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Klinik für Pädiatrische Hämatologie und Onkologie

Publikationen

Originalartikel (Auswahl)

  1. Kollek M, Voigt G, Molnar C, Murad F, Bertele D, Krombholz CF, Bohler S, Labi V, Schiller S, Kunze M, Geley S, Niemeyer CM, Garcia-Saez AJ, Erlacher M. Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation. J Exp Med, 2017, accepted

  1. Buonocore F, Kühnen P, Suntharalingham JP, Del Valle I, Digweed M, Stachelscheid H, Khajavi N, Didi M, Brady AF, Blankenstein O, Procter AM, Dimitri P, Wales JKH, Ghirri P, Knöbl D, Strahm B, Erlacher M, Wlodarski MW, Chen W, Kokai GK, Anderson G, Morrogh D, Moulding DA, McKee SA, Niemeyer CM, Grüters A, Achermann JC. Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans. J Clin Invest. 2017 May 1;127(5):1700-1713.

  1. Ripperger T, Bielack SS, Borkhardt A, Brecht IB, Burkhardt B, Calaminus G, Debatin KM, Deubzer H, Dirksen U, Eckert C, Eggert A, Erlacher M, Fleischhack G, Frühwald MC, Gnekow A, Gohring G, Graf N, Hanenberg H, Hauer J, Hero B, Hettmer S, von Hoff K, Horstmann M, Hoyer J, Illig T, Kaatsch P, Kappler K, Kerl K, Klingebiel T, Kontny U, Kordes U, Körholz D, Koscielniak E, Kramm CM, Kuhlen M, Kulozik AE, Lamottke B, Leuschner I, Lohmann DR, Meinhardt A, Metzler M, Meyer LH, Moser O, Nathrath M, Niemeyer CM, Nustede R, Pajtler KW, Paret C, Rasche M, Reinhardt D, Rieß O, Russo A, Rutkowski S, Schlegelberger B, Schneider D, Schneppenheim R, Schrappe M, Schroeder C, von Schweinitz D, Simon T, Sparber-Sauer M, Spix C, Stanulla M, Steinemann D, Strahm B, Temming P, Thomay K, von Bueren AO, Vorwerk P, Witt O, Wldarski M, Wössmann W, Zenker M, Zimmermann S, Pfister SM, Kratz CP. Childhood Cancer Predisposition Syndromes – a Concise Review and Recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology. Am J Med Genet A. 2017 Apr;173(4):1017-1037.

  1. Krombholz CF, Aumann K, Kollek M, Bertele D, Fluhr S, Kunze M, Niemeyer CM, Flotho C*, Erlacher M*. Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-gammac-/- mice. Haematologica 2016;101:597-606. * shared last authorship

  1. Erlacher M, Grünert SC, Cseh A, Steinfeld R, Salzer U, Lausch E, Nosswitz U, Dückers G, Niehues T, Ehl S, Niemeyer CM, Speckmann C.Reversible pancytopenia and immunodeficiency in a patient with hereditary folate malabsorption. Pediatr Blood Cancer. 2015 Jun;62(6):1091-4.

  1. Labi V, Woess C, Tuzlak S, Erlacher M, Bouillet P, Strasser A, Tzankov A, Villunger A. Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf, Blood. 2014 Apr 24;123(17):2652-62.

  1. Carnevalli LS, Scognamiglio R, Cabezas-Wallscheid N, Rahmig S, Masuda K, Laurenti E, Jöckel L, Kuck A, Sujer S, Erlacher M, Pasparakis M, Ley T, Essers M, Trumpp A. Mice lacking Granzyme B show improved HSC reconstitution and protection from chemotherapy and inflammatory stress, J Exp Med. 2014 May 5;211(5):769-79.

  1. Labi V*, Bertele D*, Woess C, Tischner D, Bock FJ, Schwemmers S, Pahl HL, Geley S, Kunze M, Niemeyer CM, Villunger AV and Erlacher M. Haematopoietic Stem Cell Survival and Transplantation Efficacy is Limited by the BH3-only Proteins Bim and Bmf. EMBO Mol. Med. 2013 Jan;5(1):122-36. (* equal contribution)

  1. Labi V, Erlacher M, Krumschnabel G, Manzl C, Tzankov A, Pinon J, Egle A, Villunger A. Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation. Genes Dev. 2010 Aug 1;24(15):1602-7.

  1. Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Sakamoto KM, Gorr TA, Mehta P, Schmid I, Kropshofer G, Corbacioglu S, Lang PJ, Klein C, Schlegel PG, Heinzmann A, Schneider M, Starý J, van den Heuvel-Eibrink MM, Hasle H, Locatelli F, Sakai D, Archambeault S, Chen L, Russell RC, Sybingco SS, Ohh M, Braun BS, Flotho C, Loh ML. Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet. 2010 Aug 8.

  1. Erlacher M, Heiss J, Hainmann I, Uhl M, Budde U, Oldenburg J, Ivaskevicius V, Al-Jamali J, Zajonc H, Superti-Furga A, Zieger B. Novel findings in two patients with late-diagnosed afibrinogenemia: intraosseous hemorrhage and fingertip necrosis. Haemophilia. 2009, Jul;15(4):980-2.

  1. Labi V, Erlacher M, Kiessling S, Manzl S, Frenzel A, O`Reilly LA, Strasser A, Villunger A. Targeted deletion of the BH3-only gene bmf causes defects in B cell homeostasis and accelerates gamma-radiation-induced thymic lymphoma development. J Exp Med. 2008 Mar 17;205(3):641-55.

  1. Erlacher M, Labi V, Böck G, Tzankov A, Strasser A, Villunger A. Combined loss of Bim and Puma mirrors the effects of Bcl-2 overexpression in some but not all forms of cell death. J Exp Med. 2006 Dec 25;203(13):2939-51.

  1. You H, Pellegrini M, Tsuchihara K, Yamamoto K, Hacker G, Erlacher M, Villunger A, Mak TW. FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med. 2006 Jul 10;203(7):1657-63. Epub 2006 Jun 26.

  1. Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L, Adams JM, Strasser A, Villunger A. The BH3-only proteins PUMA/bbc3 and Bim are rate-limiting for γ-radiation and glucocorticoid induced apoptosis of lymphoid cells in vivo. 2005 Aug 23; 2005 Dec 15;106(13):4131-8.

  1. Erlacher M, Knoflach M, Stec IE, Böck G, Wick G, Wiegers GJ. TCR signaling inhibits glucocorticoid-induced apoptosis in murine thymocytes depending on the stage of development. Eur J Immunol. 2005 Nov;35(11):3287-96.

 

Übersichtsarbeiten:

  1. Kollek M, Muller A, Egle A, Erlacher M. Bcl-2 proteins in development, health, and disease of the hematopoietic system. FEBS J 2016;283:2779-2810.

  1. Erlacher M, Strahm B. Missing Cells: Pathophysiology, Diagnosis, and Management of (Pan)Cytopenia in Childhood. Front Pediatr. 2015 Jul 13;3:64. doi: 10.3389/fped.2015.00064. eCollection 2015. Review.

  1. Labi V, Erlacher M. How cell death shapes cancer. Cell Death Dis. 2015 Mar 5;6:e1675. doi: 10.1038/cddis.2015.20. Review.

 

Buchkapitel:

  1. Lauten M, Erlacher M.: Hämatologie. In: Spehr C, Gahr M, Dötsch J (eds.): Pädiatrie (5. Auflage) (Springer, in press)

  1. Erlacher M, Niemeyer CM. Myeloproliferative disorders and neonatal leukemias. Buchbeitrag in Dame et al (Eds): Atlas of the Cellular and Molecular Development of Human Hematopoiesis (Springer, 2014)

  1. Erlacher M, Michalak EM, Strasser A, Villunger A. The BH3-only proteins Puma and Noxa - two brothers in arms. Buchbeitrag in Debatin, Fulda (Eds): Apoptosis and Cancer Therapy (Wiley-VCH, 2006)

Ärztliche Direktorin
Klinik für Pädiatrische Hämatologie und Onkologie

Mathildenstraße 1 (Postadresse)
Heiliggeiststraße 1 (Anfahrt)
79106 Freiburg

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