Klinik für Frauenheilkunde

Gynäkologische Endokrinologie und Geburtshilfe

Im diesem Bereich werden unter der Leitung von PD Dr. Wolfgang Schäfer folgende Themen bearbeitet:

1. Optimierung der Diagnostik bei frühem vorzeitigem Blasensprun.
2. Wirkungsmechanismen therapeutischer Effekte von oralen Kontrazeptiva bei Dysmenorrhö.
3. Umweltchemikalien mit antagonistischer Wirkung am Progesteronrezeptor.

Veröffentlichungen

• Hanjalic-Beck, A., Schaefer, W.R., Deppert, W.R., Fischer, L., Stein, A., Seebacher, L., von Gradowski, A.S., Stuckenschneider, J., Zahradnik, H.P.: Chlormadinone acetate suppresses prostaglandin biosynthesis in human endometrial explants. Fertil Steril, im Druck
• Fischer, L., Deppert, W. R., Pfeifer, D., Stanzel, S., Weimer, M., Hanjalic-Beck, A., Stein, A., Straßer, M., Zahradnik, H.P., Schaefer, W.R.: Potential hazards to embryo implantation: A human endometrial in vitro model to identify antigestagenic chemicals. Toxicol Appl Pharmacol 260: 232-240, 2012
• Schäfer W.R., Fischer L., Roth K., Jüllig A.K., Stuckenschneider J.E., Schwartz P., Weimer M.,. Orlowska-Volk M, Hanjalic-Beck A., Kranz I., Deppert W.R., Zahradnik H.P.: Critical evaluation of human endometrial explants as an /ex vivo/ model system: a molecular approach. Mol Hum Reprod17:255-265, 2011
• Schaefer W.R., Fischer L., Deppert W.R., Hanjalic-Beck A., Seebacher L., Weimer M., Zahradnik H. P.: In vitro-Ishikawa cell test for assessing tissue-specific chemical effects on human endometrium. Reprod Toxicol 30: 89-93, 2010
• Schenk B., Weimer M., Bremer S., van der Burg B., Cortvrindt R., Freyberger A., Lazzari G., Pellizzer C., Piersma A., Schäfer W.R., Seiler A., Witters H., Schwarz M.: The ReProTect Feasibility Study, a novel comprehensive in vitro approach to detect reproductive toxicants, Reprod Toxicol 30: 210-218, 2010
• Hanjalic-Beck A., Gabriel B., Niemeyer C., Schaefer W., Schories M., Tempfer C., Keck C., Denschlag D.: Metformin versus acarbose therapy in patients with polycystic ovary syndrome (PCOS): a prospective randomized double-blind study. Gynecol Endocrinol 26: 690-697, 2010
• Schwendemann J., Sehringer B., Noethling C., Zahradnik H.P., Schäfer W.R.: Nitric oxide detection by DAF fluorescence in human myometrial tissue. Gyn Endocrinol 24: 306-311, 2008
• Hancke K., Strauch O., Kissel C., Gobel H., Schafer W., Denschlag D..: Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo. Fertil Steril 87:172-177, 2007
• Bremer, S., Brittebo, E., Dencker, L., Gustafson, A.L., Ehlert-Knudsen, L., Line, M., Olovsson, M., Pazos, P., Pellizzer, C., Ricci-Paulesu, L., Schaefer, W., Schwarz, M., Staud, F., Stavreus-Evers, A. Vähänkangas, K., In Vitro Tests for Detecting Chemicals Affecting the Implantation Process; Altern Lab Anim 35: 421-439, 2007
• Sehringer, B., Zahradnik, H.P., Deppert, W.R., Simon, M., Noethling, C., Schaefer, W.R.: Evaluation of different strategies for real-time RT-PCR expression analysis of corticotropin-releasing hormone and related proteins in human gestational tissues. Anal Bioanal Chem 383:768-775, 2005
• Schäfer W.R., Zahradnik H.P.: (Patho-)Physiologische Grundlagen des Geburtsbeginns. Neue Erkenntnisse als Ansatz für eine effiziente und sichere Einleitung der Geburt (Review). Gynäkologe 37: 305-313, 2004
• Sehringer, B., Zahradnik, H.P., Simon, M., Ziegler, R., Noethling,C., Schaefer, W.R.: mRNA expression profiles for corticotropin-releasing hormone (CRH), urocortin, CRH-binding protein (CRH-BP) and CRH-receptors in human term gestational tissues determined by real-time quantitative RT-PCR. J Mol Endocrinol 32: 339-348, 2004
• Wetzka, B., Sehringer, B., Schäfer, W.R., Biller, S., Hör, C., Benedek, E., Deppert, W.R., Zahradnik, H.P.: Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissues at term. Exp Clin Endocrinol Diab 111:1-8, 2003
• Werner, K., Schaefer, W.R., Schweer, H., Deppert, W.R., Karck, U., Zahradnik, H.P.: Characterization and identification of cytochrome P 450 metabolites of arachidonic acid released by human peritoneal macrophages obtained from the pouch of Douglas. Prostaglandins Leukot Essent Fatty Acids 67:397-404, 2002
• Schäfer W, Zahradnik HP: Programmierte Eskalation - Die Steuerung der Geburt. Geburtsh Frauenheilk 61:157-166, 2001
• Wetzka, B., Stehmans, A., Schäfer, W.R., Zahradnik, H.P.: Effects of nitric oxide donors on the contractility and the prostaglandin synthesis of myometrial strips from pregnant and non-pregnant women. Gynecol Endocrinol15: 34-42, 2001
• Sehringer, B., Schäfer, W.R., Wetzka, B., Deppert, W.R., Brunner-Spahr, R., Benedek, E., Zahradnik, H.P.: Formation of inflammatory cytokines in human term myometrium is stimulated by lipopolysaccharide but not by corticotropin releasing hormone. J Clin Endocrinol Metab 85, 4859-4865, 2000
• Wölfle, D., Marotzki, S., Dartsch, D., Schäfer, W., Marquardt, H.: Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Carcinogenesis 21, 15-21, 2000
• Schäfer, W.R., Herrmann, T., Meinhold-Heerlein, I., Deppert, W.R., Zahradnik, H.P.: Exposure of human endometrium to environmental estrogens, antiandrogens and organochlorine compounds. Fertil Steril 74, 558-563, 2000
• Schäfer, W.R., Zahradnik, H.P., Brückner, B., Herrmann, T.: Chlororganische Umweltchemikalien und Xenoöstrogene im menschlichen Endometrium. Umweltmed Forsch Prax 2, 281-288, 1997
• Schaefer, W.R., Werner, K., Schweer, H., Schneider, J., Arbogast, E., Zahradnik, H.P.: Cytochrome P450 metabolites of arachidonic acid in human placenta. Prostaglandins 54:677-687, 1997
• Wetzka, B., Nüsing, R., Charnock-Jones, D.S., Schäfer, W., Zahradnik, H.P., Smith, S.K.: Cyclooxygenase-1 and -2 in human placenta and placental bed after normal and pre-eclamptic pregnancies. Hum Reprod 12, 2313-2320, 1997
• Arbogast, E., Schäfer, W., Zahradnik, H.P.: Alterations of intrauterine eicosanoid production in pregnancy-induced hypertension: Decreased production of 12-hydroxyeicosatetraenoic acid in the placenta. Prostaglandins 51, 125-137, 1996
• Schäfer, W.R., Zahradnik, H.P., Frijus-Plessen, N., Schneider, K.: Anthropogene Substanzen mit unerwünschter Östrogenwirkung: Auswahl von expositionsrelevanten Stoffen. Umweltmed Forsch Prax 1, 35-42, 1996
• Schäfer, W.R., Zahradnik, H.P., Arbogast, E., Wetzka, B., Werner, K., Breckwoldt, M.: Arachidonate metabolism in human placenta, fetal membranes, decidua, and myometrium: Lipoxygenase and cytochrome P450 metabolites as main products in HPLC profiles. Placenta 17, 231-238, 1996
• Schäfer, W.R., Seufert, R.J., Casper, F.W., Zahradnik, H.P.: Urinary excretion of 2,3-dinor-6-keto-PGF_1α and 11-dehydro-TxB₂ by the gravid spontaneous hypertensive rat. Prostaglandins 52, 1-11, 1996
• Schäfer, W., Zahradnik, H.P., Breckwoldt, M.: Umweltschadstoffe in der Muttermilch. Dtsch Med Wschr 119, 560-565, 1994
• Zahradnik, H.P., Schäfer, W., Casper, F.W., Seufert, R.J., Gaillard, T., Bettendorf, H.: Urinary excretion of 6-keto-PGF1α, TxB2, and PGE2 in pregnancy-induced hypertension and preeclampsia. Hypertens Pregnancy 13, 201-209, 1994
• Wetzka, B., Schäfer, W., Zahradnik, H.P.: Eicosanoid production of frozen tissue in vitro is markedly changed. Prostaglandins Leukot Essent Fatty Acids 50, 303-304, 1994
• Wetzka, B., Bettendorf, H., Kommoss, F., Nüsing, R., Schäfer, W., Zahradnik, H.P.: Immunhistochemical localization of thromboxane synthase in human intrauterine tissues. Placenta 15, 389-398, 1994
• Kommoss, F., Pfisterer, J., Idris, T., Giese, E., Sauerbrei, E., Schäfer, W., Thome, M., Pfleiderer, A.: Steroid receptors in carcinoma of the breast. Analyt Quant Cytol Histol 16, 203-210, 1994
• Schäfer, W., Tielsch, J., Casper, F.W., Seufert, E.J., Zahradnik, H.P.: Urinary excretion of 6-keto-PGF_1α, TxB₂, and PGE₂ in a rat animal model for pre-eclampsia like syndrome. Prostaglandins 46, 167-175, 1993
• Wetzka, B., Schäfer, W., Scheibel, M., Nüsing, R., Zahradnik, H.P.: Eicosanoid production by intrauterine tissues before and after labor in short-term tissue culture. Prostaglandins 45, 571-581, 1993
• Schäfer, W., Sandermann, H.: Metabolism of pentachlorophenol in cell suspension cultures of wheat (Triticum aestivum L.). Tetrachlorocatechol as a primary metabolite. J Agric Food Chem 36, 370-377, 1988