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Institut für Klinische Pathologie

Arbeitsgruppe Professor Dr. Silke Laßmann

Unsere Arbeitsgruppe „Molekulare Tumorpathologie“ beschäftigt sich mit soliden Tumoren und  hämatologischen Neoplasien sowie deren Vorstufen.

Die enge interdisziplinäre Vernetzung mit Arbeitsgruppen des Comprehensive Cancer Center Freiburg (CCCF) und der Albert-Ludwigs-Universität sowie mit anderen Kliniken und Instituten im In- und Ausland stärkt unser Team.

Kontakt:
Prof. Dr. S. Laßmann
silke.lassmann@uniklinik-freiburg.de
+49 761 270-80620

 

 

 

  • Molekulare Mechanismen der Karzinogenese
  • Molekulare Mechanismen zielgerichteter Therapien und Therapieprädiktion
  • Molekularpathologie und innovative Techniken (z. B. NGS)
  • Epigenetik
  • Genetik, Signaltransduktion
  • Comprehensive Cancer Center Freiburg
  • Institut für Molekulare Medizin und Zellforschung, Freiburg
  • Max-Planck-Institut für Immunbiologie und Epigentik, Freiburg
  • HelmholtzZentrum München; Institut für Pathologie
  • Memorial Sloan Kettering Cancer Center, Dept. of Pathology, New York, USA
  • "(Epi-)Genomics":
    ISH, qPCR, dig. PCR, Pyrosequencing, NGS, ChIP(Seq)
  • "Proteomics":
    WB, IHC, IF, in situ-PLA, Protein Arrays
  • "Cellular":
    FACS, siRNA, Organotypic cultures, life imaging, ErbB-dimer models, TMA, Laser-Microdissection
Silke LaßmannApl.-Prof. Dr.; M.A.
Kathrin SingvogelDr. rer. nat.
Tamara Werner Dr. rer. nat.
Rebecca EberhardtPhD-Student, Dipl. Mol.Med.
Martin LuxPhD-Student, Dipl. Biochem.
Fabian BeierMTA
Nicola HerbenerMTA

Deutsche Forschungsgemeinschaft

  • 2012-2020:
    SFB992 Teilprojekt C3 "Epigenetic regulation of esophageal cancer"
  • 2010-2021:
    SFB850 Teilprojekt Z1 "Validation of Mechanisms involved in invasion and metastasis in human cancer"
  • 2010-2021:
    SFB 850 Teilprojekt C5 "The role of receptor tyrosine kinase signaling for esophageal cancer cell motility and metastasis"
  • 2015-2018:
    Exzellenzcluster BIOSS2 "Modelling epithelial cancers for targeting carcinogenesis and progression"

Deutsches Konsortium für Translationale Krebsforschung (DKTK)

  • 2012-2020: "Program Molecular Diagnostics"

Mushett Family Foundation, Chester, USA:

  • 2004-2017: "Program grant in cancer research"

Link zu Pubmed 


2017:

Geißler AL, Geißler M, Kottmann D, Lutz L, Fritsch R, Weddeling B, Makowiec F, Werner M, Lassmann S. ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer. Oncotarget, 2017 Feb 9. doi: 10.18632/oncotarget.15211. [Epub ahead of print] PubMed PMID: 28199979

Zahaf NI, Lang AE, Kaiser L, Fichter CD, Lassmann S, McCluskey A, Augspach A,  Aktories K, Schmidt G. Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells. Sci Rep. 2017 Jan 27;7:41252.


2016:

Kovaleva V, Geissler AL, Lutz L, Fritsch R, Makowiec F, Wiesemann S, Hopt UT, Passlick B, Werner M, Lassmann S. Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing. Mol Cancer. 2016 Oct 18;15(1):63.

Ahrens TD, Lutz L, Lassmann S, Werner M. Turning Skyscrapers into Town Houses: Insights into Barrett's Esophagus. Pathobiology. 2016 Sep 23. [Epub ahead of print] PubMed PMID: 27656900.

Czulkies BA, Mastroianni J, Lutz L, Lang S, Schwan C, Schmidt G, Lassmann S, Zeiser R, Aktories K, Papatheodorou P. Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells. Oncotarget. 2016 Jul 6. doi: 10.18632/oncotarget.10425.

Lutz L, Coutiño Fitzner I, Ahrens T, Geißler AL, Makowiec F, Hopt UT, Bogatyreva L, Hauschke D, Werner M, Lassmann S. Histone modifiers and marks define heterogeneous groups of colorectal carcinomas and affect responses to HDAC inhibitors in vitro. Am J Cancer Res 2016;6(3):664-676.

Koczorowska MM, Tholen S, Bucher F, Lutz L, Kizhakkedathu JN, De Wever O, Wellner UF, Biniossek ML, Stahl A, Lassmann S, Schilling O. Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations. Mol Oncol. 2016 Jan;10(1):40-58.

Spohn L, Fichter C, Werner M, Lassmann S. Subcellular localization of EGFR in esophageal carcinoma cell lines. J Cell Commun Signal. 2016 Mar;10(1):41-7.

Ahrens TD, Timme S, Ostendorp J, Bogatyreva L, Hoeppner J , Hopt UT, Hauschke D, Werner M, Lassmann S. Response of esophageal cancer cells to epigenetic inhibitors is mediated via altered thioredoxin activity. Lab Invest. 2016 Mar;96(3):307-16.


2015

Weißer J, Lai ZW, Bronsert P, Kuehs M, Drendel V, Timme S, Kuesters S, Jilg CA, Wellner UF, Lassmann S, Werner M, Biniossek ML, Schilling O. Quantitative proteomic analysis of formalin-fixed, paraffin-embedded clear cell renal cell carcinoma tissue using stable isotopic dimethylation of primary amines. BMC Genomics. 2015 Jul 29;16:559.

Ahrens TD, Timme S, Hoeppner J, Ostendorp J, Hembach S, Follo M, Hopt UT, Werner M, Busch H, Boerries M, Lassmann S. Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine. Epigenetics. 2015;10(5):431-45.

Münch C, Dragoi D, Frey AV, Thurig K, Lübbert M, Wäsch R, Bogatyreva L, Hauschke D, Lassmann S, Werner M, May AM. Therapeutic polo-like kinase 1 inhibition results in mitotic arrest and subsequent cell death of blasts in the bone marrow of AML patients and has similar effects in non-neoplastic cell lines. Leuk Res. 2015 Apr;39(4):462-70.

Sijare F, Geißler AL, Fichter CD, Hergeth SP, Bogatyreva L, Hauschke D, Schneider R, Werner M, Lassmann S. Aurora B expression and histone variant H1.4S27 phosphorylation are no longer coordinated during metaphase in aneuploidy colorectal carcinomas. Virchows Arch. 2015 May;466(5):503-15.

Dahl E, Jung A, Fassunke J, Hummel M, Penzel R, Dietmaier W, Laßmann S. [Chances and risks of blood-based molecular pathological analysis of circulating tumor cells (CTC) and cell-free DNA (cfDNA) in personalized cancer therapy: Positional paper from the study group on liquid biopsy of the working group for molecular pathology in the German Society of Pathology (DGP)]. Pathologe. 2015 Feb;36(1):92-7.

Herr R, Köhler M, Andrlová H, Weinberg F, Möller Y, Halbach S, Lutz L, Mastroianni J, Klose M, Bittermann N, Kowar S, Zeiser R, Olayioye MA, Lassmann S, Busch H, Boerries M, Brummer T. B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells. Cancer Res. 2015 Jan 1;75(1):216-29.

Haug S, Schnerch D, Halbach S, Mastroianni J, Dumit VI, Follo M, Hasenburg A, Köhler M, Dierbach H, Herzog S, Proske A, Werner M, Dengjel J, Brummer T, Laßmann S, Wäsch R, Zeiser R. Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer. Int J Cancer. 2015 May 15;136(10):2328-40.


2014

Rylova SN, Barnucz E, Barnucz E, Fani M, Braun F, Werner M, Lassmann S, Maecke HR, Maecke HR, Weber WA. Does Imaging αvβ3 Integrin Expression with PET Detect Changes in Angiogenesis During Bevacizumab Therapy? J Nucl Med. 2014 Nov;55(11):1878-84. (IF=6,160)

Rönsch K, Jägle S, Rose K, Seidl M, Baumgartner F, Freihen V, Yousaf A, Metzger E, Lassmann S, Schüle R, Zeiser R, Michoel T, Hecht A. SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer. Mol Oncol. 2015 Feb;9(2):335-54.

Fichter CD, Gudernatsch V, Przypadlo CM, Follo M, Schmidt G, Werner M, Lassmann S. ErbB targeting inhibitors repress cell migration of esophageal squamous cell carcinoma and adenocarcinoma cells by distinct signaling pathways. J Mol Med (Berl). 2014 Aug 6. [Epub ahead of print] PubMed PMID: 25091467.

Bronsert P, Weißer J, Biniossek ML, Kuehs M, Mayer B, Drendel V, Timme S, Shahinian H, Küsters S, Wellner UF, Lassmann S, Werner M, Schilling O. Impact of  Routinely Employed Procedures for Tissue Processing on the Proteomic Analysis of  Formalin-Fixed Paraffin-Embedded Tissue. Proteomics Clin Appl. 2014 Oct;8(9-10):796-804.

Vogel T, Lassmann S. Epigenetics: development, dynamics and disease. Cell Tissue Res. 2014Jun;356(3):451-5

Ahrens T, Werner M, Lassmann S. Epigenetics in Esophageal Cancers, Cell Tissue Res. 2014 Jun;356(3):643-55.

Jägle S, Rönsch K, Timme S, Andrlová H, Bertrand M, Jäger M, Proske A, Schrempp M, Yousaf A, Michoel T, Zeiser R, Werner M, Lassmann S, Hecht A. Silencing of the EPHB3 tumor-suppressor gene in human colorectal cancer through decommissioning of a transcriptional enhancer. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4886-91

Fichter CD, Timme S, Braun JA, Gudernatsch V, Schöpflin A, Bogatyreva L, Geddert H, Faller G, Klimstra D, Tang L, Hauschke D, Werner M, Lassmann S. EGFR, HER2 and HER3 dimerization patterns guide targeted inhibition in two histotypes of esophageal cancer. Int J Cancer. 2014 Oct 1;135(7):1517-30.

May AM, Frey AV, Bogatyreva L, Benkisser-Petersen M, Hauschke D, Lübbert M, Wäsch R, Werner M, Hasskarl J, Lassmann S. ID2 and ID3 protein expression mirrors granulopoietic maturation and discriminates between acute leukemia subtypes. Histochem Cell Biol. 2014 Apr;141(4):431-40. 

Lassmann S, Werner M. Are Caudal-Type Homeobox Genes Causal for Gastro-Esophageal Reflux Disease and Barrett's Esophagus? Dig Dis Sci. 2014 Jan;59(1):16-8. 

Timme S, Ihde S, Fichter CD, Waehle V, Bogatyreva L, Atanasov K, Kohler I, Schöpflin A, Geddert H, Faller G, Klimstra D, Tang L, Reinheckel T, Hauschke D, Busch H, Boerries M, Werner M, Lassmann S. STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas. Oncogene. 2014 Jun 19;33(25):3256-66.  

Wöhrle FU, Halbach S, Aumann K, Schwemmers S, Braun S, Auberger P, Schramek D, Penninger JM, Laßmann S, Werner M, Waller CF, Pahl HL, Zeiser R, Daly RJ, Brummer T. Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors. Leukemia. 2013 Jan;27(1):118-29

Lassmann S, Werner M. Predictive pathology in routine diagnostics of solid tumors. Histol Histopathol. 2012 Mar;27(3):289-96.

Heinke J, Kerber M, Rahner S, Mnich L, Lassmann S, Helbing T, Werner M, Patterson C, Bode C, Moser M. Bone morphogenetic protein modulator BMPER is highly expressed in malignant tumors and controls invasive cell behaviour. Oncogene. 2012 Jun 14;31(24):2919-30. 

Beussel S, Hasenburg A, Bogatyreva L, Hauschke D, Werner M, Lassmann S. Aurora-B protein expression is linked to initial response to taxane-based first-line chemotherapy in stage III ovarian carcinoma. J Clin Pathol 2012 Jan;65(1):29-35.

Herz C, Schlürmann F, Batarello D, Fichter CD, Schöpflin A, Münch C, Hauschke D, Werner M, Lassmann S. Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition. Molecular Carcinogenesis 2012 Sep;51(9):696-710. 


2013

May AM, Frey AV, Bogatyreva L, Benkisser-Petersen M, Hauschke D, Lübbert M, Wäsch R, Werner M, Hasskarl J, Lassmann S. ID2 and ID3 protein expression mirrors granulopoietic maturation and discriminates between acute leukemia subtypes. Histochem Cell Biol. 2013 Nov 30. [Epub ahead of print] PubMed PMID: 24292846. (IF=2.613)

Timme S, Ihde S, Fichter CD, Waehle V, Bogatyreva L, Atanasov K, Kohler I, Schöpflin A, Geddert H, Faller G, Klimstra D, Tang L, Reinheckel T, Hauschke D, Busch H, Boerries M, Werner M, Lassmann S. STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas. Oncogene. 2013 Aug 5. doi: 10.1038/onc.2013.298. [Epub ahead of print] (IF=7.357)

Wöhrle FU, Halbach S, Aumann K, Schwemmers S, Braun S, Auberger P, Schramek D, Penninger JM, Laßmann S, Werner M, Waller CF, Pahl HL, Zeiser R, Daly RJ, Brummer T. Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors. Leukemia. 2013 Jan;27(1):118-29 (IF=9.561)


2012

Lassmann S, Werner M. Predictive pathology in routine diagnostics of solid tumors. Histol Histopathol. 2012 Mar;27(3):289-96. (IF=2.502)

Heinke J, Kerber M, Rahner S, Mnich L, Lassmann S, Helbing T, Werner M, Patterson C, Bode C, Moser M. Bone morphogenetic protein modulator BMPER is highly expressed in malignant tumors and controls invasive cell behaviour. Oncogene. 2012 Jun 14;31(24):2919-30.  (IF=7.414)

Beussel S, Hasenburg A, Bogatyreva L, Hauschke D, Werner M, Lassmann S. Aurora-B protein expression is linked to initial response to taxane-based first-line chemotherapy in stage III ovarian carcinoma. J Clin Pathol 2012 Jan;65(1):29-35. (IF=2.475)

Herz C, Schlürmann F, Batarello D, Fichter CD, Schöpflin A, Münch C, Hauschke D, Werner M, Lassmann S. Occurrence of Aurora A positive multipolar mitoses in distinct molecular classes of colorectal carcinomas and effect of Aurora A inhibition. Molecular Carcinogenesis 2012 Sep;51(9):696-710.  (IF=3.202)


2011

Rönsch K, Jäger M, Schöpflin A, Danciu M, Laßmann S, Hecht A. Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer. Epigenetics. 2011 May 1;6(5):610-622. (IF= 4.584) 

Fichter DC, Herz C, Muench C, Opitz OG, Werner M, Lassmann S. Occurrence of multipolar mitoses and association with Aurora-A/-B kinases and p53 mutations in aneuploid esophageal carcinoma cells. BMC Cell Biol. 2011 Apr 6;12:13. (IF= 2.654)

Aumann K, Lassmann S, Schöpflin A, May AM, Wöhrle FU, Zeiser R, Waller CF, Hauschke D, Werner M, Brummer T. The immunohistochemical staining pattern of Gab2 correlates with distinct stages of chronic myeloid leukemia. Hum Pathol. 2011 Feb 1. [Epub ahead of print]  

Münch C, May AM, Hauschke D, Roth J, Lassmann S, Werner M. Internuclear chromosome distribution of dysplastic megakaryocytes in myelodysplastic syndromes is dependent on the level of ploidy.  Chromosoma. 2011 Feb 1. [Epub ahead of print]


2010

Schlachter M, Reisert M, Herz C, Schluermann F, Lassmann S, Werner M, Burkhardt H, Ronneberger O. Harmonic Filters for 3 D Multi-Channel Data: Rotation Invariant Detection of Mitoses in Colorectal Cancer. IEEE Trans Med Imaging. 2010 Jun 7. [Epub ahead of print]

Kayser G, Kassem A, Sienel W, Schulte-Uentrop L, Mattern D, Aumann, K, Stickeler E, Werner M, Passlick B, zur Hausen A. Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1. Diagn Pathol. 2010 Apr 12;5:22

Neumann J, Feuerhake F, Kayser G, Wiech T, Aumann K, Passlick B, Fisch P, Werner M, zur Hausen A. Gene expression profiles of lung adenocarcinoma linked to histopathological grading and survival but not to EGF-R status: a microarray study. BMC Cancer. 2010 Mar 2;10:77

Manthey C, Mern DS, Gutmann A, Zielinski AJ, Herz C, Lassmann S, Hasskarl J. Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cells. BMC Cell Biol. 2010 Jan 14;11:2


2009

Stumpf M, Hasenburg A, Riener MO, Jütting U, Wang C, Shen Y, Orlowska-Volk M, Fisch P, Wang Z, Gitsch G, Werner M, Lassmann S. Intraepithelial CD8-positive T lymphocytes predict survival for patients with serous stage III ovarian carcinomas: relevance of clonal selection of T lymphocytes. Br J Cancer. 2009 Nov 3;101(9):1513-21.

Lassmann S, Danciu M, Müller M, Weis R, Makowiec F, Schulte-Mönting J, Hopt UT, Werner M. Aurora A is differentially expressed and regulated in chromosomal and microsatellite instable sporadic colorectal cancers. Mod Pathol. 2009 Oct;22(10):1385-97.

Wiech T, Stein S, Lachenmaier V, Schmitt E, Schwarz-Finsterle J, Wiech E, Hildenbrand G, Werner M, Hausmann M. Spatial allelic imbalance of BCL2 genes and chromosome 18 territories in nonneoplastic and neoplastic cervical squamous epithelium. Eur Biophys J. 2009 Jul;38(6):793-806.

Markert S, Lassmann S, Gabriel B, Klar M, Werner M, Gitsch G, Kratz F, Hasenburg A. Alpha-folate receptor expression in epithelial ovarian carcinoma and non-neoplastic ovarian tissue. Anticancer Res. 2008 Nov-Dec;28(6A):3567-72.

Harder J, Engelstaedter V, Usadel H, Lassmann S, Werner M, Baier P, Otto F, Varbanova M, Schaeffner E, Olschewski M, Blum HE, Opitz OG. CpG-island methylation of the ER promoter in colorectal cancer: analysis of micrometastases in lymph nodes from UICC stage I and II patients. Br J Cancer. 2009 Jan 27;100(2):360-5.

Lassmann S, Kreutz C, Schoepflin A, Hopt U, Timmer J, Werner M. A novel approach for reliable microarray analysis of microdissected tumor cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens. J Mol Med. 2009 Feb;87(2):211-24.


2008

Lassmann S, Kreutz C, Schoepflin A, Hopt U, Timmer J, Werner M. A novel approach for reliable microarray analysis of microdissected tumor cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens. J Mol Med. 2008 Dec 6. [Epub ahead of print]

Wellner U, Mattern D, Keck T. Clinical Challenges and Images in GI. Gastroenterology. 2008 Nov 12

Wiech T, Nikolopoulos E, Hausmann M, Walch A, Werner M, Fisch P.A Case of Heterogeneous Breast Cancer with Clonally Expanded T-Cells in the HER2+ and Metastasis of the HER2- Tumor Cells. Breast J. 2008 Sep-Oct;14(5):487-91.

Bauer VL, Braselmann H, Henke M, Mattern D, Walch A, Unger K, Baudis M, Lassmann S, Huber R, Wienberg J, Werner M, Zitzelsberger HF. Chromosomal changes characterize head and neck cancer with poor prognosis. J Mol Med. 2008 Sep 23.

Brücher BL, Keller G, Werner M, Müller U, Lassmann S, Cabras AD, Fend F, Busch R, Stein H, Allescher HD, Molls M, Siewert JR, Höfler H, Specht K. Using Q-RT-PCR to measure cyclin D1, TS, TP, DPD, and Her-2/neu as predictors for response, survival, and recurrence in patients with esophageal squamous cell carcinoma following radiochemotherapy. Int J Colorectal Dis. 2009 Jan;24(1):69-77

Wiech T, Nikolopoulos E, Weis R, Langer R, Bartholomé K, Timmer J, Walch AK, Höfler H, Werner M. Genome-wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arrays. Lab Invest. 2008 Jul 28. [Epub ahead of print]

Riener MO, Nikolopoulos E, Herr A, Wild PJ, Hausmann M, Wiech T, Orlowska-Volk M, Lassmann S, Walch A, Werner M. Microarray comparative genomic hybridization analysis of tubular breast carcinoma shows recurrent loss of the CDH13 locus on 16q. Hum Pathol. 2008 Jul 23. [Epub ahead of print] 

Kassem A, Schöpflin A, Diaz C, Weyers W, Stickeler E, Werner M, Zur Hausen A.Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res. 2008 Jul 1;68(13):5009-13. 

Wiech T, Nikolopoulos E, Lassman S, Heidt T, Schöpflin A, Sarbia M, Werner M, Shimizu Y, Sakka E, Ooka T, zur Hausen A. Cyclin D1 expression is induced by viral BARF1 and is overexpressed in EBV-associated gastric cancer. Virchows Arch. 2008 Jun;452(6):621-7.

Lassmann S, Opitz OG. The new look of colorectal cancer stem cells. Gastroenterology. 2008 Apr;134(4):1262-4.

Arndt S, Wiech T, Mader I, Aschendorff A, Maier W. Rare extracranial localization of primary intracranial neoplasm. Diagn Pathol. 2008 Apr 16;3:14.

Wittel UA, Wiech T, Chakraborty S, Boss B, Lauch R, Batra SK, Hopt UT. Taurocholate-induced pancreatitis: a model of severe necrotizing pancreatitis in mice. Pancreas. 2008 Mar;36(2):e9-21.


2007

Lassmann S, Shen Y, Jütting U, Whiele P, Walch A, Gitsch G, Hasenburg A, Werner M. [Aurora-a is a predictive marker for stage III epithelial ovarian cancers] Verh Dtsch Ges Pathol. 2007;91:225-32.

Lassmann S, Tang L, Capanu M, Brabletz T, Schöpflin A, Zur Hausen A, Gonen M, Kemeny N, Shia J, Klimstra D, Werner M. Predictive molecular markers for colorectal cancer patients with resected liver metastasis and adjuvant chemotherapy. Gastroenterology. 2007 Dec;133(6):1831-9

Arndt S, Wiech T, Mader I, Maier W. Entire infrasellar craniopharyngioma simulating clival chordoma. Otolaryngol Head Neck Surg. 2007 Dec;137(6):981-3.

Neumann HP, Vortmeyer A, Schmidt D, Werner M, Erlic Z, Cascon A, Bausch B, Januszewicz A, Eng C. Evidence of MEN-2 in the original description of classic pheochromocytoma. N Engl J Med. 2007 Sep 27;357(13):1311-5

Göbel H, Gloy J, Neumann J, Wiech T, Pisarski P, Böhm J. Donor-derived small cell lung carcinoma in a transplanted kidney. Transplantation. 2007 Sep 27;84(6):800-2.

Wiese AH, Auer J, Lassmann S, Nährig J, Rosenberg R, Höfler H, Rüger R, Werner M. Identification of gene signatures for invasive colorectal tumor cells. Cancer Detect Prev. 2007;31(4):282-95

Rauser S, Weis R, Braselmann H, Feith M, Stein HJ, Langer R, Hutzler P, Hausmann M, Lassmann S, Siewert JR, Höfler H, Werner M, Walch A. Significance of HER2 low-level copy gain in Barrett's cancer: implications for fluorescence in situ hybridization testing in tissues. Clin Cancer Res. 2007 Sep 1;13(17):5115-23

Rischke HC, Momm F, Henke M, Wiech T, Frommhold H. Does radiation prevent 5-fluorouracil-induced colitis in the early phase of radiochemotherapy? A case report and literature review. Strahlenther Onkol. 2007 Aug;183(8):459-63.

Thomas-Kaskel AK, Mattern D, Köhler G, Finke J, Behringer D. Reticulated platelet counts correlate with treatment response in patients with idiopathic thrombocytopenic purpura and help identify the complex causes of thrombocytopenia in patients after allogeneic hematopoietic stem cell transplantation. Cytometry B Clin Cytom. 2007 Jul;72(4):241-8. 

Lassmann S, Shen Y, Jütting U, Wiehle P, Walch A, Gitsch G, Hasenburg A, Werner M. Predictive value of Aurora-A/STK15 expression for late stage epithelial ovarian cancer patients treated by adjuvant chemotherapy. Clin Cancer Res. 2007 Jul 15;13(14):4083-91

Lassmann S, Schuster I, Walch A, Göbel H, Jütting U, Makowiec F, Hopt U, Werner M. STAT3 mRNA and protein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation. J Clin Pathol. 2007 Feb;60(2):173-9

Lassmann S, Weis R, Makowiec F, Roth J, Danciu M, Hopt U, Werner M. Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas. J Mol Med. 2007 Mar;85(3):293-304


2006

Henke M, Mattern D, Pepe M, Bézay C, Weissenberger C, Werner M, Pajonk F. Abstract Do erythropoietin receptors on cancer cells explain unexpected clinical findings? J Clin Oncol. 2006 Oct 10;24(29):4708-13

Reiter R, Gais P, Jütting U, Steuer-Vogt MK, Pickhard A, Bink K, Rauser S, Lassmann S, Höfler H, Werner M, Walch A. Aurora kinase A messenger RNA overexpression is correlated with tumor progression and shortened survival in head and neck squamous cell carcinoma. Clin Cancer Res. 2006 Sep 1;12(17):5136-41

Lassmann S, Werner M. A commentary on the article "Prevalence of the mismatch repair-deficient phenotype in colonic adenomas arising in HNPCC patients--results of a 5-year follow-up study". Int J Colorectal Dis. 2006 Oct;21(7):642-4

Bähr A, Schulte-Vallentin M, Hasse J, Werner M, Jüttner E, Uhl M, Niemeyer C, Kontny U. [Extrathoracal pulmonary sequestration in the differential diagnosis of paravertebral tumors in the neonate] Klin Padiatr. 2006 Jan-Feb;218(1):13-5

Gerlach U, Kayser G, Walch A, Hopt U, Schulte-Mönting J, Werner M, Lassmann S. Centrosome-, chromosomal-passenger- and cell-cycle-associated mRNAs are differentially regulated in the development of sporadic colorectal cancer. J Pathol. 2006 Mar;208(4):462-72

Lassmann S, Hennig M, Rosenberg R, Nährig J, Schreglmann J, Krause F, Poignee-Heger M, Nekarda H, Höfler H, Werner M. Thymidine phosphorylase, dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expression in primary colorectal tumors-correlation to tumor histopathology and clinical follow-up. Int J Colorectal Dis. 2006 Apr;21(3):238-47


2005

Gabriel B, Watermann D, Hancke K, Gitsch G, Werner M, Tempfer C, Hausen A. Increased expression of matrix metalloproteinase 2 in uterosacral ligaments is associated with pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 2006 Sep;17(5):478-82

Kontny U, Boppana S, Jung A, Goebel H, Strahm B, Peters A, Dormann S, Werner M, Bader P, Fisch P, Niemeyer C. Post-transplantation lymphoproliferative disorder of recipient origin in a boy with acute T-cell leukemia with detection of B-cell clonality 3 months before stem cell transplantation. Haematologica. 2005 Nov;90 Suppl:ECR27.

Lassmann S, Gerlach UV, Technau-Ihling K, Werner M, Fisch P. Application of BIOMED-2 primers in fixed and decalcified bone marrow biopsies: analysis of immunoglobulin H receptor rearrangements in B-cell non-Hodgkin's lymphomas. J Mol Diagn. 2005 Nov;7(5):582-91

Friebe V, Keck T, Mattern D, Schmitt-Graeff A, Werner M, Mikami Y, Adam U, Hopt UT. Serous cystadenocarcinoma of the pancreas: management of a rare entity. Pancreas. 2005 Aug;31(2):182-7

Wiech T, Walch A, Werner M. Histopathological classification of nonneoplastic and neoplastic gastrointestinal submucosal lesions. Endoscopy. 2005 Jul;37(7):630-4

Kayser G, Gerlach U, Walch A, Nitschke R, Haxelmans S, Kayser K, Hopt U, Werner M, Lassmann S. Numerical and structural centrosome aberrations are an early and stable event in the adenoma-carcinoma sequence of colorectal carcinomas. Virchows Arch. 2005 Jul;447(1):61-5

Gabriel B, Denschlag D, Göbel H, Fittkow C, Werner M, Gitsch G, Watermann D. Uterosacral ligament in postmenopausal women with or without pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 2005 Nov-Dec;16(6):475-9

Wiech T, Timme S, Riede F, Stein S, Schuricke M, Cremer C, Werner M, Hausmann M, Walch A. Human archival tissues provide a valuable source for the analysis of spatial genome organization. Histochem Cell Biol. 2005 Mar;123(3):229-38

Bredel C, Lassmann S, Pollack IF, Knoth R, Hamilton RL, Volk B, Werner M, Bredel M. DNA topoisomerase IIalpha and Her-2/neu gene dosages in pediatric malignant gliomas. Int J Oncol. 2005 May;26(5):1187-92


2004

Walch A, Specht K, Braselmann H, Stein H, Siewert JR, Hopt U, Höfler H, Werner M. Coamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett's carcinoma. Int J Cancer. 2004 Dec 10;112(5):747-53

Hausmann M, Cremer C, Linares-Cruz G, Nebe TC, Peters K, Plesch A, Tham J, Vetter M, Werner M. Standardisation of FISH-procedures: summary of the Second Discussion Workshop. Cell Oncol. 2004;26(3):119-24

von Dobschuetz E, Walch A, Werner M, Hopt UT, Adam U. Giant ancient schwannoma of pancreatic head treated by extended pancreatoduodenectomy. Pancreatology. 2004;4(6):505-8

Albrecht B, Hausmann M, Zitzelsberger H, Stein H, Siewert JR, Hopt U, Langer R, Höfler H, Werner M, Walch A. Array-based comparative genomic hybridization for the detection of DNA sequence copy number changes in Barrett's adenocarcinoma. J Pathol. 2004 Jul;203(3):780-8

Neeff H, Obermaier R, Technau-Ihling K, Werner M, Kurtz C, Imdahl A, Hopt UT. Solitary fibrous tumour of the liver: case report and review of the literature. Langenbecks Arch Surg. 2004 Aug;389(4):293-8

Lassmann S, Bauer M, Rosenberg R, Nekarda H, Soong R, Rüger R, Höfler H, Werner M. Identification of occult tumor cells in node negative lymph nodes of colorectal cancer patients by cytokeratin 20 gene and protein expression. Int J Colorectal Dis. 2004 Mar;19(2):87-94.

Kawakami N, Lassmann S, Li Z, Odoardi F, Ritter T, Ziemssen T, Klinkert WE, Ellwart JW, Bradl M, Krivacic K, Lassmann H, Ransohoff RM, Volk HD, Wekerle H, Linington C, Flügel A. The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J Exp Med. 2004 Jan 19;199(2):185-97.


2003 und vorher:

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Institut für Klinische Pathologie
Universitätsklinikum Freiburg
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