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Experimental Epilepsy ResearchDepartment of Neurosurgery

Dr. Ute Häussler

Postdoc

  • Research interests and techniques

Role of the hippocampal CA2 region in temporal lobe epilepsy (TLE)  

Structural plasticity of inhibitory interneurons in TLE 

Intrahippocampal kainate mouse model for TLE  

Human hippocampal tissue with Ammon’s horn sclerosis  

In vivo electrophysiology

Viral tracing of hippocampal projections

Microscopy

 

Heining K, Kilias A, Janz P, Häussler U, Kumar A, Haas CA, Egert U (2019) Bursts with high and low load of epileptiform spikes show context-dependent correlations in epileptic mice. eNeuro 6:0299-18. (access to article )

Tulke S, Haas CA, Häussler U (2019) Expression of brain-derived neurotrophic factor and structural plasticity in the dentate gyrus and CA2 region correlate with epileptiform activity. Epilepsia 60:1234-1247. (access to article)

Kilias A, Häussler U, Heining K, Froriep UP, Haas CA, Egert U (2018) Theta frequency decreases throughout the hippocampal formation in a focal epilepsy model. Hippocampus 28: 375-391. DOI: 10.1002/hipo.22838. (access to article)

Gremmelspacher T, Gerlach J, Hubbe A, Haas CA, Häussler U (2017) Neurogenic processes induced by very short periods of voluntary wheel-running in male mice. Front. Neurosci. 11:385. doi: 10.3389/fnins.2017.00385 (access to article)

Janz P*, Schwaderlapp N*, Heining K*, Häussler U, Korvink JG, von Elverfeldt D, Hennig J, Egert U, LeVan P*, Haas CA* (2017) Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy. *equal contribution. eLife 2017;6:e25742 doi: 10.7554/eLife.25742 (access to article)

Janz P, Savanthrapadian S, Häussler U, Kilias A, Nestel S, Kretz O, Kirsch M, Bartos M, Egert U, Haas CA (2017) Synaptic remodeling of entorhinal input contributes to an aberrant hippocampal network in temporal lobe epilepsy. Cerebral Cortex 27 (3): 2348-2364. (access to article)

Häussler U, Rinas K, Kilias A, Egert U, Haas CA (2016) Mossy fiber sprouting and pyramidal cell dispersion in the hippocampal CA2 region in a mouse model of temporal lobe epilepsy. Hippocampus 26: 577-88. doi:10.1002/hipo.22543. (access to article)

Winkelmann A, You X, Grünewald N, Haeussler U, Krestel H, Haas CA, Schwarz G, Chen W, Meier J (2015) Identification of a new genomic hot spot of evolutionary diversification of protein function. PLoS One 10:e0125413. (access to article)

Bedner P, Dupper A, Hüttmann K, Müller J, Herde MK, Dublin P, Deshpande T, Schramm J, Häussler U, Haas CA, Henneberger C, Theis M, Steinhäuser C (2015) Astrocyte uncoupling as a cause of human temporal lobe epilepsy. Brain 138; 1208-1222. (access to article)

Winkelmann A, Maggio N, Eller J, Caliskan G, Semtner M, Haussler U, Juttner R, Dugladze T, Smolinsky B, Kowalczyk S, Chronowska E, Schwarz G, Rathjen FG, Rechavi G, Haas CA, Kulik A, Gloveli T, Heinemann U, Meier JC (2014) Changes in neural network homeostasis trigger neuropsychiatric symptoms. The Journal of Clinical Investigation 124:696-711. (access to article)

Chai X, Münzner G, Zhao S, Tinnes S, Kowalski J, Haussler U, Young C, Haas CA, Frotscher M (2014) Epilepsy-Induced Motility of Differentiated Neurons. Cerebral Cortex 24:2130-2140. (access to article)

Marx M, Haas CA, Haussler U (2013) Differential vulnerability of interneurons in the epileptic hippocampus. Frontiers in Cellular Neuroscience 7:167. (access to article)

Fauser S, Haussler U, Donkels C, Huber S, Nakagawa J, Prinz M, Schulze-Bonhage A, Zentner J, Haas CA (2013) Disorganization of neocortical lamination in focal cortical dysplasia is brain-region dependent: evidence from layer-specific marker expression. Acta Neuropathologica Communications 1:47. (access to article)

Dugladze T, Maziashvili N, Borgers C, Gurgenidze S, Haussler U, Winkelmann A, Haas CA, Meier JC, Vida I, Kopell NJ, Gloveli T (2013) GABA(B) autoreceptor-mediated cell type-specific reduction of inhibition in epileptic mice. Proceedings of the National Academy of Sciences of the United States of America 110:15073-15078. (access to article)

Sibbe M, Haussler U, Dieni S, Althof D, Haas CA, Frotscher M (2012) Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus. The European Journal of Neuroscience 36:3643-3652. (access to article)

Haussler U, Bielefeld L, Froriep UP, Wolfart J, Haas CA (2012) Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy. Cerebral Cortex 22:26-36. (access to article)

Froriep UP, Kumar A, Cosandier-Rimele D, Haussler U, Kilias A, Haas CA, Egert U (2012) Altered theta coupling between medial entorhinal cortex and dentate gyrus in temporal lobe epilepsy. Epilepsia 53:1937-1947. (access to article)

Bechstein M, Haussler U, Neef M, Hofmann HD, Kirsch M, Haas CA (2012) CNTF-mediated preactivation of astrocytes attenuates neuronal damage and epileptiform activity in experimental epilepsy. Experimental Neurology 236:141-150. (access to article)

Heinrich C, Lahteinen S, Suzuki F, Anne-Marie L, Huber S, Haussler U, Haas C, Larmet Y, Castren E, Depaulis A (2011) Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy. Neurobiology of Disease 42:35-47. (access to article)

Lugert S, Basak O, Knuckles P, Haussler U, Fabel K, Gotz M, Haas CA, Kempermann G, Taylor V, Giachino C (2010) Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. Cell Stem Cell 6:445-456. (access to article)

Muller MC, Osswald M, Tinnes S, Haussler U, Jacobi A, Forster E, Frotscher M, Haas CA (2009) Exogenous reelin prevents granule cell dispersion in experimental epilepsy. Experimental Neurology 216:390-397. (access to article)

 

To reach earlier publications, please click on PubMed

  • Preprint

E Paschen, C Elgueta, K Heining, DM Vieira, C Orcinha, U Häussler, M Bartos, U Egert, P Janz, CA Haas (2020) Optogenetic low-frequency stimulation of dentate granule cells prevents seizure generation in experimental epilepsy. doi: https://doi.org/10.1101/2020.01.09.900084. (access to article)