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Institute of Immunology

  • Mueller K, Schweier O, Pircher H,: Efficacy of IL-2-versus IL-15-stimulated CD8 T cells in adoptive immunotherapy.
    Eur J Immunol, 2008; 38: 2874-2885
  • Rosshart S, Hofmann M, Schweier O, Pfaff, AK, Yoshimoto T, Takeuchi T, Molnar E, Schamel WW, Pircher H,: Interaction of KLRG1 with E-cadherin: New functional and structural insights.
    Eur J Immunol, 2008; 38: 3354-3364
  • Simpson RJ, Cosgrove C, Ingram LA, Florida-James GD, Whyte GP, Pircher H, Guy K: Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise.
    Brain Behav Immun, 2008; 22 (4): 544-551
  • Keppler SJ, Theil K, Vucikuja S, Aichele P,: Effector T-cell differentiation during viral and bacterial infections: Role of direct IL-12 signals for cell fate decision of CD8(+) T cells.
    Eur J Immunol, 2009; 39 (7): 1774-1783
  • Vetter M, Hofer MJ, Roth E, Pircher H, Pagenstecher A: Intracerebral interleukin 12 induces glioma rejection in the brain predominantly by CD8+ T cells and independently of interferon-gamma.
    Journal of Neuropathology and Experimental
    Neurology, 2009; 68 (5): 525-534
  • Li Y, Hofmann M, Wang Q, Teng L, Chlewicki LK, Pircher H, Mariuzza RA: Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition.
    Immunity, 2009; 31 (1): 35-46
  • Bengsch B, Seigel B, Ruhl M, Timm J, Kuntz M, Blum H E, Pircher H., Thimme R: Coexpression of PD-1,2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation.
    Plos Pathog, 2010; 6 (6) (online): e1000947
  • Rosenits K, Keppler S, Vucikuja S, Aichele P.: T cells acquire cell surface determinants of APC via in vivo trogocytosis during viral infections.
    Eur J Immunol, 2010; 40: 3450-3457
  • Gründemann C, Schwartzkopff S, Koschella M, Schweier M, Peters C, Voehringer D, Pircher H.: The NK receptor KLRG1 is dispensable for virus-induced NK and CD8+ T-cell differentiation and function in vivo.
    Eur J Immunol, 2010; 40: 1303-1314
  • Hofmann, M., and H. Pircher. 2011. E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands.
    Proc Natl Acad Sci U S A 108:16741-6.
  • Spielmann, G., B. K. McFarlin, D. P. O'Connor, P. J. Smith, H. Pircher, and R. J. Simpson. 2011. Aerobic fitness is associated with lower proportions of senescent blood T-cells in man.
    Brain Behav Immun 25:1521-9.
  • Keppler, S. J., and P. Aichele. 2011. Signal 3 requirement for memory CD8+ T-cell activation is determined by the infectious pathogen.
    Eur J Immunol 41:3176-3186.
  •  Mueller, K., A. von Mässenhausen, U. Aichele, L. Stärck, M. Leisegang, W. Uckert, and H. Pircher. 2012. Protective capacity of virus-specific T cell receptor (TCR)-transduced CD8 T cells in vivo. J.Virol.86:10866-10869
  • Hofmann, M., O. Schweier, and H. Pircher. 2012. Different inhibitory capacities of human and mouse KLRG1 are linked to distinct disulfide-mediated oligomerizations.
    Eur J Immunol. 42:284-2490
  • Ganal, S. C., S. L. Sanos, C. Kallfass, K. Oberle, C. Johner, C. Kirschning, S. Lienenklaus, S. Weiss, P. Staeheli, P. Aichele, and A. Diefenbach. 2012. Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota.
    Immunity 37:171-186
  • Keppler, S. J., K. Rosenits, T. Koegl, S. Vucikuja, and P. Aichele. 2012. Signal 3 cytokines as modulators of primary immune responses during infections: the interplay of type I IFN and IL-12 in CD8 T cell responses.
    PLoS One 7:e40865.
  • Cyktor, J. C., B. Carruthers, P. Stromberg, E. Flano, H. Pircher, and J. Turner. 2013. Killer cell lectin-like receptor G1 deficiency significantly enhances survival after Mycobacterium tuberculosis infection.
    Infect Immun 81:1090-1099.
  • Hofmann, M., A. Oschowitzer, S. R. Kurzhals, C. C. Kruger, and H. Pircher. 2013. Thymus-resident memory CD8+ T cells mediate local immunity.
    Eur J Immunol 43:2295-2304.
  • Jessen, B., S. F. Bode, S. Ammann, S. Chakravorty, G. Davies, J. Diestelhorst, M. Frei-Jones, W. A. Gahl, B. R. Gochuico, M. Griese, G. Griffiths, G. Janka, C. Klein, T. Kogl, K. Kurnik, K. Lehmberg, A. Maul-Pavicic, A. D. Mumford, D. Pace, N. Parvaneh, N. Rezaei, G. de Saint Basile, A. Schmitt-Graeff, K. Schwarz, G. T. Karasu, B. Zieger, U. Zur Stadt, P. Aichele, and S. Ehl. 2013. The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2.
    Blood 121:2943-2951.
  • Jessen, B., T. Kögl, F. E. Sepulveda, G. de Saint Basile, P. Aichele, and S. Ehl. 2013. Graded defects in cytotoxicity determine severity of hemophagocytic lymphohistiocytosis in humans and mice.
    Front Immunol 4:448.
  • Kögl, T., J. Muller, B. Jessen, A. Schmitt-Graeff, G. Janka, S. Ehl, U. zur Stadt, and P. Aichele. 2013. Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease.
    Blood 121:604-613.
  • Spielmann, G., C. M. Bollard, A. B. Bigley, P. J. Hanley, J. W. Blaney, E. C. Lavoy, H. Pircher, and R. J. Simpson. 2013. The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans.
    Brain Behav Immun.
  • Straub, T., O. Schweier, M. Bruns, F. Nimmerjahn, A. Waisman, and H. Pircher. 2013. Nucleoprotein-specific nonneutralizing antibodies speed up LCMV elimination independently of complement and FcgammaR.
    Eur J Immunol 43:2338-2348. 
  • Bauer, G., S. Bereswill, P. Aichele, and E. Glocker. 2014. Helicobacter pylori protects oncogenically transformed cells from reactive oxygen species-mediated intercellular induction of apoptosis.
    Carcinogenesis 35:1582-1591.
  • Edele, F., J. C. Dudda, E. Bachtanian, T. Jakob, H. Pircher, and S. F. Martin. 2014. Efficiency of dendritic cell vaccination against B16 melanoma depends on the immunization route.
    PLoS One 9:e105266.
  • Gentle, I. E., I. Moelter, N. Lechler, S. Bambach, S. Vucikuja, G. Hacker, and P. Aichele. 2014. Inhibitors of apoptosis proteins (IAPs) are required for effective T-cell expansion/survival during antiviral immunity in mice.
    Blood 123:659-668.
  • Schweier, O., M. Hofmann, and H. Pircher. 2014. KLRG1 activity is regulated by association with the transferrin receptor.
    Eur J Immunol 44:1851-1856.
  • Spielmann, G., C. M. Bollard, A. B. Bigley, P. J. Hanley, J. W. Blaney, E. C. LaVoy, H. Pircher, and R. J. Simpson. 2014. The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans.
    Brain Behav Immun 39:142-151.
  • Starck, L., K. Popp, H. Pircher, and W. Uckert. 2014. Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell derived T cells.
    J Immunol 192:206-213.

Institute of Immunology

Hermann Herder Straße 11
79104 Freiburg

Tel.:  0761 / 203-6520
Fax.: 0761 / 203-6577


Prof. Dr. sc. nat. Hanspeter Pircher
E- Mail: hanspeter.pircher@uniklinik-freiburg.de