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Klinik für Innere Medizin IHämatologie, Onkologie und Stammzelltransplantation

Herausragende Publikationen

2018

Haematologica

Osteoprotective medication in the era of novel agents:     European perspective on values, risks and future solutions.     

Monika Engelhardt, Georg W. Herget, Giulia Graziani, Gabriele Ihorst, Heike Reinhardt,     Stefanie Ajayi, Stefan Knop, and Ralph Wäsch.    

Haematologica 2018 [Epub ahead of print]


Science Translational Medicine

Oncogenic JAK2V617F causes PD-L1 expression mediating immune-escape in myeloproliferative neoplasms

Prestipino A, Emhardt A, Aumann K, O´Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M,  Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholomä M, Shoumariyeh K, Jutzi J, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel F, Kröger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, Bubnoff N, Pearce EL, Zeiser R.

Science Translational Medicine  10, eaam7729 (2018)| zum Artikel

Pressemitteilung Freiburg, 22.02.2018: ==> Tumorzellen legen Immunsystem lahm


Blood

Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset.

Hülsdünker J, Ottmüller, K.J., Neeff H, Koyama M, Gao Z, Thomas, O.S., Follo, M, Al-Ahmad A, Prinz G, Duquesne S, Dierbach H, Kirschnek S, Lämmermann T, Blaser M.J., Fife B.T., Blazar, B.R., Beilhack, A, Hill G.R., Häcker G., Zeiser, R.

Blood 2018;10.1182/blood-2017-10-812891. [Epub ahead of print].

zum Artikel


Nature Medicine

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Mathew NR, Baumgartner F, Braun L, O'Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz H, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Sha O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socié G, Caligiuri MA, Ruggiero E, Bonini C, Häcker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R.

Nature Medicine. 2018 Feb 12. doi: 10.1038/nm.4484. | zum Artikel

s.a.: ==> Erfolgreiche Kombinations-Therapie bei aggressiver Leukämie (20.02.2018) 


Blood

Zeiser R, Sarantopoulos S, Blazar BR.
B-cell targeting in chronic Graft-versus-Host disease.

Blood. 2018 Feb 1. pii: blood-2017-11-784017.

zum Artikel


Blood Journal

Introduction to a review series on strategies to improve GVL effects.

Zeiser R.

Blood. 2018 Jan 22. pii: blood-2017-11-814467. doi: 10.1182/blood-2017-11-814467.

mehr ==>


Blood Journal

Genomic CDKN2A/2B deletions in adult Ph+ ALL are adverse despite allogeneic stem cell transplantation

Pfeiffer H, Raum K, Markovic S, Nowak V, Fey S, Obländer J, Pressler J, Böhm V, Brüggemann M, Wunderle L, Hüttmann A, Wäsch R, Beck J, Stelljes M, Viardot A, Lang F, Hoelzer D, Hofmann WK, Serve H, Weiss C, Goekbuget N, Ottmann OG, Nowak D

Blood, 2018 Jan 18. pii: blood-2017-07-796862. doi: 10.1182/blood-2017-07-796862. | zum Artikel


Nature Communications

Nature Communications

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.

Lipka DB, Witte T, Toth R, Yang J, Wiesenfarth M, Nöllke P, Fischer A, Brocks D, Gu Z, Park J, Strahm B, Wlodarski M, Yoshimi A, Claus R, Lübbert M, Busch H, Boerries M, Hartmann M, Schönung M, Kilik U, Langstein J, Wierzbinska JA, Pabst C, Garg S, Catalá A, De Moerloose B, Dworzak M, Hasle H, Locatelli F, Masetti R, Schmugge M, Smith O, Stary J, Ussowicz M, van den Heuvel-Eibrink MM, Assenov Y, Schlesner M, Niemeyer C, Flotho C, Plass C.

Nat Commun. 2017 Dec 19;8(1):2126 | zum Artikel


The New England Journal of Medicine

The New England Journal of Medicine

Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets.

Zeiser R, Blazar BR. | N Engl J Med. 2017 Dec 28;377(26):2565-2579.


The New England Journal of Medicine

Acute Graft-versus-Host Disease - Biologic Process, Prevention, and Therapy.

Zeiser R, Blazar BR. | N Engl J Med. 2017 Nov 30;377(22):2167-2179.


Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.

Gerboth S, Frittoli E, Palamidessi A, Baltanas FC, Mogjiborahman S, Rappsilber J, Giuliani C, Troglio F, Rolland Y, Pruneri G, Kreutmair S, Pallavicini I, Zobel M, Cinquanta M, Minucci S, Gomez C, Santos E, Illert AL, Scita G.
Leukemia. 2017 Aug 18. doi: 10.1038/leu.2017.267.

www.ncbi.nlm.nih.gov/pubmed/28819285


Long-term outcomes after standard graft-versus-host disease prophylaxis with or without anti-human-T-lymphocyte immunoglobulin in haemopoietic cell transplantation from matched unrelated donors: final results of a randomised controlled trial

Jürgen Finke, Claudia Schmoor, Wolfgang Andreas Bethge, Hellmut Ottinger, Matthias Stelljes, Liisa Volin, Dominik Heim, Hartmut Bertz,Olga Grishina, Gerard Socie
Lancet Haematol
2017;4: e293–301
Full text

Comment | Frédéric Baron

Unrelated donor haemopoietic stem-cell transplantation: ATG or not?

Full text


MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT-signaling in dendritic cells after stem cell transplantation.

Stickel N, Hanke K, Marschner D, Prinz G, Köhler M, Melchinger W, Pfeifer D, Schmitt-Graeff A, Brummer T, Heine A, Brossart P, Wolf D, von Bubnoff N, Finke J, Duyster J, Ferrara J, Salzer U, Zeiser R. 

Leukemia (9 May 2017) | doi:10.1038/leu.2017.137

mehr

High-throughput sequencing for noninvasive disease detection in hematologic malignancies

Florian Scherer, David M. Kurtz, Maximilian Diehn and Ash A. Alizadeh

Blood 2017 :blood-2017-03-735639; doi:

mehr

Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice.

Harlander S, Schönenberger D, Toussaint NC, Prummer M, Catalano A, Brandt L, Moch H, Wild PJ, Frew IJ.

Nature Medicine. 2017 May 29. doi: 10.1038/nm.4343. [Epub ahead of print]

mehr

New Paper by Rouven Hoefflin et al.

  • Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

    Rouven Hoefflin, Bernd Lahrmann, Gregor Warsow, Daniel Hübschmann, Cathleen Spath, Britta Walter, Xin Chen, Luisa Hofer, Stephan Macher-Goeppinger, Yanis Tolstov, Nina Korzeniewski, Anette Duensing, Carsten Grüllich, Dirk Jäger, Sven Perner, Gita Schönberg, Joanne Nyarangi-Dix, Sanjay Isaac, Gencay Hatiboglu, Dogu Teber et al.

    Nature Communications 7, Article number: ncomms11845doi:10.1038/ncomms11845 | Received 21 January 2016 | Accepted 04 May 2016 | Published 13 June 2016

    ==> http://www.nature.com/articles/ncomms11845

Cover image, Blood, April 14, 2016

Publikation AG Zeiser | April 14, 2016; Blood

About the Cover

Logo JEM

The Journal of Experimental Medicine

New Paper by PD Dr. Christine Dierks und Team:

Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression.

Klein C, Zwick A, Kissel S, Forster CU, Pfeifer D, Follo M, Illert AL,Decker S, Benkler T, Pahl H, Oostendorp RA, Aumann K, Duyster J,Dierks C.

J Exp Med. 2016 Feb 8;213(2):273-90. doi: 10.1084/jem.20150556. Epub2016 Feb 1.

2015

Neues GvHD Behandlungs Konzept aus Freiburg

Prof. Zeiser/Prof. von Bubnoff

WOCHENPLAN
Wochenplan

Klinik für Innere Medizin I
KW 22

28.05.2018 - 03.06.2018

Klinik für Innere Medizin I

Klinik für Tumorbiologie

Hämatologie, Onkologie und
Stammzelltransplantation

Hugstetter Straße 55
79106 Freiburg