Department of Radiology - Medical Physics

Prof. Dr. Jan-Bernd Hövener

Head, Section for Biomedical Imaging and MOIN CC
Head, Emmy Noether Group Molecular and Metabolic MRI

Section Biomedical Imaging, MOIN CC
Am Botanischen Garten 14
D-24118 Kiel

phone:  +49 (0) 431 880-5832
fax:       +49 (0) 431 880-5852

Office Freiburg
Breisachser Straße 60a,
D-79106 Freiburg

phone:  +49 (0) 761 270-93910
fax:       +49 (0) 431 880-38310

email: jan.hoevener@uksh.de
twitter: @jbhoevener

 

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Research Interests:

• Metabolic and Molecular MRI, Hyperpolarization
• Dental MRI
• Translational MRI and MRS
• Short Echo Time MRI of solids (UTE, ZTE)
• Ultra high field MRI

 

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CV

Since 2017
Professor for Translational MRI, Univeristy Medical Center Schleswig-Holstein link

Since 2016              
Vice Chair of MasterOnline Program "Technische Medizin"
U. Freiburg, HS Furtwangen link

President, Int. Society for Magnetic Resonance in Medicine, German Chapter e.V. link        

Habilitation (Venia Legendi) in "Experimental Radiology"
University of Freiburg

Since 2015             
Principal Investigator of the German Consortium for Translational Cancer Research (DKTK)
Freiburg and Heidelberg, Germany link

Since 2014            
Head of Hyperpolarization
Head of Emmy Noether Group "Metabolic and Molecular MRI"
U. Freiburg

Since 2011                      
Lecturer (Dozent) for “Imaging Modalities”  MasterOnline Programm "Technische Medizin"U. Freiburg, HS Furtwangen

2013 - 2014    
Group Leader Hyperpolarization
German Cancer Research Center (DKFZ) and DKTK
Partnersite Freiburg, Germany 

2011 - 2013                    
Tutor for “Radiation Physics”
MasterOnline Programm "Technische Medizin"
U Freiburg, HS Furtwangen

2009 – 2012     
Postdoctoral Fellow, Project Leader Hyperpolarization
Medical Center of the University of Freiburg   

04 / 2006 – 11 / 2008 
PhD in Physics (Dr. rer. nat.)                
Ruprecht-Karls-University,  Germany German Cancer Research Center,
Huntington Medical Research Institutes, California Insitute of Technology
Pasadena, USA, and Heidelberg, Germany

11 / 2005 – 12 / 2005    
Visiting Scientist                                                   
Department of Radiology, New York University, New York City, USA     

1999 – 2005
Diploma in Physics (Dipl. Phys.)     
Münster, Heidelberg, Nice (France)

 

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Publications:

For most recent information, see PubMed or ORCID.

• Schmidt, A. B.; Berner, S.; Schimpf, W.; Müller, C.; Lickert, T.; Schwaderlapp, N.; Knecht, S.; Skinner, J. G.; Dost, A.; Rovedo, P.; Hennig, J.; Elverfeldt, D. von; Hövener, J.-B. Nature Communications 2017, 8, 14535.open access
• Flügge, T.; Hövener, J.-B.; Ludwig, U.; Eisenbeiss, A.-K.; Spittau, B.; Hennig, J.; Schmelzeisen, R.; Nelson, K. Eur Radiol 2016, 26, 4616–4623.
• Rovedo P, Knecht S, Bäumlisberger T, Cremer AL, Duckett SB, Mewis RE, Green GG, Burns M, Rayner PJ, Leibfritz D, Korvink JG, Hennig J, Pütz G, von Elverfeldt D, Hövener JB: "Molecular MRI in the Earth's Magnetic Field Using Continuous Hyperpolarization of a Biomolecule in Water" J Phys Chem B. 2016 Jun 30;120(25):5670-7. doi: 10.1021/acs.jpcb.6b02830.
• Hövener, J.-B.; Bastiaansen, J. A. M.; Comment, A.; Düwel, S.; Ardenkjær-Larsen, J. H. In Small Animal Imaging (Kiessling, Pichler, Eds); Springer: Heidelberg, Dordrecht, London, New York, 2017.
• Schmidt AB, Andrews DL, Rohrbach A, Gohn-Kreuz C, Shatokhin VN, Kiselev VG, Hennig J, von Elverfeldt D, Hövener JB: "Do twisted laser beams evoke nuclear hyperpolarization?" J Magn Reson. 2016 Jul;268:58-67. doi: 10.1016/j.jmr.2016.04.015
• Heidt T, Ehrismann S, Hövener JB, Neudorfer I, Hilgendorf I, Reisert M, Hagemeyer CE, Zirlik A, Reinöhl J, Bode C, Peter K, von Elverfeldt D, von Zur Muhlen C: "Molecular Imaging of Activated Platelets Allows the Detection of Pulmonary Embolism with Magnetic Resonance Imaging", Sci Rep. 2016 May 3;6:25044. doi: 10.1038/srep25044. open access
• Ludwig U, Eisenbeiss AK, Scheifele C, Nelson K, Bock M, Hennig J, von Elverfeldt D, Herdt O, Flügge T, Hövener JB: "Dental MRI using wireless intraoral coils", Sci Rep. 2016 Mar 29;6:23301. doi: 10.1038/srep23301. open access
• Voss P, Ludwig U, Poxleitner P, Bergmaier V, El-Shafi N, von Elverfeldt D, Stadelmann V, Hövener JB, Flügge T: "Evaluation of BP-ONJ in osteopenic and healthy sheep: comparing ZTE-MRI with µCT", Dentomaxillofac Radiol. 2016;45(4):20150250. doi: 10.1259/dmfr.20150250
• Eichhorn T, Ludwig U, Fischer E, Gröbner J, Göpper M, Eisenbeiss AK, Flügge T, Hennig J, von Elverfeldt D, Hövener JB: "Modular Coils with Low Hydrogen Content Especially for MRI of Dry Solids", PLoS One. 2015 Oct 23;10(10):e0139763. doi: 10.1371/journal.pone.0139763 open access

 

2014

• Hövener JB, Knecht S, Schwaderlapp N, Hennig J, von Elverfeldt D: "Continuous re-hyperpolarization of nuclear spins using parahydrogen: theory and experiment", ChemPhysChem, 2014, 15(12):2451-7, DOI:10.1002/cphc.201402177, → open access.
• Ludwig UA, Klausmann F, Baumann S, Honal M, Hövener JB, König D, Deibert P, Büchert M: "Whole-body MRI-based fat quantification: A comparison to air displacement plethysmography", Journal of Magnetic Resonance Imaging, 2014, 40(6):1437-44, DOI:10.1002/jmri.24509, → open access.
• Hövener JB, Schwaderlapp N, Borowiak R, Lickert T, Duckett SB, Mewis RE, Adams RW, Burns MJ, Highton LA, Green GG, Olaru A, Hennig J, von Elverfeldt D: "Toward biocompatible nuclear hyperpolarization using signal amplification by reversible exchange: quantitative in situ spectroscopy and high-field imaging", Analytical Chemistry, 2014, 86(3):1767-74, DOI:10.1021/ac403653q, → open access.

2013

• Hövener J-B, Schwaderlapp N, Lickert T, Duckett SB, Mewis RE, Highton LAR, Kenny, SM, Green GR, Leibfritz D, Korvink J, Hennig J and von Elverdeldt D: "A Hyperpolarized Equilibrium for Magnetic Resonance", nature communications, 2013, 3946, DOI:10.1038/ncomms3946, → open access.
• Ludwig U, Klausmann F, Baumann S, Honal M, Hövener J-B, König D, Deibert P, Büchert M: "Whole-body MRI based fat quantification: A comparison to Air Displacement Plenthysmography", Journal of Magnetic Resonance Imaging, 2013
• Hövener J-B, Bär S, Leupold J, Jenne K, Leibritz D, Hennig J, Duckett S, v. Elverfeldt D: “A continuous-flow, high-throughput and –pressure pH2 converter for hyperpolarization in a clinical setting”, NMR in Biomedicine, 2013, 26(2), p. 124-131, DOI: 10.1002/nbm.2827, → open acess.

2012

• Borowiak R, Schwaderlapp N, Hüthe F, Lickert T, Fischer E, Bär S, Leupold J, Hennig J, v. Elverfeldt D, Hövener J-B: “A Battery-driven, Low-field NMR Unit for Thermally and Hyperpolarized Samples”, Magnetic Resonance Materials in Physics, Biology and Medicine, 2013, 26(5), p. 491-499, → open.
• Bär S, Lange T, Leibfritz D, Hennig J, v. Elverfeldt D, Hövener J-B: “On the Spin Order Transfer from Parahydrogen to Another Nucelus”, Journal of Magnetic Resonance, 2012, 225, p. 25-35, → open access.
• Hövener J-B, Zwick S, Leupold J, Eisenbeiß AK, Scheifele C, Schellenberger F, Hennig J, v.Elverfeldt D, Ludwig U: “Dental MRI: imaging of soft and solid components without ionizing radiation”, Journal of Magnetic Resonance Imaging, 2012, 36(4), p. 841-846, → open access.

2010

• Perman W, Bhattacharya P, Leupold J, Lin A., Harris K, Norton V, Hovener JB, Ross BD: “Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C-labeled compounds using multiple echo 3D bSSFP”, Magnetic Resonance Imaging, 2010, 28 (4), p. 459 - 465 → open access.

2009

• Hövener J-B, Chekmenev E, Harris K, Perman W, Robertson L.W, Ross B.D and Bhattacharya P: “PASADENA Hyperpolarization of ¹³C Biomolecules: Equipment Design and Installation”, Magnetic Resonance Materials in Physics, Biology and Medicine 22 (2): 111 – 121, 2009.→ open access.
• Hövener J-B, Chekmenev E, Harris K, Perman W, Tran T, Ross B.D and Bhattacharya P: “Quality Assurance of PASADENA Hyperpolarization for ¹³C Biomolecules”. Magnetic Resonance Materials in Physics, Biology and Medicine 22 (2): 123 – 134, 2009. → open access

2008 and before

• Hövener J-B, Rigotti D, Amann M, Liu S, Babb J.S, Bachert P, Grossman R.I and Gonen O: “Whole-Brain N acetylaspartate MR Spectroscopic Quantification - Performance Comparison of Metabolite Versus Lipid Nulling”, American Journal of Neuroradiology 29: 1441-1445, 2008.
• Chekmenev E, Hövener J-B, Norton V.A, Harris K, Batchelder L.S, Bhattacharya P, Ross B.D and Weitekamp D.P: “PASADENA Hyperpolarization of Succinic Acid for MRI and NMR spectroscopy”. Journal of the American Chemical Society 130: 4212 – 4213, 2008. → open access.
• Xu V, Chan H, Lin A, Sailasuta N, Valencerina S, Tran T, Hovener, J, Ross B.D: MR Spectroscopy in Diagnosis and Neurological Decision-Making. Seminars in Neurology 28 (4), 2008.
• Hövener J-B, Bachert P: “Experimental approach to determine non-invasively the total content of N-acetyl-L-aspartate (NAA) in the human brain”. Traditional poster for the Int. Conference of Medical Physics 2005, Nürnberg, Germany, and published in Biomedizinische Technik, 2005: 50 (suppl. vol. 1, part 1): 1178 – 1179.

Conference Abstracts (selected)

• Schwaderlapp N, Lickert T, Baer S, Hennig J, Elverfeldt D v. and Hövener J-B. "Earth field MRI Using Continuous SABRE Hyperpolarization" In: Proceedings of the Annual Meeting of the International Society of Magnetic Resonance in Medicine, Salt Lake City, USA, 2013.  
• Hövener, J-B, Schwaderlapp N, Lickert T, Leibfritz D, Borowiak R, Duckett SB, Hennig J, Elverfeldt D v. "A Hyperpolarized Equilibrium". In: Proceedings of the Experimental NMR Conference, Asilomar, USA, 2013.
• Hövener J-B, et al.: “How about pH2 in solution? Continuous hyperpolarization using SABRE”. Gordon Research Coference 2012, Waterville, Maine, USA.
• Hövener J-B, Chekmenev E, et al.: “Quality assurance of PASADENA hyperpolarization for ¹³C Biomolecules”. Experimental NMR Conference (ENC) 2008, Asilomar, USA.
• Hövener, Jan-Bernd: "Strategies to prolong T1 in hyperpolarized ¹⁵N and ¹³C nuclei”. Proceedings of the 16th Scientific Meeting ISMRM 2008, Toronto, Canada.
• Hövener J-B,Chekmenev E, et al.: “Reproducibility and quality assurance in hyperpolarized ¹³C MRI and MRS”. Proceedings of the 15th Scientific Meeting ISMRM 2007, Berlin, Germany.
•  Hövener J-B, Lin A, et al.: “Neurospectroscopy will miss the boat – AGAIN: The unmet need for universal standards and a database”. Proceedings of the 15th Scientific Meeting ISMRM 2007, Berlin, Germany.
• Hövener J-B, Bachert P: “Experimental approach to determine non-invasively the total content of N-acetyl-L-aspartate (NAA) in the human brain”. Int. Conference of Medical Physics 2005, Nürnberg, Germany, and published in Biomedizinische Technik, 2005: 50 (suppl. vol. 1, part 1): 1178 – 1179.

PhD Thesis

¹³C spin hyperpolarization by PASADENA: Instrumentation, preparation of magnetic tracers, and NMR spectroscopy and imaging in vivo.

Diploma Thesis

Development of a technique to determine noninvasively the total content of N-Acetyl-L-Aspartat in the human brain in vivo.