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Welcome to the Institute of Medical Bioinformatics and Systems Medicine (IBSM)

Institute of Medical Bioinformatics and Systems Medicine

Our institute is well embedded into the local, national and international research landscapes. All over, our ambition is to convert high throughput big data into meaningful biological knowledge for improving patient outcome. Researchers with multidisciplinary backgrounds, from biology and bioinformatics to physics and mathematics, are working together to achieve this goal.... more


11 million euros for innovative project for personalized cancer treatment

BMBF funds collaborative project coordinated by Freiburg University Hospital with a total of 11 million euros / New infrastructure to enable secure exchange of biomedical data and facilitate targeted cancer therapies

A new collaborative project on personalized cancer medicine is being funded by the German Federal Ministry of Education and Research (BMBF) with a total of 11 million euros since May 2023 as part of the Medical Informatics Initiative. The joint project PM⁴Onco aims to improve data transfer between oncological centers of excellence for the benefit of tailored therapies. It is coordinated at the University Medical Center Freiburg, for which the Medical Faculty of the University of Freiburg will receive 1.8 million euros of the funding.

"PM⁴Onco is intended to create a permanent infrastructure for the secure exchange of data from clinical and biomedical research. At first, this sounds very technical, but the focus is on people affected by rare and difficult-to-treat cancers - for them, we want to make starting points for targeted treatments easier to find," says Prof. Dr. Dr. Melanie Börries, Director of the Institute for Medical Bioinformatics and Systems Medicine at the University Medical Center Freiburg, who is coordinating the collaborative project. "The precise analysis of genetic alterations in tumors at the respective disease stage is crucial so that molecular tumor boards in the oncological centers of excellence can recommend the most individually appropriate therapy."

The collaborative project combines the expertise and preliminary work of all four consortia of the German government's medical informatics initiative and the oncology centers of excellence in Germany, and also involves the cancer registries. Patient feedback on quality of life and treatment success will also be collected and integrated via questionnaires. A patient representative provides support in an advisory capacity in order to incorporate the perspective of those affected. Regular workshops for patients and citizens are also part of the project, as is the promotion of young scientists.

"PM⁴Onco has the potential to decisively strengthen data-driven personalized medicine in cancer therapy," says Prof. Dr. Lutz Hein, Dean of the Medical Faculty of the University of Freiburg and member of the Board of Directors of Freiburg University Hospital. "Digitization and cross-center data exchange are important prerequisites of top university medicine. We have been very successful in both fields in the past and are pleased to be able to contribute our findings in exchange with other institutions."



Caption: Prof. Dr. Melanie Börries, Director of the Institute for Medical Bioinformatics and Systems Medicine at the University Medical Center Freiburg, coordinates the collaborative project PM⁴Onco.
Image rights: University Medical Center Freiburg

Das Forum Gesundheitsstandort BW 2022

Here is a video summary of the Health Location BW 2022, where Prof. Dr. Dr. Melanie Börries was also present as a speaker:


Newest Publications

Langenbach M, Giesler S, Richtsfeld S, da Costa-Pereira S, Rindlisbacher L, Wertheimer T, Braun LM, Andrieux G, Duquesne S, Pfeifer D, Woessner NM, Menssen HD, Taromi S, Duyster J, Boerries M, Brummer T, Blazar BR, Minguet S, Turko P, Levesque MP, Becher B, Zeiser R., MDM2 inhibition enhances immune checkpoint inhibitor efficacy by increasing IL-15 and MHC class II production.,  Mol Cancer Res. 2023 Apr 18:MCR-22-0898. doi: 10.1158/1541-7786.MCR-22-0898. Online ahead of print. PMID: 37071397

Publication Award 2020

The University of Stuttgart annually awards prizes for outstanding publications from Stuttgart. The publication "Sánchez-González, I., Bobien, A., Molnar, C., Schmid, S., Strotbek, M., Boerries, M., Busch, H., Olayioye, M. A. (2020). miR-149 Suppresses Breast Cancer Metastasis by Blocking Paracrine Interactions with Macrophages. Cancer Research, Tumor Biology and Immunology 80/6, pp. 1330-1341.", authored by Prof. Börries together with colleagues from Stuttgart, has won the publication award 2020.


Medical Informatics Initiative: Strengthening research and advancing healthcare


Dean congratulates: New junior research group as part of the medical informatics initiative

With a funding volume of 1.5 million euros for 5 years, Professor Dr. Dr. Melanie Börries from Freiburg has obtained funding for a junior research group entitled "Developments of clinically-oriented decision support for high-throughput data in personalized medicine", or EkoEstMed for short, as part of the federal government's medical informatics initiative.


10 million euros funding for cross-border digital health initiativ

Baden-Württemberg supports project of the University Medical Centers Freiburg and Mannheim on "Cross-border Digital Health Innovations" (GdGI) within the framework of a German-French-Luxembourgian innovation partnership

Tapping the potential of artificial intelligence (AI) for tailored therapy recommendations and creating innovative platforms for the secure handling of sensitive health data: These are the goals of the project "Cross-border digital health innovations through data-based, AI-driven stratification of complex chronic diseases" (GdGI) of the University Medical Center Freiburg and the University Medical Center Mannheim as part of the international collaborative project CLINNOVA, which involves partners from Germany, France and Luxembourg. The state of Baden-Württemberg is funding the development of digital AI-supported healthcare solutions until the end of 2023 with a total of around 10 million...



Appointed to the scientific committee at the Center for Cancer Registry Data.

On August 31, 2021, the law on the pooling of cancer registry data went into effect.
came into force. In § 4 of the Federal Cancer Registry Data Act (BKRG), it regulates the establishment of a
scientific committee at the Center for Cancer Registry Data (ZfKD) at the Robert Koch Institute.
Institute. This scientific committee has the task of assisting the ZfKD in evaluating applications for the use of cancer registry data.
the evaluation of applications for the use of cancer registry data and in the definition of general
general guidelines for the risk assessment of the data to be made available for research purposes.
data to be made available for research purposes. Prof. Melanie Börries participates in this committee and is appointed pursuant to § 4
Paragraph 4 BKRG, she is appointed to the Scientific Committee for a period of five years with effect from September 15, 2021.


New in the Faculty of Medicine: Frau Prof. Dr. Dr. Melanie Börries

Prof. Dr. Dr. Melanie Börries took up the Professorship of Medical Bioinformatics at the Medical Faculty of the University of Freiburg on 1st June 2019 and has since then also been the director of the Institute of Medical Bioinformatics and Systems Medicine at the Freiburg University Medical Centre. Mehr...

Prof. Dr. Dr. Melanie Börries

Director of the Institute
Institute of Medical Bioinformatics und Systems Medicine (IBSM)
University Hospital Freiburg
Telefon: 0761 270-84671

Assistant to the Director
Miriam von Scheibner
Telefon: 0761 270-84673