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Klinik für Psychiatrie und Psychotherapie

Former Research group Biber

"Adenosine A1-receptors in neuroprotection and mood disorders"

Summary

Adenosine is a neuromodulator in the central nervous system exhibiting anticonvulsive, neuroprotective and sedating/sleep regulating properties. A pathophysiological importance of adenosine in various neuropsychiatric diseases (e.g. epilepsy, neurodegenerative disorders, apoplexia and mood disorders) is envisaged. Our previous work has shown the existence of an interaction between adenosine/adenosine receptors and cytokines in neural cell and tissue cultures in vitro and in experimental animals in vivo. Cytokines are hormone like mediators that regulate both in the immune system and in the central nervous system the function of cells. One of these interactions, the one between the cytokine interleukin-6 (IL-6) und adenosine, elicits a „paradoxical“ upregulation of expression of adenosine A1-receptors under conditions of increased adenosine release reinforcing its neuroprotective, sleep regulating and likely antidepressive actions . This research project investigates the impact of A1-receptor upregulation on behaviour and neuroprotection, which will be assessed by use of a transgenic mouse model that exhibits inducible increased expression of A1-receptors. In addition, we are interested in whether similar actions can also be exhibited by IL-6-like cytokines.

This is a collaborative project with section Psychopharmakotherapy

Key References

  • Moidunny S, Dias RB, Wesseling E, Sekino Y, Boddeke HW, Sebastião AM, Biber K. (2010) Interleukin-6-type cytokines in neuroprotection and neuromodulation: oncostatin M, but not leukemia inhibitory factor, requires neuronal adenosine A1 receptor function. J Neurochem. 114:1667-77.
  • Biber K, Pinto-Duarte A, Wittendorp MC, Dolga AM, Fernandes CC, Von Frijtag Drabbe Künzel J, Keijser JN, de Vries R, Ijzerman AP, Ribeiro JA, Eisel U, Sebastião AM, Boddeke HWGM. (2008) Interleukin-6 upregulates neuronal adenosine A1 receptors: implications for neuromodulation and neuroprotection. Neuropsychopharmacology, Aug;33(9):2237-50.
  • van Calker D, Biber K (2005). The role of glial adenosine receptors in neural resilience and the neurobiology of mood disorders. Neurochem Res. 30:1205-1217.

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