PD Dr. med. Ingo Hilgendorf
Coordinator of Translational Research
Contact
ingo.hilgendorf@uniklinik-freiburg.de
+49 (0)761 270 37844
Research Interests
- Retrieving research questions from clinical practice and putting novel insights on disease mechanisms into a clinical context
- Studying inflammation as a common denominator of conventional and novel cardiovascular risk factors
- Special focus on heterocellular interactions of innate immune cells from the single cell to the organism level
Brief CV
Ingo Hilgendorf studied Medicine at the University of Tuebingen and at Brown Medical School, Providence (2000-2007), receiving his medical doctoral (Dr. med.) degree in 2008. He then joined the Department of Cardiology at the University Hospital Freiburg (Chair: Prof. Christoph Bode) for his medical training. Receiving research scholarships from the German Research Foundation and the Society of Thrombosis and Haemostasis Research, he joined the group of Prof. Filip Swirski at the Center for Systems Biology at Harvard Medical School, Boston (2011-2013) for his postdoctoral training in immunology and cardiovascular research. Upon his return to Freiburg, he established the Research Group for Immunocardiology being awarded an Emmy Noether grant by the German Research Foundation, while also working as an attending physician, interventionalist and deputy of the head of the Department of Cardiology at the University Heart Center Freiburg-Bad Krozingen. Since 2021 Ingo coordinates the Translational Research at IEKM.
Selected Publications
- Härdtner C, Kornemann J […] Hilgendorf I. Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering. Basic Res Cardiol 2020/115:78
- Kessler T […] Hilgendorf I […] Sager HB. Hospital admissions with acute coronary syndromes during the COVID-10 pandemic in German cardiac care units. Cardiovasc Res 2020/116:1800-1901
- Wolf D […] Hilgendorf I […] Ley K. Pathogenic autoimmunity in atherosclerosis evolves from initially protective ApoB-reactive CD4+ T-regulatory cells. Circulation 2020/142:1279-1293
- Mauler M […] Hilgendorf I, Duerschmied D. Platelet serotonin aggravates myocardial ischemia/reperfusion injury via neutrophil degranulation. Circulation 2019/139:918-931
- Theurl I*, Hilgendorf I*, Nairz M* […] Swirski FK. On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nat Med 2016/22:945-951 (*joint auhorship)
- Lindau A […] Hilgendorf I. Atheroprotection through SYK Inhibition fails in established disease when local macrophage proliferation dominates lesion progression. Basic Res Cardiol 2016/111:20
- Ensan S […] Hilgendorf I […] Robbins CS. Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth. Nat Immunol 2016/17:159-168
- Hilgendorf I […] Swirski FK. Innate Response Activator B cells aggravate atherosclerosis by stimulating TH1 adaptive immunity. Circulation 2014/129:1677-1687
- Hilgendorf I […] Swirski FK. Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium. Circ Res 2014/14:1611–1622
- Robbins CS, Hilgendorf I […] Swirski FK. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med 2013/19:1166-117