Herausragende Publikationen
2021
Immunobiology and Immunotherapy| February 4, 2021
Releasing the brake in CAR natural killer cells
Sophia Chen
Blood (2021) 137 (5): 579–581. ►
Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans.
Uhl FM, Chen S, O'Sullivan D, Edwards-Hicks J, Richter G, Haring E, Andrieux G, Halbach S, Apostolova P, Büscher J, Duquesne S, Melchinger W, Sauer B, Shoumariyeh K, Schmitt-Graeff A, Kreutz M, Lübbert M, Duyster J, Brummer T, Boerries M, Madl T, Blazar BR, Groß O, Pearce EL, Zeiser R.
Science Translational Med. 2020 Oct 28;12(567):eabb8969. ►
Glucagon like peptide-2 for Intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans.
Norona J, Apostolova P, Schmidt D, Ihlemann R, Reischmann N, Taylor G, Köhler N, de Heer J, Heeg S, Andrieux G, Siranosian BA, Schmitt-Graeff A, Pfeifer D, Catalano A, Frew I, Proietti M, Grimbacher B, Bulashevska A, Bhatt AS, Brummer T, Clauditz TS, Zabelina T, Kroeger N, Blazar BR, Boerries M, Ayuk F, Zeiser R.
Blood. 2020 Jun 15:blood.2020005957.
► doi.org/10.1182/blood.2020005957
Die Publikation wurde als Cover für das Journal "Blood" ausgewählt und von einem Editorial begleitet: ► https://ashpublications.org/blood/issue/136/12
Herzlichen Glückwunsch!
Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease.
Zeiser R, von Bubnoff N, Butler J, Mohty M, Niederwieser D, Or R, Szer J, Wagner EM, Zuckerman T, Mahuzier B, Xu J, Wilke C, Gandhi KK, Socié G, for the REACH2 Trial Group.
The New England Journal of Medicine Apr 22. ► doi: 10.1056/NEJMoa1917635 (2020).
Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure.
Kreutmair S, Erlacher M, Andrieux G, Istvanffy R, Mueller-Rudorf A, Zwick M, Rückert T, Pantic M, Poggio T, Shoumariyeh K, Mueller TA, Kawaguchi H, Follo M, Klingeberg C, Wlodarski M, Baumann I, Pfeifer D, Kulinski M, Rudelius M, Lemeer S, Kuster B, Dierks C, Peschel C, Cabezas-Wallscheid N, Duque-Afonso J, Zeiser R, Cleary ML, Schindler D, Schmitt-Graeff A, Boerries M, Niemeyer CM, Oostendorp RA, Duyster J, Illert AL.
J Clin Invest. 2020 Apr 27. pii: 126215. ► doi: 10.1172/JCI126215.
TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia
Szenes E, Härzschel A, Decker S, Tissino E, Pischeli J, Gutjahr JC, Kissel S, Pennisi S, Höpner JP, Egle A, Zaborsky N, Dierks C, Follo M, Chigaev A, Zucchetto A, Greil R, Gattei V, Hartmann TN
Leukemia. 2020 Feb 21. doi: 10.1038/s41375-020-0759-3. [Epub ahead of print]
Extracorporeal Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy.
Apostolova P, Unger S, von Bubnoff D, Meiss F, Becher B, Zeiser R.
N Engl J Med. 2020 Jan 16;382(3):294-296.
► www.nejm.org/doi/full/10.1056/NEJMc1912274
CD49d promotes disease progression in chronic lymphocytic leukemia: new insights from CD49d bimodal expression
Tissino E, Pozzo F, Benedetti D, Caldana C, Bittolo T, Rossi FM, Bomben R, Nanni P, Chivilò H, Cattarossi I, Zaina E, Norris K, Polesel J, Gentile M, Tripepi G, Moia R, Santinelli E, Innocenti I, Olivieri J, D'Arena G, Laurenti L, Zaja F, Pozzato G, Chiarenza A, Di Raimondo F, Rossi D, Pepper C, Hartmann TN, Gaidano G, Del Poeta G, Gattei V, Zucchetto A.
Blood. 2020 Jan 31. pii: blood.2019003179. doi: 10.1182/blood.2019003179. [Epub ahead of print]
► ashpublications.org/blood/article-lookup/doi/10.1182/blood.2019003179
Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia.
Mathew N, Vinnakota JM, Apostolova P, Erny D, Hamarsheh S, Andrieux G, Kim JS, Hanke K, Goldmann T, Chappell-Maor L, El-Khawanky N, Ihorst G, Schmidt D, Duyster J, Finke J, Blank T, Boerries M, Blazar BR, Jung S, Prinz M, Zeiser R.
J Clin Invest. 2019 Dec 17. pii: 130272. doi: 10.1172/JCI130272.
Blood. 2019 Sep 19.
B-cell specific IRF4 deletion accelerates Chronic Lymphocytic Leukemia development by enhanced tumor immune evasion.
Asslaber D, Qi Y, Maeding N, Steiner M, Denk U, Höpner JP, Hartmann TN, Zaborsky N, Greil R, Egle A.
Blood. 2019 Sep 19. pii: blood.2019000973. doi: 10.1182/blood.2019000973. [Epub ahead of print]
Blood. 2019 Sep 18.
Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GvHD.
Koehn BH, Saha A, McDonald-Hyman C, Loschi M, Thangavelu G, Ma L, Zaiken M, Dysthe J, Krepps W, Panthera J, Hippen K, Jameson SC, Miller JS, Cooper MA, Farady CJ, Iwawaki T, Ting JP, Serody JS, Murphy WJ, Hill GR, Murray PJ, Bronte V, Munn DH, Zeiser R, Blazar BR.
Blood. 2019 Sep 18. pii: blood.2019001950. doi: 10.1182/blood.2019001950.
Proc Natl Acad Sci U S A. | 2019 Sep 16.
Immunization against poly-N-acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity.
Hülsdünker J, Thomas OS, Haring E, Unger S, Gonzalo Núñez N, Tugues S, Gao Z, Duquesne S, Cywes-Bentley C, Oyardi O, Kirschnek S, Schmitt-Graeff A, Pabst O, Koenecke C, Duyster J, Apostolova P, Blaser MJ, Becher B, Pier GB, Häcker G, Zeiser R.
Proc Natl Acad Sci U S A. 2019 Sep 16. → zum Artikel
Blood Journal | 06-2019
NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia
Rudorf A, Müller TA, Klingeberg C, Kreutmair S, Poggio T, Gorantla SP, Rückert T, Schmitt-Graeff A, Gengenbacher A, Paschka P, Baldus C, Zeiser R, Vassiliou GS, Bradley A, Duyster J, Illert AL.
Blood. 2019 Jun 11. → zum Artikel
Blood Journal | 02-2019
Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations
Jonas Samuel Jutzi, Titiksha Basu, Maximilian Pellmann, Sandra Kaiser, Doris Steinemann, Mathijs A. Sanders, Adil S.A. Hinai, Annelieke Zeilemaker, Sarolta Bojtine Kovacs, Christoph Koellerer, Jenny Ostendorp, Konrad Aumann, Wei Wang, Emmanuel Raffoux, Bruno Cassinat, Lars Bullinger, Brigitte Schlegelberger, Peter J.M. Valk and Heike L. Pahl
Blood, [in press] ==> www.bloodjournal.org/
Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction
Kurtz DM*, Esfahani MS*, Scherer F*, Soo J, Jin MC, Liu CL, Newman AM, Dührsen U, Hüttmann A, Casasnovas O, Westin JR, Ritgen M, Böttcher S, Langerak AW, Roschweski M, Wilson WH, Gaidano G, Rossi D, Bahlo J, Hallek M, Tibshirani R, Diehn M, Alizadeh AA
* Co-first Autor
Cancer Research
miR-146a controls immune response in the melanoma microenvironment
Justin Mastroianni, Natalie Stickel, Hana Andrlová, Kathrin Hanke, Wolfgang Melchinger, Sandra Duquesne, Dominik Schmidt, Martina Falk, Geoffroy Andrieux, Dietmar Pfeifer, Heide Dierbach, Annette Schmitt-Graeff, Frank Meiss, Melanie Boerries and Robert Zeiser
Cancer Res. 2018 Nov 13. pii: canres.1397.2018. doi: 10.1158/0008-5472.CAN-18-1397. [Epub ahead of print]
Blood Journal
Genomic CDKN2A/2B deletions in adult Ph+ ALL are adverse despite allogeneic stem cell transplantation
Pfeiffer H, Raum K, Markovic S, Nowak V, Fey S, Obländer J, Pressler J, Böhm V, Brüggemann M, Wunderle L, Hüttmann A, Wäsch R, Beck J, Stelljes M, Viardot A, Lang F, Hoelzer D, Hofmann WK, Serve H, Weiss C, Goekbuget N, Ottmann OG, Nowak D
Blood, 2018 Jan 18. pii: blood-2017-07-796862. doi: 10.1182/blood-2017-07-796862. | zum Artikel
Nature Communications
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.
Lipka DB, Witte T, Toth R, Yang J, Wiesenfarth M, Nöllke P, Fischer A, Brocks D, Gu Z, Park J, Strahm B, Wlodarski M, Yoshimi A, Claus R, Lübbert M, Busch H, Boerries M, Hartmann M, Schönung M, Kilik U, Langstein J, Wierzbinska JA, Pabst C, Garg S, Catalá A, De Moerloose B, Dworzak M, Hasle H, Locatelli F, Masetti R, Schmugge M, Smith O, Stary J, Ussowicz M, van den Heuvel-Eibrink MM, Assenov Y, Schlesner M, Niemeyer C, Flotho C, Plass C.
Nat Commun. 2017 Dec 19;8(1):2126 | zum Artikel
The New England Journal of Medicine
Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets.
Zeiser R, Blazar BR. | N Engl J Med. 2017 Dec 28;377(26):2565-2579.
Blood Journal
Introduction to a review series on strategies to improve GVL effects.
Zeiser R.
Blood. 2018 Jan 22. pii: blood-2017-11-814467. doi: 10.1182/blood-2017-11-814467.
Blood
Zeiser R, Sarantopoulos S, Blazar BR.
B-cell targeting in chronic Graft-versus-Host disease.
Blood. 2018 Feb 1. pii: blood-2017-11-784017.
Blood
Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset.
Hülsdünker J, Ottmüller, K.J., Neeff H, Koyama M, Gao Z, Thomas, O.S., Follo, M, Al-Ahmad A, Prinz G, Duquesne S, Dierbach H, Kirschnek S, Lämmermann T, Blaser M.J., Fife B.T., Blazar, B.R., Beilhack, A, Hill G.R., Häcker G., Zeiser, R.
Blood 2018;10.1182/blood-2017-10-812891. [Epub ahead of print].
Nature Medicine
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.
Mathew NR, Baumgartner F, Braun L, O'Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz H, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Sha O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socié G, Caligiuri MA, Ruggiero E, Bonini C, Häcker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R.
Nature Medicine. 2018 Feb 12. doi: 10.1038/nm.4484. | zum Artikel
s.a.: ==> Erfolgreiche Kombinations-Therapie bei aggressiver Leukämie (20.02.2018)
Blood
Cytopenia levels for aiding establishment of the diagnosis of myelodysplastic syndromes.
Greenberg PL, Tuechler H, Schanz J, Sanz G, Garcia-Manero G, Solé F, Bennett JM, Bowen D, Fenaux P, Dreyfus F, Kantarjian H, Kuendgen A, Levis A, Malcovati L, Cazzola M, Cermak J, Fonatsch C, Le Beau MM, Slovak ML, Krieger O, Luebbert M, Maciejewski J, Magalhaes SM, Miyazaki Y, Pfeilstöcker M, Sekeres M, Sperr WR, Stauder R, Tauro S, Valent P, Vallespi T, van de Loosdrecht AA, Germing U, Haase D.
Blood. 2016 Oct 20;128(16):2096-2097. doi: 10.1182/blood-2016-07-728766.
Blood
A novel disease-causing synonymous exonic mutation in GATA2 affecting RNA splicing.
Wehr C, Grotius K, Casadei S, Bleckmann D, Bode SFN, Frye BC, Seidl M, Gulsuner S, King MC, Percival MB, Pritchard CC, Walsh T, Wu D, Keel S, Salzer U.
Blood 2018 Jul 20. pii: blood-2018-03-837336. doi: 10.1182/blood-2018-03-837336.
[Epub ahead of print] No abstract available. PMID: 30030275
Blood
Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms
Jan C. Peeken, Jonas S. Jutzi, Julius Wehrle, Christoph Koellerer, Hans F. Staehle, Heiko Becker, Elias Schoenwandt, Thalia S. Seeger, Daniel H. Schanne, Monika Gothwal, Christopher J. Ott, Albert Gründer and Heike L. Pahl
Blood 2018 131:2065-2073; doi: https://doi.org/10.1182/blood-2017-10-810622
Science Translational Medicine
Oncogenic JAK2V617F causes PD-L1 expression mediating immune-escape in myeloproliferative neoplasms
Prestipino A, Emhardt A, Aumann K, O´Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M, Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholomä M, Shoumariyeh K, Jutzi J, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel F, Kröger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, Bubnoff N, Pearce EL, Zeiser R.
Science Translational Medicine 10, eaam7729 (2018)| zum Artikel
Pressemitteilung Freiburg, 22.02.2018: ==> Tumorzellen legen Immunsystem lahm
Haematologica
Osteoprotective medication in the era of novel agents: European perspective on values, risks and future solutions.
Monika Engelhardt, Georg W. Herget, Giulia Graziani, Gabriele Ihorst, Heike Reinhardt, Stefanie Ajayi, Stefan Knop, and Ralph Wäsch.
Haematologica 2018 [Epub ahead of print]
Acute Graft-versus-Host Disease - Biologic Process, Prevention, and Therapy.
Zeiser R, Blazar BR. | N Engl J Med. 2017 Nov 30;377(22):2167-2179.
Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.
Gerboth S, Frittoli E, Palamidessi A, Baltanas FC, Mogjiborahman S, Rappsilber J, Giuliani C, Troglio F, Rolland Y, Pruneri G, Kreutmair S, Pallavicini I, Zobel M, Cinquanta M, Minucci S, Gomez C, Santos E, Illert AL, Scita G.
Leukemia. 2017 Aug 18. doi: 10.1038/leu.2017.267.
www.ncbi.nlm.nih.gov/pubmed/28819285
Long-term outcomes after standard graft-versus-host disease prophylaxis with or without anti-human-T-lymphocyte immunoglobulin in haemopoietic cell transplantation from matched unrelated donors: final results of a randomised controlled trial
Jürgen Finke, Claudia Schmoor, Wolfgang Andreas Bethge, Hellmut Ottinger, Matthias Stelljes, Liisa Volin, Dominik Heim, Hartmut Bertz,Olga Grishina, Gerard Socie
Lancet Haematol 2017;4: e293–301
Full text
Comment | Frédéric Baron
Unrelated donor haemopoietic stem-cell transplantation: ATG or not?
MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT-signaling in dendritic cells after stem cell transplantation.
Stickel N, Hanke K, Marschner D, Prinz G, Köhler M, Melchinger W, Pfeifer D, Schmitt-Graeff A, Brummer T, Heine A, Brossart P, Wolf D, von Bubnoff N, Finke J, Duyster J, Ferrara J, Salzer U, Zeiser R.
Leukemia (9 May 2017) | doi:10.1038/leu.2017.137
High-throughput sequencing for noninvasive disease detection in hematologic malignancies
Florian Scherer, David M. Kurtz, Maximilian Diehn and Ash A. Alizadeh
Blood 2017 :blood-2017-03-735639; doi:
Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice.
Harlander S, Schönenberger D, Toussaint NC, Prummer M, Catalano A, Brandt L, Moch H, Wild PJ, Frew IJ.
Nature Medicine. 2017 May 29. doi: 10.1038/nm.4343. [Epub ahead of print]
New Paper by Rouven Hoefflin et al.
- Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity
Rouven Hoefflin, Bernd Lahrmann, Gregor Warsow, Daniel Hübschmann, Cathleen Spath, Britta Walter, Xin Chen, Luisa Hofer, Stephan Macher-Goeppinger, Yanis Tolstov, Nina Korzeniewski, Anette Duensing, Carsten Grüllich, Dirk Jäger, Sven Perner, Gita Schönberg, Joanne Nyarangi-Dix, Sanjay Isaac, Gencay Hatiboglu, Dogu Teber et al.
Nature Communications 7, Article number: ncomms11845doi:10.1038/ncomms11845 | Received 21 January 2016 | Accepted 04 May 2016 | Published 13 June 2016
==> http://www.nature.com/articles/ncomms11845
Cover image, Blood, April 14, 2016
Publikation AG Zeiser | April 14, 2016; Blood
The Journal of Experimental Medicine
New Paper by PD Dr. Christine Dierks und Team:
Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression. ⇒
Klein C, Zwick A, Kissel S, Forster CU, Pfeifer D, Follo M, Illert AL,Decker S, Benkler T, Pahl H, Oostendorp RA, Aumann K, Duyster J,Dierks C.
J Exp Med. 2016 Feb 8;213(2):273-90. doi: 10.1084/jem.20150556. Epub2016 Feb 1.
ASBMT eNews
Ruxolitinib is Potential Corticosteroid-Refractory GVHD Therapy [PDF]
Original Article ↓
Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey
Leukemia (2015) 29, 2062–2068; doi:10.1038/leu.2015.212;
2015
Neues GvHD Behandlungs Konzept aus Freiburg
Prof. Zeiser/Prof. von Bubnoff
Klinik für Innere Medizin I
KW 08
22.02.2021 - 28.02.2021
Klinik für Innere Medizin I
Klinik für Tumorbiologie
Hämatologie, Onkologie und
Stammzelltransplantation
Hugstetter Straße 55
79106 Freiburg