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Department of Radiology - Medical Physics

Dr. Pierre LeVan

Medical Physics
Department of Radiology
University Medical Center Freiburg

Breisacher Straße 60a
79106 Freiburg

Tel.: +49 761 270 93730
Fax: +49 761 270 38310


  • LeVan P, Akin B, Hennig J. Fast imaging for mapping dynamic networks. Neuroimage (in press)
  • Janz P*, Schwaderlapp N*, Heining K*, Häussler U, Korvink JG, von Elverfeldt D, Hennig J, Egert U, LeVan P*, Haas CA*. Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy. Elife 6:e25742.
  • Zaitsev M, Akin B, LeVan P, Knowles BR. Prospective motion correction in functional MRI. Neuroimage 154:33-42.
  • Akin B, Lee HL, Hennig J, LeVan P. Enhanced subject-specific resting-state network detection and extraction with fast fMRI. Hum Brain Mapp 38(2):817-30.


  • LeVan P, Zhang S, Knowles B, Zaitsev M, Hennig J. EEG-fMRI Gradient Artifact Correction by Multiple Motion-Related Templates. IEEE Trans Biomed Eng 63(12):2647-53.
  • Körbl K, Jacobs J, Herbst M, Zaitsev M, Schulze-Bonhage A, Hennig J, LeVan P. Marker-based ballistocardiographic artifact correction improves spike identification in EEG-fMRI of focal epilepsy patients. Clin Neurophysiol. 2016; 127(8):2802-11.
  • Kiviniemi V, Wang X, Korhonen V, Keinänen T, Tuovinen T, Autio J, LeVan P, Keilholz S, Zang YF, Hennig J, Nedergaard M. Ultrafast MR encephalography of physiological brain activity - glymphatic pulsation mechanisms? J Cereb Blood Flow Metab 2016; 36(6):1033-45.
  • Jacobs J, Vogt C, LeVan P, Zelmann R, Gotman J, Kobayashi K. The identification of distinct high-frequency oscillations during spikes delineates the seizure onset zone better than high-frequency spectral power changes. Clin Neurophysiol. 2016; 127(1):129-42.


  • Jäger V, Dümpelmann M, LeVan P, Ramantani G, Mader I, Schulze-Bonhage A, Jacobs J. Concordance of epileptic networks associated with epileptic spikes measured by high-density EEG and fast fMRI. PLoS One 2015; 10(10):e0140537.


  • Jacobs J, Menzel A, Ramantani G, Körbl K, Assländer J, Schulze-Bonhage A, Hennig J, LeVan P. Negative BOLD in default-mode structures measured with EEG-MREG is larger in temporal than extra-temporal epileptic spikes. Front Neurosci. 2014; 8:335.
  • Korhonen V, Hiltunen T, Myllylä T, Wang X, Kantola J, Nikkinen J, Zang YF, LeVan P, Kiviniemi V. Synchronous multiscale neuroimaging environment for critically sampled physiological analysis of brain function: hepta-scan concept. Brain Connect. 2014; 4(9):677-89.
  • Kerber K, Dümpelmann M, Schelter B, LeVan P, Korinthenberg R, Schulze-Bonhage A, Jacobs J. Differentiation of specific ripple patterns helps to identify epileptogenic areas for surgical procedures. Clin Neurophysiol. 2014; 125(7):1339-45.
  • Proulx S, Safi-Harb M, LeVan P, An D, Watanabe S, Gotman J. Increased sensitivity of fast BOLD fMRI with a subject-specific hemodynamic response function and application to epilepsy. Neuroimage 2014;93:59-73
  • Jacobs J, Stich J, Zahneisen B, Assländer J, Ramantani G, Schulze-Bonhage A, Korinthenberg R, Hennig J, LeVan P. Fast fMRI provides high statistical power in the analysis of epileptic networks. Neuroimage 2014;88:282-94
  • Zahneisen B, Assländer J, LeVan P, Hugger T, Reisert M, Ernst T, Hennig J. Quantification and Correction of Respiration Induced Dynamic Field Map Changes in fMRI using 3D single shot techniques. Magn Reson Med 2014;71(3):1093-102


  • Kerber K, LeVan P, Dümpelmann M, Fauser S, Korinthenberg R, Schulze-Bonhage A, Jacobs J. High frequency oscillations mirror disease activity in patients with focal cortical dysplasia. Epilepsia. 2013 Aug;54(8):1428-36
  • LeVan P, Maclaren J, Herbst M, Sostheim R, Zaitsev M, Hennig J. Ballistocardiographic artifact removal from simultaneous EEG-fMRI using an optical motion-tracking system. Neuroimage 2013;75:1-11
  • Assländer J, Zahneisen B, Hugger T, Reisert M, Lee HL, LeVan P, Hennig J. Single shot whole brain imaging using spherical stack of spirals trajectories. Neuroimage 2013;73:59-70
  • Lee HL, Zahneisen B, Hugger T, LeVan P, Hennig J. Tracking dynamic resting-state networks at higher frequencies using MR-encephalography. Neuroimage 2013;65:216-22


  • Zahneisen B, Hugger T, Lee KJ, LeVan P, Reisert M, Lee HL, Assländer J, Zaitsev M, Hennig J. Single shot concentric shells trajectories for ultra fast fMRI. Magn Reson Med. 2012;68(2):484-94


  • Hugger T, Zahneisen B, LeVan P, Lee KJ, Lee HL, Zaitsev M, Hennig J. Fast undersampled functional magnetic resonance imaging using nonlinear regularized parallel image reconstruction. PLoS One. 2011;6(12):e28822
  • Pittau F, LeVan P, Moeller F, Gholipour T, Haegelen C, Zelmann R, Dubeau F, Gotman J. Changes preceding interictal epileptic EEG abnormalities: comparison between EEG/fMRI and intracerebral EEG. Epilepsia. 2011;52(6):1120-9
  • Moeller F, LeVan P, Gotman J. Independent Component Analysis (ICA) of generalized spike wave discharges in fMRI: Comparison with general linear model-based EEG-fMRI. Hum Brain Mapp. 2011;32(2):209-17

2010 and earlier

  • Moeller F, LeVan P, Muhle H, Stephani U, Dubeau F, Siniatchkin M, Gotman J. Absence seizures: individual patterns revealed by EEG-fMRI. Epilepsia. 2010;51(10):2000-10
  • Rathakrishnan R, Moeller F, LeVan P, Dubeau F, Gotman J. BOLD signal changes preceding negative responses in EEG-fMRI in patients with focal epilepsy. Epilepsia. 2010;51(9):1837-45
  • LeVan P, Tyvaert L, Gotman J. Modulation by EEG features of BOLD responses to interictal epileptiform discharges. Neuroimage. 2010;50(1):15-26
  • LeVan P, Tyvaert L, Moeller F, Gotman J. Independent component analysis reveals dynamic ictal BOLD responses in EEG-fMRI data from focal epilepsy patients. Neuroimage. 2010;49(1):366-78
  • Tyvaert L, Chassagnon C, Sadikot AF, LeVan P, Dubeau F, Gotman J. Thalamic nuclei activity in idiopathic generalized epilepsy: an EEG-fMRI study. Neurology. 2009;73(23):2018-22.
  • Moeller F, Tyvaert L, Nguyen DK, LeVan P, Bouthillier A, Kobayashi E, Tampieri D, Dubeau F, Gotman J. EEG-fMRI: adding to standard evaluations of patients with nonlesional frontal lobe epilepsy. Neurology. 2009;73(23):2023-30.
  • Tyvaert L, LeVan P, Dubeau F, Gotman J. Non-invasive dynamic imaging of seizures in epileptic patients. Hum Brain Mapp. 2009;30(12):3993-4011.
  • Yu JM, Tyvaert L, LeVan P, Zelmann R, Dubeau F, Gotman J, Kobayashi E. EEG spectral changes underlying BOLD responses contralateral to spikes in patients with focal epilepsy. Epilepsia. 2009;50(7):1804-1809
  • LeVan P, Gotman J. Independent component analysis as a model-free approach for the detection of BOLD changes related to epileptic spikes: a simulation study. Hum Brain Mapp. 2009;30(7):2021-2031
  • Jacobs J, LeVan P, Moeller F, Boor R, Stephani U, Gotman J, Siniatchkin M. Hemodynamic changes preceding the interictal EEG spikes in patients with focal epilepsy investigated using simultaneous EEG-fMRI. Neuroimage. 2009;45(4):1220-31
  • Jacobs J, LeVan P, Châtillon CE, Olivier A, Dubeau F, Gotman J. High frequency oscillations in intracranial EEGs mark epileptogenicity rather than lesion type. Brain. 2009;132(Pt 4):1022-37
  • Bagshaw AP, Jacobs J, LeVan P, Dubeau F, Gotman J. Effect of sleep stage on interictal high-frequency oscillations recorded from depth macroelectrodes in patients with focal epilepsy. Epilepsia. 2009;50(4):617-28
  • Jacobs J, LeVan P, Olivier A, Andermann F, Dubeau F. Late onset epilepsy in a surgically-treated Sturge-Weber patient. Epileptic Disord. 2008;10(4):312-8
  • Tyvaert L, LeVan P, Grova C, Dubeau F, Gotman J. Effects of fluctuating physiological rhythms during prolonged EEG-fMRI studies. Clin Neurophysiol. 2008;119(12):2762-74
  • Jacobs J, LeVan P, Chander R, Hall J, Dubeau F, Gotman J. Interictal high-frequency oscillations (80-500 Hz) are an indicator of seizure onset areas independent of spikes in the human epileptic brain. Epilepsia. 2008;49(11):1893-907
  • Tyvaert L, Hawco C, Kobayashi E, LeVan P, Dubeau F, Gotman J. Different structures involved during ictal and interictal epileptic activity in malformations of cortical development: an EEG-fMRI study. Brain. 2008;131(Pt 8):2042-60
  • Jacobs J, Rohr A, Moeller F, Boor R, Kobayashi E, LeVan P, Stephani U, Gotman J, Siniatchkin M. Evaluation of epileptogenic networks in children with tuberous sclerosis complex using EEG-fMRI. Epilepsia. 2008;49(5):816-25
  • Jacobs J, Hawco C, Kobayashi E, Boor R, LeVan P, Stephani U, Siniatchkin M, Gotman J. Variability of the hemodynamic response as a function of age and frequency of epileptic discharge in children with epilepsy. Neuroimage. 2008;40(2):601-14
  • Iriarte J, Urrestarazu E, Artieda J, Valencia M, LeVan P, Viteri C, Alegre M. Independent Component Analysis in the Study of Focal Seizures. J Clin Neurophysiol. 2006;23(6):551-8
  • Jirsch JD, Urrestarazu E, LeVan P, Olivier A, Dubeau F, Gotman J. High frequency oscillations during human focal seizures. Brain 2006;129(Pt 6):1593-608
  • Urrestarazu E, Jirsch JD, LeVan P, Hall J, Avoli M, Dubeau F, Gotman J. High frequency intracerebral EEG activity (100-500Hz) following interictal spikes. Epilepsia 2006;47(9):1465-76
  • Urrestarazu E, LeVan P, Gotman J. Independent component analysis identifies ictal bitemporal activity in intracranial recordings at the time of unilateral discharges. Clin Neurophysiol 2006;117(3):549-61
  • LeVan P, Urrestarazu E, Gotman J. A system for automatic artifact removal in ictal scalp EEG based on independent component analysis and Bayesian classification. Clin Neurophysiol 2006;117(4):912-27 
Prof. Dr. Dr. h.c. Jürgen Hennig

Scientific Director
Tel. +49 761 270-38360
Fax +49 761 270-38310

University Medical Center Freiburg
Dept. of Radiology · Medical Physics
Breisacher Straße 60a       
79106 Freiburg, Germany

Laurence Haller
Assistant to the Scientific Director
Tel. +49 761 270-38350

For general inquiries: