoke-induced differential expression of the genes involved in exocrine function of the rat pancreas. Pancreas. 2006; 33: 364-70.

Wittel UA, Pandey KK, Andrianifahanana M, Johansson SL, Cullen DM, Akhter MP, Brand RE, Prokopczyk B, Batra SK. Chronic pancreatic inflammation induced by environmental tobacco smoke inhalation in rats. Am J Gastroenterol. 2006; 101: 148-59.

Chauhan SC, Jain M, Moore ED, Wittel UA, Li J, Gwilt PR, Colcher D, Batra SK. Pharmacokinetics and biodistribution of 177Lu-labeled multivalent single-chain Fv construct of the pancarcinoma monoclonal antibody CC49. Eur J Nucl Med Mol Imaging. 2005; 32: 264-73.

Wittel UA, Jain M, Goel A, Chauhan SC, Colcher D, Batra SK. The in vivo characteristics of genetically engineered divalent and tetravalent single-chain antibody constructs. Nucl Med Biol. 2005; 32: 157-64.

Wittel UA, Jain M, Goel A, Baranowska-Kortylewicz J, Kurizaki T, Chauhan SC, Agrawal DK, Colcher D, Batra SK. Engineering and characterization of a divalent single-chain Fv angiotensin II fusion construct of the monoclonal antibody CC49. Biochem Biophys Res Commun. 2005; 329: 168-76.

Wittel UA, Rau B, Gansauge F, Gansauge S, Nussler AK, Beger HG, Poch B. Influence of PMN leukocyte-mediated pancreatic damage on the systemic immune response in severe acute pancreatitis in rats. Dig Dis Sci. 2004; 49: 1348-57. Influence of PMN leukocyte-mediated pancreatic damage on the systemic immune response in severe acute pancreatitis in rats. Dig Dis Sci. 2004; 49: 1348-57.

Moniaux N, Varshney GC, Chauhan SC, Copin MC, Jain M, Wittel UA, Andrianifahanana M, Aubert JP, Batra SK. Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humans. J Histochem Cytochem. 2004; 52: 253-61.

Review Artikel

Wittel UA, Hopt UT, Batra SK. Cigarette smoke-induced pancreatic damage: experimental data. Langenbecks Arch Surg. 2008; 393: 581-8.

Kontakt

Telefon: 0761 270-26970
Fax: 0761 270-27820
uwe.wittel@uniklinik-freiburg.de

Klinik für Allgemein- und Viszeralchirurgie
Department Chirurgie
Universitätsklinikum Freiburg
Hugstetter Str. 55
79106 Freiburg