Dr. Viviane Timmermann
Head of Computational Modelling
Contact
viviane.timmermann@uniklinik-freiburg.de
+49 (0)761 270 63955
Research Interests:
- Multiscale functional and structural modeling of mechanics-mediated effects on calcium homeostasis such as inter- and intracellular calcium wave propagation
- Mechano-electric coupling mechanisms
- Mathematical modeling of electro-mechano-energetics
Brief CV
Viviane Timmermann studied mathematics at the Technical University of Kaiserslautern (2008-2014) focusing on mathematical modelling of multi-body systems (algebraic differential equations). During her PhD in the Department of Computational Physiology at Simula Research Laboratory in Oslo, she worked on mathematical modelling and multiscale analysis of mechano-electric coupling mechanisms in cardiac myocytes with emphasis on how mechanical stimuli may contribute to generating myofilament-triggered calcium waves. Subsequently, she pursued a position as a postdoctoral fellow in the Cardiac Mechanics Research Group at UCSD. In the McCulloch Lab, she worked on understanding normal and pathological heart function in detailed subcellular electromechanical models of cardiac myocytes combining ‘dry’ computational and ‘wet’ experimental models. In 2021 Viviane joined the IEKM in Freiburg as head of the Computational Modelling group.
Selected Publications
- Timmermann V and McCulloch AD. Mechano-electric coupling and arrhythmogenic current generation in a computational model of coupled myocytes. Front Physiol 2020/1573
- Timmermann V. Mechano-electric coupling and arrhythmogenic current generation in a multi-scale computational model of coupled myocytes. The FASEB Journal 2020/34(S1)
- Timmermann V, Edwards AG, Sundnes J, Wall ST, and McCulloch AD. Arrhythmogenic current generation by myofilament- triggered Ca2+ release and sarcomere heterogeneity. Biophys J 2019/117:2471-2485
- Timmermann V, Vincent K, Sundnes J, and McCulloch AD. Mechano-electric feedback and arrhythmogenic current generation in a computational model of coupled myocytes. Molecular and Cellular Biomechanics 2019/16:139
- Timmermann V, Dejgaard LA, Haugaa KH, Edwards AG, Sundnes J, McCulloch AD, and Wall ST. An integrative appraisal of mechano-electric feedback mechanisms in the heart. Prog Biophys Mol Biol 2017/130:404-417