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Institut für Medizinische Biometrie
und Statistik (IMBI)

Statistical aspects in clinical research

Reporting Guidelines as one instrument to improve quality and reproducibility

Dozent: Prof. Dr. Willi Sauerbrei
Beginn: Donnerstag, 21.01.2021
Ende: Donnerstag, 04.02.2021
insgesamt 3 Termine:

Teil 1: Donnerstag, 21.01.2021, 14.00 - 17.30 s.t.
Teil 2: Donnerstag, 28.01.2021, 14.00 - 17.30 s.t.
Teil 3: Donnerstag, 04.02.2021, 14.00 - 17.30 s.t.

Uhrzeit: 14.00 - 17.30 Uhr s.t.
Ort: Zoom
VLVZ: 04LE58S-IMBI-StatClinRes_FA
Language: English
Registration required:


Anmeldeschluss: 11.01.2021
Persönliche  Anmeldung per Email erforderlich bei Prof. Dr. Willi Sauerbrei


For several years the quality of research in the health sciences has been critiqued heavily. It is argued that serious improvement would be possible if biomedical research is better chosen, designed, done, analysed, regulated, managed, disseminated, and reported. Serious improvements are far from being simple for many of the issues mentioned, but suitable guidance documents have been developed to enhance on the reporting of research. Severe weaknesses in this area are unnecessary and can be avoided. Concerning issues in reporting of health science the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network acts as an umbrella (http://www.equator-network.org/).

Unfortunately, many reviews have clearly shown that the quality of reporting on observational studies is still bad. Many basic items of the study population are often not mentioned and relevant details of statistical analyses are not provided. To improve on the latter issue the REMARK profile was proposed (see item 12 in https://www.ncbi.nlm.nih.gov/pubmed/22675273).  An overview of the most relevant reporting guidelines will be provided. For several studies investigating a prognostic factor or deriving a prognostic index (https://www.tripod-statement.org/), we will illustrate that structured reporting is a key step in improving the transparency of analyses and understanding them better and assess the value of study reports. Participants are asked to assess the reporting quality of recent publications and to derive a REMARK profile for a prognostic factor study in cancer.  We will also discuss the value of recommendations for analyses given in boxes of several ‘Explanation and Elaboration’ papers of reporting guidelines. 

The seminar is aimed at students and researchers who are interested to learn more about good reporting of studies in the health sciences.