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Klinik für Innere Medizin IHämatologie, Onkologie und Stammzelltransplantation

Herausragende Publikationen

2019

Proc Natl Acad Sci U S A. | 2019 Sep 16.

Immunization against poly-N-acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity.

Hülsdünker J, Thomas OS, Haring E, Unger S, Gonzalo Núñez N, Tugues S, Gao Z, Duquesne S, Cywes-Bentley C, Oyardi O, Kirschnek S, Schmitt-Graeff A, Pabst O, Koenecke C, Duyster J, Apostolova P, Blaser MJ, Becher B, Pier GB, Häcker G, Zeiser R.

Proc Natl Acad Sci U S A. 2019 Sep 16. → zum Artikel


Blood Journal

Blood Journal | 09-2019

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GvHD.

Koehn BH, Saha A, McDonald-Hyman C, Loschi M, Thangavelu G, Ma L, Zaiken M, Dysthe J, Krepps W, Panthera J, Hippen K, Jameson SC, Miller JS, Cooper MA, Farady CJ, Iwawaki T, Ting JP, Serody JS, Murphy WJ, Hill GR, Murray PJ, Bronte V, Munn DH, Zeiser R, Blazar BR.

Blood. 2019 Sep 18. → zum Artikel


Cell | Jun 27, 2019
Cell-Journal

Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction

Kurtz DM*, Esfahani MS*, Scherer F*, Soo J, Jin MC, Liu CL, Newman AM, Dührsen U, Hüttmann A, Casasnovas O, Westin JR, Ritgen M, Böttcher S, Langerak AW, Roschweski M, Wilson WH, Gaidano G, Rossi D, Bahlo J, Hallek M, Tibshirani R, Diehn M, Alizadeh AA
* Co-first Autor

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Blood Journal

Blood Journal | 06-2019

NPM1c alters FLT3-D835Y localization and signaling in acute myeloid leukemia

Rudorf A, Müller TA, Klingeberg C, Kreutmair S, Poggio T, Gorantla SP, Rückert T, Schmitt-Graeff A, Gengenbacher A, Paschka P, Baldus C, Zeiser R, Vassiliou GS, Bradley A, Duyster J, Illert AL.

Blood. 2019 Jun 11. → zum Artikel


Blood Journal

Blood Journal | 02-2019

Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations

Jonas Samuel Jutzi, Titiksha Basu, Maximilian Pellmann, Sandra Kaiser, Doris Steinemann, Mathijs A. Sanders, Adil S.A. Hinai, Annelieke Zeilemaker, Sarolta Bojtine Kovacs, Christoph Koellerer, Jenny Ostendorp, Konrad Aumann, Wei Wang, Emmanuel Raffoux, Bruno Cassinat, Lars Bullinger, Brigitte Schlegelberger, Peter J.M. Valk and Heike L. Pahl

Blood, [in press] ==> www.bloodjournal.org/


Cancer Research

miR-146a controls immune response in the melanoma microenvironment

Justin Mastroianni, Natalie Stickel, Hana Andrlová, Kathrin Hanke, Wolfgang Melchinger, Sandra Duquesne, Dominik Schmidt, Martina Falk, Geoffroy Andrieux, Dietmar Pfeifer, Heide Dierbach, Annette Schmitt-Graeff, Frank Meiss, Melanie Boerries and Robert Zeiser

Cancer Res. 2018 Nov 13. pii: canres.1397.2018. doi: 10.1158/0008-5472.CAN-18-1397. [Epub ahead of print]

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Blood Journal

Genomic CDKN2A/2B deletions in adult Ph+ ALL are adverse despite allogeneic stem cell transplantation

Pfeiffer H, Raum K, Markovic S, Nowak V, Fey S, Obländer J, Pressler J, Böhm V, Brüggemann M, Wunderle L, Hüttmann A, Wäsch R, Beck J, Stelljes M, Viardot A, Lang F, Hoelzer D, Hofmann WK, Serve H, Weiss C, Goekbuget N, Ottmann OG, Nowak D

Blood, 2018 Jan 18. pii: blood-2017-07-796862. doi: 10.1182/blood-2017-07-796862. | zum Artikel


Nature Communications

Nature Communications

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.

Lipka DB, Witte T, Toth R, Yang J, Wiesenfarth M, Nöllke P, Fischer A, Brocks D, Gu Z, Park J, Strahm B, Wlodarski M, Yoshimi A, Claus R, Lübbert M, Busch H, Boerries M, Hartmann M, Schönung M, Kilik U, Langstein J, Wierzbinska JA, Pabst C, Garg S, Catalá A, De Moerloose B, Dworzak M, Hasle H, Locatelli F, Masetti R, Schmugge M, Smith O, Stary J, Ussowicz M, van den Heuvel-Eibrink MM, Assenov Y, Schlesner M, Niemeyer C, Flotho C, Plass C.

Nat Commun. 2017 Dec 19;8(1):2126 | zum Artikel


The New England Journal of Medicine

The New England Journal of Medicine

Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets.

Zeiser R, Blazar BR. | N Engl J Med. 2017 Dec 28;377(26):2565-2579.


Blood Journal

Introduction to a review series on strategies to improve GVL effects.

Zeiser R.

Blood. 2018 Jan 22. pii: blood-2017-11-814467. doi: 10.1182/blood-2017-11-814467.

mehr ==>


Blood

Zeiser R, Sarantopoulos S, Blazar BR.
B-cell targeting in chronic Graft-versus-Host disease.

Blood. 2018 Feb 1. pii: blood-2017-11-784017.

zum Artikel


Blood

Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset.

Hülsdünker J, Ottmüller, K.J., Neeff H, Koyama M, Gao Z, Thomas, O.S., Follo, M, Al-Ahmad A, Prinz G, Duquesne S, Dierbach H, Kirschnek S, Lämmermann T, Blaser M.J., Fife B.T., Blazar, B.R., Beilhack, A, Hill G.R., Häcker G., Zeiser, R.

Blood 2018;10.1182/blood-2017-10-812891. [Epub ahead of print].

zum Artikel


Nature Medicine

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

Mathew NR, Baumgartner F, Braun L, O'Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz H, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Sha O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socié G, Caligiuri MA, Ruggiero E, Bonini C, Häcker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R.

Nature Medicine. 2018 Feb 12. doi: 10.1038/nm.4484. | zum Artikel

s.a.: ==> Erfolgreiche Kombinations-Therapie bei aggressiver Leukämie (20.02.2018) 


Blood

Cytopenia levels for aiding establishment of the diagnosis of myelodysplastic syndromes.

Greenberg PL, Tuechler H, Schanz J, Sanz G, Garcia-Manero G, Solé F, Bennett JM, Bowen D, Fenaux P, Dreyfus F, Kantarjian H, Kuendgen A, Levis A, Malcovati L, Cazzola M, Cermak J, Fonatsch C, Le Beau MM, Slovak ML, Krieger O, Luebbert M, Maciejewski J, Magalhaes SM, Miyazaki Y, Pfeilstöcker M, Sekeres M, Sperr WR, Stauder R, Tauro S, Valent P, Vallespi T, van de Loosdrecht AA, Germing U, Haase D.

Blood. 2016 Oct 20;128(16):2096-2097. doi: 10.1182/blood-2016-07-728766.

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Blood

A novel disease-causing synonymous exonic mutation in GATA2 affecting RNA splicing.

Wehr C, Grotius K, Casadei S, Bleckmann D, Bode SFN, Frye BC, Seidl M, Gulsuner S, King MC, Percival MB, Pritchard CC, Walsh T, Wu D, Keel S, Salzer U.

Blood 2018 Jul 20. pii: blood-2018-03-837336. doi: 10.1182/blood-2018-03-837336.
[Epub ahead of print] No abstract available. PMID: 30030275

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Blood

Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms

Jan C. Peeken, Jonas S. Jutzi, Julius Wehrle, Christoph Koellerer, Hans F. Staehle, Heiko Becker, Elias Schoenwandt, Thalia S. Seeger, Daniel H. Schanne, Monika Gothwal, Christopher J. Ott, Albert Gründer and Heike L. Pahl

Blood 2018 131:2065-2073; doi: https://doi.org/10.1182/blood-2017-10-810622 


Science Translational Medicine

Oncogenic JAK2V617F causes PD-L1 expression mediating immune-escape in myeloproliferative neoplasms

Prestipino A, Emhardt A, Aumann K, O´Sullivan D, Gorantla SP, Duquesne S, Melchinger W, Braun L, Vuckovic S, Boerries M,  Busch H, Halbach S, Pennisi S, Poggio T, Apostolova P, Veratti P, Hettich M, Niedermann G, Bartholomä M, Shoumariyeh K, Jutzi J, Wehrle J, Dierks C, Becker H, Schmitt-Graeff A, Follo M, Pfeifer D, Rohr J, Fuchs S, Ehl S, Hartl FA, Minguet S, Miething C, Heidel F, Kröger N, Triviai I, Brummer T, Finke J, Illert AL, Ruggiero E, Bonini C, Duyster J, Pahl HL, Lane SW, Hill GR, Blazar BR, Bubnoff N, Pearce EL, Zeiser R.

Science Translational Medicine  10, eaam7729 (2018)| zum Artikel

Pressemitteilung Freiburg, 22.02.2018: ==> Tumorzellen legen Immunsystem lahm


Haematologica

Osteoprotective medication in the era of novel agents:     European perspective on values, risks and future solutions.     

Monika Engelhardt, Georg W. Herget, Giulia Graziani, Gabriele Ihorst, Heike Reinhardt,     Stefanie Ajayi, Stefan Knop, and Ralph Wäsch.    

Haematologica 2018 [Epub ahead of print]


The New England Journal of Medicine

Acute Graft-versus-Host Disease - Biologic Process, Prevention, and Therapy.

Zeiser R, Blazar BR. | N Engl J Med. 2017 Nov 30;377(22):2167-2179.


Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.

Gerboth S, Frittoli E, Palamidessi A, Baltanas FC, Mogjiborahman S, Rappsilber J, Giuliani C, Troglio F, Rolland Y, Pruneri G, Kreutmair S, Pallavicini I, Zobel M, Cinquanta M, Minucci S, Gomez C, Santos E, Illert AL, Scita G.
Leukemia. 2017 Aug 18. doi: 10.1038/leu.2017.267.

www.ncbi.nlm.nih.gov/pubmed/28819285


Long-term outcomes after standard graft-versus-host disease prophylaxis with or without anti-human-T-lymphocyte immunoglobulin in haemopoietic cell transplantation from matched unrelated donors: final results of a randomised controlled trial

Jürgen Finke, Claudia Schmoor, Wolfgang Andreas Bethge, Hellmut Ottinger, Matthias Stelljes, Liisa Volin, Dominik Heim, Hartmut Bertz,Olga Grishina, Gerard Socie
Lancet Haematol
2017;4: e293–301
Full text

Comment | Frédéric Baron

Unrelated donor haemopoietic stem-cell transplantation: ATG or not?

Full text


MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT-signaling in dendritic cells after stem cell transplantation.

Stickel N, Hanke K, Marschner D, Prinz G, Köhler M, Melchinger W, Pfeifer D, Schmitt-Graeff A, Brummer T, Heine A, Brossart P, Wolf D, von Bubnoff N, Finke J, Duyster J, Ferrara J, Salzer U, Zeiser R. 

Leukemia (9 May 2017) | doi:10.1038/leu.2017.137

mehr

High-throughput sequencing for noninvasive disease detection in hematologic malignancies

Florian Scherer, David M. Kurtz, Maximilian Diehn and Ash A. Alizadeh

Blood 2017 :blood-2017-03-735639; doi:

mehr

Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice.

Harlander S, Schönenberger D, Toussaint NC, Prummer M, Catalano A, Brandt L, Moch H, Wild PJ, Frew IJ.

Nature Medicine. 2017 May 29. doi: 10.1038/nm.4343. [Epub ahead of print]

mehr

New Paper by Rouven Hoefflin et al.

  • Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

    Rouven Hoefflin, Bernd Lahrmann, Gregor Warsow, Daniel Hübschmann, Cathleen Spath, Britta Walter, Xin Chen, Luisa Hofer, Stephan Macher-Goeppinger, Yanis Tolstov, Nina Korzeniewski, Anette Duensing, Carsten Grüllich, Dirk Jäger, Sven Perner, Gita Schönberg, Joanne Nyarangi-Dix, Sanjay Isaac, Gencay Hatiboglu, Dogu Teber et al.

    Nature Communications 7, Article number: ncomms11845doi:10.1038/ncomms11845 | Received 21 January 2016 | Accepted 04 May 2016 | Published 13 June 2016

    ==> http://www.nature.com/articles/ncomms11845

Cover image, Blood, April 14, 2016

Publikation AG Zeiser | April 14, 2016; Blood

About the Cover

Logo JEM

The Journal of Experimental Medicine

New Paper by PD Dr. Christine Dierks und Team:

Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression.

Klein C, Zwick A, Kissel S, Forster CU, Pfeifer D, Follo M, Illert AL,Decker S, Benkler T, Pahl H, Oostendorp RA, Aumann K, Duyster J,Dierks C.

J Exp Med. 2016 Feb 8;213(2):273-90. doi: 10.1084/jem.20150556. Epub2016 Feb 1.

2015

Neues GvHD Behandlungs Konzept aus Freiburg

Prof. Zeiser/Prof. von Bubnoff

WOCHENPLAN
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Klinik für Innere Medizin I

KW 41
07.10.2019 - 13.10.2019

Klinik für Innere Medizin I

Klinik für Tumorbiologie

Hämatologie, Onkologie und
Stammzelltransplantation

Hugstetter Straße 55
79106 Freiburg