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Klinik für Plastische und Handchirurgie

Lymphangiogenesis in adipose tissue equivalents

Dr. Sandra Straßburg

The long-term goal of my research is to develop a tissue replacement that corrects deformities in the fatty tissue while at the same time prevents the formation of secondary lymphedema.

After certain types of tumors have been surgically removed, for example in the case of breast cancer, the result is distortion of fatty tissue as well as a lack of lymphatic vessels and lymph nodes. A secondary lymphedema can then develop which places considerable strain on the patient and limits their quality of life. Clinical approaches to correcting malformed fatty tissue and treating secondary lymphedema are currently associated with undesirable side effects, safety risks and low probabilities of success. Therefore, tissue engineering using suitable cells embedded in a biomaterial may represent an ideal strategy to engineer a durable adipose tissue substitute. With the aid of the body's own tissue, cells and stem cells, such as adipose-derived stem cells, endothelial cells and lymphatic endothelial cells, I want to generate an adipose tissue equivalent equipped with a vascular- and a lymphatic capillary network in a biomaterial specifically suited for this process.

Projects within this research area are funded by the Brigitte-Schlieben-Lange program from the Ministry of Science, Research and Art (MWK) of the state Baden-Württemberg, the German Research Foundation (DFG), intramural funding by the Forschungskommission of the Faculty of Medicine and the Wissenschaftliche Gesellschaft Freiburg. More information http://www.pr.uni-freiburg.de/pm/personalia/wissenschaftliche-karriere-mit-kind

 

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Klinik für Plastische und Handchirurgie

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